A5047082140- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Identification and Quantification in Food
- Acupuncture Treatment Research Studies
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Aquaculture disease management and microbiota
- Porphyrin Metabolism and Disorders
- Plant Reproductive Biology
- Enzyme Structure and Function
- CRISPR and Genetic Engineering
- Protein Structure and Dynamics
- Plant and animal studies
- Plant Disease Resistance and Genetics
- Liquid Crystal Research Advancements
- Dialysis and Renal Disease Management
- Oral microbiology and periodontitis research
- Chemical Synthesis and Analysis
- Enzyme Production and Characterization
- Forest ecology and management
- Advanced biosensing and bioanalysis techniques
- Plant Pathogenic Bacteria Studies
- Cancer Genomics and Diagnostics
- Biosensors and Analytical Detection
University of California, Santa Cruz
2023-2025
Dongguk University
2023-2025
University of Ulsan
2017-2025
Asan Medical Center
2022-2025
Ulsan College
2022-2025
Yonsei University
2015-2024
Seoul National University
2010-2024
Pusan National University
2014-2024
Korea Forest Service
2023-2024
Oakland University
2024
Significance In the past decade, countless studies have been performed to control mechanical and corrosion property of magnesium-based alloy, which degrades in physiological environment, overcome flaws inert implant materials shift paradigm conventional bone fixation devices. Controlled degradation Mg-5wt%Ca-1wt%Zn alloy results formation biomimicking calcification matrix at degrading interface initiate process. This process facilitates early healing allows complete replacement biodegradable...
Abstract The development of efficient and stable water oxidation catalysts is necessary for the realization practically viable water-splitting systems. Although extensive studies have focused on metal-oxide catalysts, effect metal coordination catalytic ability remains still elusive. Here we select four cobalt-based phosphate with various cobalt- phosphate-group as a platform to better understand activity materials. they exhibit activities stabilities during oxidation, Na 2 CoP O 7 distorted...
The development of a water oxidation catalyst has been demanding challenge in realizing splitting systems. asymmetric geometry and flexible ligation the biological Mn4CaO5 cluster are important properties for function photosystem II, these can be applied to design new inorganic catalysts. We identified crystal structure, Mn3(PO4)2·3H2O, that precipitates spontaneously aqueous solution at room temperature demonstrated its high catalytic performance under neutral conditions. bulky phosphate...
Abstract Kidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to contribute diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent apoptosis and caspase-1-dependent pyroptosis are also involved in under conditions. Recently, ferroptosis, an atypical form iron-dependent death, was reported cause kidney disease, including acute injury. Ferroptosis primed lipid peroxide accumulation through the cystine/glutamate antiporter system X c − (xCT)...
The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney fibrosis. However, it unknown whether PGC-1α, a key biogenesis regulator, modulates in injury. Primary renal tubular epithelial cells (RTECs) were isolated from C57BL/6 mice. inflammasome, dynamics morphology, oxidative stress, cell injury markers examined RTECs treated TGF-β1 with or without Ppargc1a plasmid, PGC-1α activator (metformin), siPGC-1α. In vivo, adenine-fed unilateral ureteral obstruction (UUO)...
The combination of ultra-long (UL) Oxford Nanopore Technologies (ONT) sequencing reads with long, accurate Pacific Bioscience (PacBio) High Fidelity (HiFi) has enabled the completion a human genome and spurred similar efforts to complete genomes many other species. However, this approach for complete, “telomere-to-telomere” assembly relies on multiple platforms, limiting its accessibility. ONT “Duplex” reads, where both strands DNA are read improve quality, promise high per-base accuracy. To...
Reference-free genome phasing is vital for understanding allele inheritance and the impact of single-molecule DNA variation on phenotypes. To achieve thorough across homozygous or repetitive regions genome, long-read sequencing technologies are often used to perform phased de novo assembly. As a step toward reducing cost complexity this type analysis, we describe new methods accurately Oxford Nanopore Technologies (ONT) sequence data with Shasta assembler modular tool extending chromosome...
Cell-free expression systems enable rapid prototyping of genetic programs in vitro. However, current throughput cell-free measurements is limited by the use channel-limited fluorescent readouts. Here, we describe DNA Regulatory element Analysis cell-Free Transcription and Sequencing (DRAFTS), a robust vitro approach for multiplexed measurement transcriptional activities from thousands regulatory sequences single reaction. We employ this method active cell lysates developed ten diverse...
Abstract Most current studies rely on short-read sequencing to detect somatic structural variation (SV) in cancer genomes. Long-read offers the advantage of better mappability and long-range phasing, which results substantial improvements germline SV detection. However, long-read detection methods do not generalize well analysis SVs tumor genomes with complex rearrangements, heterogeneity, aneuploidy. Here, we present Severus: a method for accurate different types using phased breakpoint...
The combination of ultra-long Oxford Nanopore (ONT) sequencing reads with long, accurate PacBio HiFi has enabled the completion a human genome and spurred similar efforts to complete genomes many other species. However, this approach for complete, "telomere-to-telomere" assembly relies on multiple platforms, limiting its accessibility. ONT "Duplex" reads, where both strands DNA are read improve quality, promise high per-base accuracy. To evaluate new data type, we generated Duplex three...
Objective To investigate cyclooxygenase-2 (COX-2) mRNA expression in curatively resected non-small cell lung cancer (NSCLC) and to determine its association with prognosis. Summary Background Data Lung is one of the most common malignancies world. Despite improvements diagnosis treatment NSCLC, 5-year survival rate remains less than 15%. Identification prognostic predictors based on molecular alterations could lead additional diagnostic tools eventually more effective therapeutic options....
Label-free bacterial sensors using specific interplay between released-surfactin and polydiacetylene (PDA) liposomes.
This study presents a separable and recombinable magnetic robot (SRMR) to deliver retrieve an untethered (UMR) target vascular lesion safely effectively for robotic endovascular intervention. The SRMR comprises delivery catheter UMR connected the end of by connecting section. An external field (EMF) interacts with permanent magnet UMR; it can generate torque steer reach lesion. Furthermore, rotating EMF allows separate from perform tunneling task. After completing task, be recombined in...
A Gram-stain-negative, non-flagellated, non-gliding, aerobic and rod-shaped or ovoid bacterial strain, designated W-BA7 T , was isolated from a brown alga reservoir on the South Sea in Korea. This strain grew optimally at 25 °C, pH 7.0–8.0 presence of approximately 2.0 % (w/v) NaCl. neighbour-joining phylogenetic tree based 16S rRNA gene sequences showed that belonged to genus Polaribacter clustering coherently with type sejongensis showing 99.3 sequence similarity. Strain exhibited...
Developing an artificial extracellular matrix that closely mimics the native tissue microenvironment is important for use as both a cell culture platform controlling fate and in vitro model system investigating role of cellular microenvironment. Electrospinning, one methods fabricating structures mimic ECM, promising technique creating fibrous platforms. It well-known align or randomly distributed electrospun fibers provide contact guidance single pattern. However, tissues have hierarchical...
Abstract Protein serine/threonine/tyrosine (S/T/Y) phosphorylation is an essential and frequent post-translational modification in eukaryotes, but historically has been considered less prevalent bacteria because fewer proteins were found to be phosphorylated most modified a lower degree. Recent proteomics studies greatly expanded the phosphoproteome of Escherichia coli more than 2000 sites (phosphosites), yet mechanisms action proposed for only six phosphosites fitness effects described 38...