A5002728724- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- GDF15 and Related Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Nutrition and Health in Aging
- Kruppel-like factors research
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Pancreatic function and diabetes
- Calcium signaling and nucleotide metabolism
- Adipose Tissue and Metabolism
- Macrophage Migration Inhibitory Factor
- Genetics and Neurodevelopmental Disorders
- Hepatitis B Virus Studies
- Hedgehog Signaling Pathway Studies
- Muscle Physiology and Disorders
- Sirtuins and Resveratrol in Medicine
- Immune Cell Function and Interaction
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Folate and B Vitamins Research
- Robotic Path Planning Algorithms
GI Innovation (South Korea)
2021-2025
Yonsei University
2017-2023
Songdo Hospital
2020
Severance Hospital
2018
Sungkyunkwan University
2012-2014
Samsung Medical Center
2012-2014
National Academy of Agricultural Science
2013
Samsung (South Korea)
2013
Pusan National University
2007-2013
Fibroblast growth factor 21 (FGF21) plays an important role in the regulation of energy homeostasis during starvation and has excellent therapeutic potential for treatment type 2 diabetes rodents monkeys. Acute exercise affects glucose lipid metabolism by increasing uptake lipolysis. However, it is not known whether acute FGF21 expression. Here, we showed that serum level increased mice after a single bout exercise, this accompanied levels free fatty acid, glycerol ketone body. gene...
Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack approved agents for treating NASH, drugs that can enhance autophagy modulate pathways may be beneficial. Here, we investigated novel mechanism ezetimibe, a widely prescribed drug hypercholesterolemia, as therapeutic option ameliorating NASH. Human liver samples with steatosis NASH were analyzed. For vitro studies inflammasomes,...
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti‐viral activity against influenza virus, adenovirus, coxsackievirus, and human immunodeficiency virus. However, it remains be determined whether curcumin can inhibit replication of hepatitis C virus (HCV). In this study, we showed that decreases HCV gene expression via suppression Akt‐SREBP‐1 activation, not by NF‐κB pathway. The combination IFNα exerted profound inhibitory effects on replication....
Islet amyloid accumulation is a hallmark of human type 2 diabetes (T2D). In contrast to islet polypeptide (hIAPP), murine (mIAPP) does not exhibit amyloidogenic propensity. Because autophagy important in the clearance amyloid-like proteins, we studied transgenic mice with β cell–specific expression hIAPP evaluate contribution T2D-associated hIAPP. hIAPP, deficiency resulted development overt diabetes, which was observed expressing alone or lacking alone. Furthermore, lack hIAPP-expressing...
Autophagy is a critical regulator of cellular homeostasis, dysregulation which associated with diverse diseases. Here we show therapeutic effects novel autophagy enhancer identified by high-throughput screening chemical library against metabolic syndrome. An increases LC3-I to LC3-II conversion without mTOR inhibition. MSL, an enhancer, activates calcineurin, and induces dephosphorylation/nuclear translocation transcription factor EB (TFEB), master lysosomal biogenesis gene expression. MSL...
Growth differentiation factor 15 (GDF15) is an endocrine hormone belonging to the TGFβ superfamily member. GDF15 administration or overexpression has been reported have anti-obesity and anti-diabetic effects. Although non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) frequently associated with obesity insulin resistance, functional role of endogenous therapeutic effect in NASH related metabolic deterioration not evaluated. Here, we found that expression was...
There are diverse links between macroautophagy/autophagy pathways and unfolded protein response (UPR) under endoplasmic reticulum (ER) stress conditions to restore ER homeostasis. Phosphorylation of EIF2S1/eIF2α is an important mechanism that can regulate all three UPR through transcriptional translational reprogramming maintain cellular homeostasis overcome stresses. In this study, investigate the roles EIF2S1 phosphorylation in regulation autophagy during stress, we used phosphorylation-deficient (
HBV (hepatitis B virus) is a primary cause of chronic liver disease, which frequently results in hepatitis, cirrhosis and ultimately HCC (hepatocellular carcinoma). Recently, we showed that HBx (HBV protein X) expression induces lipid accumulation hepatic cells mediated by the induction SREBP1 (sterol-regulatory-element-binding 1), key regulator lipogenic genes liver. However, molecular mechanisms increases transactivation remain to be clearly elucidated. In present study, demonstrated...
Abstract We have reported that autophagy is crucial for clearance of amyloidogenic human IAPP (hIAPP) oligomer, suggesting an enhancer could be a therapeutic modality against diabetes with amyloid accumulation. Here, we show recently identified (MSL-7) reduces hIAPP oligomer accumulation in induced pluripotent stem cell-derived β-cells (hiPSC-β-cells) and diminishes oligomer-mediated apoptosis β-cells. Protective effects MSL-7 β-cell death are significantly reduced cells knockout MiTF/TFE...
Abstract Background Autophagy is elevated in metastatic tumors and often associated with active epithelial‐to‐mesenchymal transition (EMT). However, the extent to which EMT dependent on autophagy largely unknown. This study aimed identify mechanisms by facilitates EMT. Methods We employed a liquid chromatography‐based metabolomic approach kirsten rat sarcoma viral oncogene ( KRAS ) liver kinase B1 LKB1 gene co‐mutated (KL) cells that represent an autophagy/EMT‐coactivated invasive lung...
Background Hepatitis B virus (HBV) is a major cause of chronic liver diseases, and frequently results in hepatitis, cirrhosis, ultimately hepatocellular carcinoma. The role HCV associations with insulin signaling has been elucidated. However, the pathogenesis HBV-associated remains to be clearly characterized. Therefore, we have attempted determine mechanisms underlying impairment signaling. Methodology expressions components were investigated HBx-transgenic mice, HBx-constitutive expressing...
MINT‐7229731: PPAR gamma 2 (uniprotkb:P37231‐2) physically interacts (MI:0914) with NS5A (uniprotkb:P26662) by anti tag coimmunoprecipitation (MI:0007)
Background Adenosine accumulated in the tumor microenvironment functions as an immune-modulating factor, exerting immunosuppressive actions via adenosine A2A/A2B receptor (A2AR/A2BR) various immune cell types. CD73, a key enzymatic regulator responsible for production, is frequently overexpressed diverse cancers, and its overexpression associated with reduced responsiveness to conventional anti-cancer drug treatments such chemotherapy, radiation therapy, targeted or immunotherapy. Despite...