A5044698836- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Cardiovascular Function and Risk Factors
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Diabetes Management and Education
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Body Composition Measurement Techniques
- Mobile Health and mHealth Applications
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Nanoparticles: synthesis and applications
- Chronic Kidney Disease and Diabetes
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Integrated Circuits and Semiconductor Failure Analysis
Samsung Medical Center
2017-2025
Sungkyunkwan University
2017-2025
Korea Advanced Institute of Science and Technology
2022-2025
Korea Basic Science Institute
2023-2025
Yonsei University
2015-2025
Dong-A University
2021-2025
Gyeongsang National University
2022-2025
Institute for Basic Science
2025
Myongji University
2024
Korea University
2024
Abstract Kidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to contribute diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent apoptosis and caspase-1-dependent pyroptosis are also involved in under conditions. Recently, ferroptosis, an atypical form iron-dependent death, was reported cause kidney disease, including acute injury. Ferroptosis primed lipid peroxide accumulation through the cystine/glutamate antiporter system X c − (xCT)...
Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack approved agents for treating NASH, drugs that can enhance autophagy modulate pathways may be beneficial. Here, we investigated novel mechanism ezetimibe, a widely prescribed drug hypercholesterolemia, as therapeutic option ameliorating NASH. Human liver samples with steatosis NASH were analyzed. For vitro studies inflammasomes,...
Nonalcoholic fatty liver disease (NAFLD) has been associated with relative skeletal muscle mass in several cross-sectional studies. We explored the effects of and changes over time on development incident NAFLD or resolution baseline a large, longitudinal, population-based 7-year cohort study. included 12,624 subjects without 2943 who underwent health check-up examinations. A total 10,534 2631 were analysis year. Subjects defined as having by hepatic steatosis index, previously validated...
Both type 1 and 2 diabetes are well-established risk factors for cardiovascular disease early mortality. However, few studies have directly compared the hazards of outcomes premature death among people with to those subjects without diabetes. Furthermore, information about hazard mortality Asians is sparse, although clinical epidemiological characteristics unlike Europeans. We estimated myocardial infarction (MI), hospitalization heart failure (HF), atrial fibrillation (AF), during follow-up...
Acid–base imbalance has been reported to increase incidence of hypertension and diabetes. However, the association between diet-induced acid load cardiovascular disease (CVD) risk in general population not fully investigated. This was a population-based, retrospectively registered cross-sectional study using nationally representative samples 11,601 subjects from Korea National Health Nutrition Examination Survey 2008–2011. Individual CVD evaluated atherosclerotic (ASCVD) equations according...
Background: As the use of continuous glucose monitoring (CGM) has increased, time in range (TIR) and other core CGM metrics are now emerging as for clinical targets assessing diabetic complications, beyond HbA1c. This study investigated association between CGM-derived TIR, hyperglycemia, hypoglycemia metrics, albuminuria. Methods: A total 866 subjects with type 2 diabetes who underwent 3 or 6 days had urinary albumin-to-creatinine ratio (ACR) measurements were retrospectively reviewed....
The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney fibrosis. However, it unknown whether PGC-1α, a key biogenesis regulator, modulates in injury. Primary renal tubular epithelial cells (RTECs) were isolated from C57BL/6 mice. inflammasome, dynamics morphology, oxidative stress, cell injury markers examined RTECs treated TGF-β1 with or without Ppargc1a plasmid, PGC-1α activator (metformin), siPGC-1α. In vivo, adenine-fed unilateral ureteral obstruction (UUO)...
Although both type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are associated with increased risk of cardiovascular (CVD), evidence is lacking as to whether the presence NAFLD confers an additional CVD in patients T2DM. We investigated associations between hepatic steatosis and/or fibrosis myocardial infarction (MI), stroke, heart failure (HF), mortality new-onset T2DM.Using Korean National Health Insurance dataset, we included 139,633 diagnosed T2DM who underwent...
Childhood neglect and/or abuse can induce mental health conditions with unknown mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated synapse phagocytosis. Using in vitro, vivo, and human brain organoid experiments, showed that increased the expression Mertk phagocytic receptor astrocytes through glucocorticoid (GR). In post-natal mice, exposure to early social deprivation (ESD) specifically activated GR-MERTK pathway astrocytes, but not microglia. The...
OBJECTIVE We investigated the efficacy of an integrated digital health care platform with artificial intelligence (AI)–based dietary management in adults type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In this 48-week, open-label, randomized, multicenter clinical trial, overweight or obese T2D were randomly assigned to one three groups a 1:1:1 ratio: group A received routine care; B used by themselves; and C feedback from medical staff intermittently applied personal continuous glucose...
Abstract Here we report SUPPORT (statistically unbiased prediction utilizing spatiotemporal information in imaging data), a self-supervised learning method for removing Poisson–Gaussian noise voltage data. is based on the insight that pixel value data highly dependent its neighboring pixels, even when temporally adjacent frames alone do not provide useful statistical prediction. Such dependency captured and used by convolutional neural network with blind spot to accurately denoise which...
Abstract Polymer binders are essential for Silicon (Si) anode‐based lithium‐ion batteries (LIBs). However, the synthetic guidance aromatic polymer binder is relatively less explored compared to aliphatic binders. In this study, polyimide‐based developed that have strong binding affinity with Si particles, a conductive agent and copper (Cu) current collector, they show an improved initial discharge capacity of 2663 mAh g −1 , which 29% higher than Kapton‐based one (2071 ). The...
We aimed to investigate the predictive values of plasma C-peptide levels and continuous glucose monitoring (CGM)-defined coefficient variation (CV) in risk prediction for hypoglycemia Korean people with diabetes normal impaired kidney function. analyzed data from 1,185 participants diagnosed type 1 2 who underwent blinded professional CGM between January 2009 May 2021 at outpatient clinics. explored correlations among CGM-defined CV, levels, time below range <70 54 mg/dL across different...
Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. The aim of this study to investigate the impact baseline skeletal and changes over time on development a large population-based 7-year cohort study. A total 14,830 11,639 individuals who underwent health examinations at Health Promotion Center Samsung Medical Center, Seoul, Korea were included analyses those from 1 year, respectively. estimated by bioelectrical impedance...
Relationship on new statin use and the risk of hepatocellular carcinoma (HCC) in patients with incident type 2 diabetes mellitus (T2DM), who might be at developing HCC, is uncertained. A nationwide population–based nested case–control study was conducted within National Health Insurance Service Sample Cohort 2002–2013 Korea. Newly prescribed after newly diagnosed T2DM defined as use. Controls were matched to case age, sex, follow–up time, date diagnosis a five–to–one ratio. Odds ratios (ORs)...
Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic and independently affects the development cardiovascular (CV) disease. We investigated whether steatosis and/or fibrosis are associated with incident heart failure (iHF), hospitalized HF (hHF), mortality, CV death in both general population patients.We analyzed 778,739 individuals without 7445 patients pre-existing aged 40 to 80 years who underwent national health check-up from January 2009 December 2012. The...
We investigated the effects of a physical activity encouragement intervention based on smartphone personal health record (PHR) application (app) step count increases, glycemic control, and body weight in patients with type 2 diabetes (T2D).