A5078723510- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Phagocytosis and Immune Regulation
- Lysosomal Storage Disorders Research
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Cellular transport and secretion
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Barrier Structure and Function Studies
- Erythrocyte Function and Pathophysiology
- Carbohydrate Chemistry and Synthesis
Korea Advanced Institute of Science and Technology
2018-2025
Stanford University
2024-2025
Institute for Basic Science
2025
Childhood neglect and/or abuse can induce mental health conditions with unknown mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated synapse phagocytosis. Using in vitro, vivo, and human brain organoid experiments, showed that increased the expression Mertk phagocytic receptor astrocytes through glucocorticoid (GR). In post-natal mice, exposure to early social deprivation (ESD) specifically activated GR-MERTK pathway astrocytes, but not microglia. The...
Fabry disease (FD), a lysosomal storage disorder, is caused by defective α-galactosidase (GLA) activity, which results in the accumulation of globotriaosylceramide (Gb3) endothelial cells and leads to life-threatening complications such as left ventricular hypertrophy (LVH), renal failure, stroke. Enzyme replacement therapy (ERT) Gb3 clearance; however, because short half-life body high immunogenicity FD patients, ERT has limited therapeutic effect, particularly patients with late-onset or...
Astrocytes are the major cell type in brain and directly contact synapses blood vessels. Although microglial cells have been considered immune only phagocytes brain, recent studies shown that astrocytes also participate various phagocytic processes, such as developmental synapse elimination clearance of amyloid beta plaques Alzheimer's disease (AD). Despite these findings, efficiency astrocyte engulfment degradation their targets is unclear compared with microglia. This lack information...
Astrocytes are the major cell type in brain and directly contact synapses blood vessels. Although microglial cells have been considered immune only phagocytes brain, recent studies shown that astrocytes also participate various phagocytic processes, such as developmental synapse elimination clearance of amyloid beta plaques Alzheimer's disease (AD). Despite these findings, efficiency astrocyte engulfment degradation their targets is unclear compared with microglia. This lack information...
Neurogenetic disorders, such as neurofibromatosis type 1 (NF1), can cause cognitive and motor impairments, traditionally attributed to intrinsic neuronal defects disruption of synaptic function. Activity-regulated oligodendroglial plasticity also contributes functions by tuning neural circuit dynamics. However, the relevance neurological dysfunction in NF1 is unclear. Here we explore contribution oligodendrocyte progenitor cells (OPCs) pathological features syndrome mice. Both male female...
Abstract Oligodendrocyte precursor cells (OPCs) are progenitor that give rise to central nervous system oligodendrocytes throughout life. Transcriptomic and lineage tracing studies suggest OPCs may be the putative cell of origin for many glioma histologic subtypes. While children with neurofibromatosis type 1 (NF1) cancer predisposition syndrome prone low-grade gliomas following bi-allelic NF1 loss, cellular molecular etiologies underlying tumorigenesis remain incompletely elucidated. Using...