A5002660405- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac tumors and thrombi
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Effects of Exercise
- Hormonal Regulation and Hypertension
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Cardiac Arrest and Resuscitation
Chonnam National University Hospital
2016-2025
Masan University
2025
Chonnam National University
2009-2024
Yonsei University
2014-2022
Loyola University Chicago
2020
Ministry of Health and Welfare
2012-2018
Duke University
2014
Duke Medical Center
2014
Korea Railroad Research Institute
2009
Significance Peroxiredoxin II (PrxII) is the major antioxidant enzyme in red blood cells (RBCs) and occasionally hyperoxidized inactivated during elimination of H 2 O . The abundance Prx was recently shown to oscillate with a period ∼24 h human RBCs, reflecting operation circadian clock. Here we show that oscillation PrxII mouse RBCs driven both by hyperoxidation mediated produced hemoglobin-dependent transport degradation proteasome, rather than reduction sulfiredoxin. About 1% undergoes...
A comprehensive nationwide study on the incidence and outcomes of COVID-19 vaccination-related myocarditis (VRM) is in need.Among 44 276 704 individuals with at least 1 dose vaccination, clinical courses VRM cases confirmed by Expert Adjudication Committee Korea Disease Control Prevention Agency were analyzed. was 480 (1.08 per 100 000 persons). Vaccination-related significantly higher men than women (1.35 vs. 0.82 persons, P < 0.001) mRNA vaccines other (1.46 0.14 0.001). highest males...
Abstract Background Autophagy is elevated in metastatic tumors and often associated with active epithelial‐to‐mesenchymal transition (EMT). However, the extent to which EMT dependent on autophagy largely unknown. This study aimed identify mechanisms by facilitates EMT. Methods We employed a liquid chromatography‐based metabolomic approach kirsten rat sarcoma viral oncogene ( KRAS ) liver kinase B1 LKB1 gene co‐mutated (KL) cells that represent an autophagy/EMT‐coactivated invasive lung...
Abstract Aims While abnormal resting LV GLS has been described in patients with chronic heart failure preserved ejection fraction (HFpEF), its prognostic significance when measured during an acute hospitalization remains unclear. We assessed the association between left ventricular global longitudinal strain (LV GLS) and outcomes hospitalized HFpEF. Methods results studied discharged alive for HFpEF from Duke University Medical Center 2007 2010. Among measurable GLS, we performed 2D,...
Background/Aims A controversy exists about which statin is preferable for patients with acute myocardial infarction (AMI), and clinical impacts of different statins according to lipophilicity have not been established. Methods The 1,124 AMI included in the present study were divided into hydrophilic- lipophilic-statin groups. In-hospital complications (defined as death, cardiogenic shock, ventricular arrhythmia, infection, bleeding, renal insufficiency, other fatal arrhythmias), major...
Elevated red cell distribution width (RDW) has been known to be associated with adverse long-term outcomes in patients cardiovascular diseases. We aimed evaluate relationship between RDW values and clinical paroxysmal atrial fibrillation (AF).We analysed 567 who were newly diagnosed as AF. Clinical after median 4.8 (3.4-6.9) years follow-up. The composite defined the of death, hospitalization due heart failure, new-onset stroke. Bleeding events composed major minor bleeding. was assessed...
Abstract Background We investigated the usefulness of left atrial (LA) strain measurement on prediction upcoming cancer therapeutics-related cardiac dysfunction (CTRCD) after trastuzumab therapy in patients with breast who did not develop CTRCD chemotherapy. Methods A total 72 females chemotherapy and underwent additional were divided into ( n = 13) no group 59). Echocardiographic measurements including ventricular global longitudinal (LVGLS) peak (PALS) decline compared. Results was...
Serial intravascular ultrasound (IVUS) was used to compare the effects of moderate doses rosuvastatin and atorvastatin on plaque regression in patients with intermediate coronary stenosis.This a prospective, randomized, comparative study for lipid-lowering therapy 20mg (n=65) 40mg (n=63) using serial IVUS (baseline 11-month follow-up). Efficacy parameters included changes total atheroma volume (TAV) percent (PAV) from baseline follow-up. Changes TAV (-4.4±7.3 vs. -3.6±6.8mm(3), P=0.5) PAV...
Abstract Early identification of women at high risk for cardiovascular diseases (CVD), with subsequent monitoring, will allow improved clinical outcomes and generally better quality life. This study aimed to identify the associations between early menopause, abnormal diastolic function, outcomes. retrospective included 795 menopausal from is a nationwide, multicenter, registry patients suspected angina visiting outpatient clinic. The into two groups: normal menopause (menopausal age ≤ 45...
Background: Myocardial bridge (MB) is regarded as a common benign lesion on coronary angiography (CAG). It known to be harmless but may cause several cardiac events and recurrent hospitalization, so in the present study long-term clinical course of patients with isolated MB predictors readmission were investigated. Methods Results: Total 684 (343 males, 60.5±11.2 years) persistent chest pain without critical stenosis CAG enrolled. The divided into 2 groups according presence MB. Clinical...
Background The aim of this study was to assess the age-related differences in intravascular ultrasound (IVUS) findings target lesions patients with coronary artery disease. Methods and Results 1,009 who underwent IVUS imaging were grouped according an increase 10 years age: Group I [<50 (n=144)]; II [51-60 (n=259)]; III [61-70 (n=249)]; IV [71-80 (n=264)]; V [>80 years, (n=93)]. Calcified plaque (18%, 25%, 33%, 38%, 46%, p<0.001) negative remodeling (29%, 48%, 44%, 66%, most common,...
We aimed to compare the efficacy and safety between non-vitamin K antagonist oral anticoagulants (NOACs) warfarin in atrial fibrillation (AF) patients according renal dysfunction.We analysed 1319 who had been taken anticoagulants. They were classified into taking NOACs (n = 326) 993). Renal dysfunction was defined as estimated glomerular filtration rate <60 mL/min by using Chronic Kidney Disease Epidemiology Collaboration equation. The composite clinical outcomes of death, hospitalization,...
To investigate the impacts of carotid plaque and intima-media thickness (IMT) on future vascular events (VEs) in patients with acute ischemic stroke. A total 479 consecutive Korean stroke were divided into 2 groups according to development VEs; VE group (65.4 ± 10.9 years) vs no (62.8 13.2 years). VEs defined as recurrent stroke, coronary events, peripheral arterial disease, death. Clinical, laboratory, imaging findings compared between groups. During 105.5 29.0 months follow up, developed...
Background/Aims The aim of this study was to investigate useful cardiac biomarkers in the differential diagnosis acute pulmonary embolism (APE) with troponin elevation from non-ST myocardial infarction (NSTEMI). Methods A total 771 consecutive NSTEMI patients D-dimer measurements and 90 troponin-I (TnI) out 233 APE were enrolled, compared. Results noted 382 (49.5%), TnI (38.6%). Unnecessary coronary angiography performed 10 (11.1%) among elevation. significantly elevated than (9.9 ± 11.6...