A5007204226- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Diabetes and associated disorders
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Alcohol Consumption and Health Effects
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Peroxisome Proliferator-Activated Receptors
- Lipoproteins and Cardiovascular Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Advanced Glycation End Products research
- Autophagy in Disease and Therapy
- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
- Pharmacology and Obesity Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Liver Disease and Transplantation
Yonsei University
2016-2025
Yonsei University Health System
2015-2025
Hallym University Kangnam Sacred Heart Hospital
2025
Severance Hospital
2014-2024
University Medical Center Utrecht
2024
Seoul St. Mary's Hospital
2023
Catholic University of Korea
2023
Daegu University
2018
Dà-Jiāng Innovations Science and Technology (China)
2015
Hallym University
2006-2013
The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access the databases within Korean Diabetes Association for benefit of subjects with diabetes. Here, we present history, structure, contents, and way use data procurement in (NHI) system researchers.The NHIS Korea is a single-payer program mandatory all residents Korea. three main healthcare programs NHI, Medical Aid, long-term care insurance (LTCI) 100% coverage population. has adopted...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type diabetes (T2D); however, the underlying mechanism remains unclear. Activation of NLR family, pyrin domain-containing 3 (NLRP3) inflammasome and subsequent interleukin (IL)-1β release induces atherosclerosis heart failure. Here we show effect SGLT2 inhibitor empagliflozin on NLRP3 activity. Patients T2D high risk receive or sulfonylurea for 30 days, activation analyzed macrophages. While...
Sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD). This study investigated whether sarcopenia significant fibrosis in subjects NAFLD. Data from the Korean National Health and Nutrition Examination Surveys 2008‐2011 database were analyzed. NALFD was defined by NAFLD fat score, comprehensive or hepatic steatosis index. Degree of assessed score (NFS), FIB‐4, Forns Significant as FIB‐4 ≥2.67 highest quartile values NFS index (= total appendicular skeletal muscle mass...
Metformin activates both PRKA and SIRT1. Furthermore, autophagy is induced by either the PRKA-MTOR-ULK1 or SIRT1-FOXO signaling pathways. We aimed to elucidate mechanism which metformin alleviates hepatosteatosis examining molecular interplay between SIRT1, PRKA, autophagy. ob/ob mice were divided into 3 groups: one with ad libitum feeding of a standard chow diet, 300 mg/kg intraperitoneal injections, g/d caloric restriction (CR) for period 4 wk. Primary hepatocytes HepG2 cells treated oleic...
Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack approved agents for treating NASH, drugs that can enhance autophagy modulate pathways may be beneficial. Here, we investigated novel mechanism ezetimibe, a widely prescribed drug hypercholesterolemia, as therapeutic option ameliorating NASH. Human liver samples with steatosis NASH were analyzed. For vitro studies inflammasomes,...
Despite the mechanistic potential of sodium-glucose cotransporter 2 inhibitor (SGLT2i) to improve neurologic outcomes, efficacy SGLT2i in neurodegenerative disorders among patients with type diabetes is not well established. This population-based cohort study aimed investigate association use risks incident dementia and Parkinson disease (PD) diabetes.
Background Non-alcoholic fatty liver disease (NAFLD) is a prevalent and rapidly increasing worldwide; however, no widely accepted screening models to assess the risk of NAFLD are available. Therefore, we aimed develop validate self-assessment score for in general population using two independent cohorts. Methods The development cohort comprised 15676 subjects (8313 males 7363 females) who visited National Health Insurance Service Ilsan Hospital Korea 2008–2010. Anthropometric, clinical,...
Betatrophin/angiopoietin-like protein 8 (ANGPTL8) is a liver-secreted recently identified as potent stimulator of beta cell proliferation in mice. However, it unclear how betatrophin regulated humans with non-alcoholic fatty liver disease (NAFLD). We investigated the role mice and without NAFLD. Serum levels were examined by ELISA 164 subjects, including 96 patients Levels significantly elevated subjects NAFLD compared controls (1.301 ± 0.617 vs. 0.900 0.574 μg/L, P < 0.001), even after...
