A5007217873- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Photoreceptor and optogenetics research
Stanford University
2021-2025
Palo Alto University
2021
Abstract Pediatric high-grade gliomas are the leading cause of brain cancer-related death in children. High-grade include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline (DMG) such as intrinsic pontine glioma (DIPG) hemispheric gliomas. Neuronal activity drives progression both through paracrine signaling 1,2 direct neuron-to-glioma synapses 3–5 . Glutamatergic, AMPA receptor-dependent between neurons malignant cells have been...
Abstract High-grade gliomas include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline (DMG) such as intrinsic pontine glioma (DIPG) hemispheric high-grade gliomas. Neuronal activity drives progression both through paracrine signaling direct neuron-to-glioma synapses. Glutamatergic, AMPA receptor-dependent synapses between neurons malignant cells have been demonstrated in pediatric adult gliomas, but mediated other neurotransmitters remain...
Abstract Pediatric high-grade gliomas, including diffuse intrinsic pontine glioma (DIPG), are the leading cause of brain cancer-related death in children. While enormous progress has been made recent years for many forms cancer, gliomas remain seemingly intractable, indicating that fundamental aspects growth not yet sufficiently understood. Neuronal activity drives both through paracrine signaling and direct neuron-to-glioma synapses. Recently glutamatergic, AMPA receptor-dependent synapses...