Acid–base imbalance has been reported to increase incidence of hypertension and diabetes. However, the association between diet-induced acid load cardiovascular disease (CVD) risk in general population not fully investigated. This was a population-based, retrospectively registered cross-sectional study using nationally representative samples 11,601 subjects from Korea National Health Nutrition Examination Survey 2008–2011. Individual CVD evaluated atherosclerotic (ASCVD) equations according...
Big data reports related to diseases and health care for the Korean population have been published since National Health Insurance Service (NHIS) Review & Assessment (HIRA) provided limited open access their databases. Here, we reviewed structure, content, means of using from (NHI) system benefit researchers presented latest publication trends in healthcare procured NHI HIRA
Despite the rapidly increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2D), few treatment modalities are currently available.We investigated hepatic effects novel thiazolidinedione (TZDs), lobeglitazone (Duvie) T2D patients with NAFLD.We recruited drug-naïve or metformin-treated NAFLD to conduct a multicenter, prospective, open-label, exploratory clinical trial.Transient elastography (Fibroscan®; Echosens, Paris, France) controlled attenuation parameter...
Nonalcoholic fatty liver disease (NAFLD) and sarcopenia have a close association with an increased risk of atherosclerotic cardiovascular (ASCVD). This study investigated the influence NAFLD on ASCVD risk.Data from 2008-2011 Korean National Health Nutrition Examination Surveys database were analyzed (n = 7,191). The index was calculated using dual-energy x-ray absorptiometry. Sarcopenia defined as lowest quintile value (cutoffs 0.882 for men 0.582 women). comprehensive score ≥40. Liver...
Amyloid-β (Aβ) accumulation in the brain is a pathological feature of Alzheimer's disease (AD) and enhancing Aβ clearance potential therapeutic strategy. Pioglitazone peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist widely used to treat type 2 diabetes. We previously reported that low-dose pioglitazone increased expression low-density lipoprotein receptor-related protein 1 (LRP1), which upregulates Aβ, using human microvascular endothelial cells. investigated whether can rescue...
: Nonalcoholic fatty liver disease (NAFLD) and obesity are independently associated with an increased risk for atherosclerotic cardiovascular (ASCVD), the leading cause of mortality in patients NAFLD. Many NAFLD lean, but their ASCVD compared to obese subjects is unclear.Data from 2008 2011 Korea National Health Nutrition Examination Surveys database were analyzed (n=4,786). was defined as a comprehensive score ≥40 or fat ≥-0.640. evaluated using American College Cardiology/ Heart...
Abstract Background The effect of ezetimibe, Niemann-Pick C1-like 1 inhibitor, on liver fat is not clearly elucidated. Our primary objective was to evaluate the efficacy ezetimibe plus rosuvastatin versus monotherapy reduce using magnetic resonance imaging-derived proton density fraction (MRI-PDFF) in patients with non-alcoholic fatty disease (NAFLD). Methods A randomized controlled, open-label trial 70 participants NAFLD confirmed by ultrasound who were assigned receive either 10 mg 5 daily...
In patients with chronic kidney disease (CKD) and type 2 diabetes (T2D), finerenone, a nonsteroidal mineralocorticoid receptor antagonist, reduces cardiovascular failure outcomes. Finerenone also lowers the urine albumin-to-creatinine ratio (UACR). Whether finerenone-induced change in UACR mediates outcomes is unknown.
The conventional glycemic indices used in management of diabetic patients includes A1c, fructosamine, 1,5-anhydroglucitol, and glycated albumin (GA). Among these indices, A1c is currently as the gold standard. However, cannot reflect change over a relatively short period time, its accuracy known to decrease when abnormalities hemoglobin metabolism, such anemia, coexist. When considering weaknesses, there have been needs for finding novel index diagnosing managing diabetes, well predicting...