A5100443303- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Ophthalmology and Eye Disorders
- Thyroid Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Thyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Glaucoma and retinal disorders
- Estrogen and related hormone effects
- Metabolism, Diabetes, and Cancer
- Cardiovascular Health and Disease Prevention
- Neuroendocrine Tumor Research Advances
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Virus-based gene therapy research
- Bone health and osteoporosis research
- Adipose Tissue and Metabolism
- Adrenal Hormones and Disorders
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Diet and metabolism studies
Yonsei University
2016-2025
Korea University
2025
Severance Hospital
2015-2024
Kangwon National University
2024
University Medical Center Utrecht
2024
Daegu Fatima Hospital
2023
Samsung Medical Center
2019
Asan Medical Center
2019
University of Ulsan
2019
Seoul National University Hospital
2019
The pituitary gonadotropins luteinizing hormone and follicle-stimulating (FSH) regulate the production of sex steroids necessary for pubertal development fertility. Inherited genetic defects that cause hypogonadism have been identified at multiple levels hypothalamic–pituitary–gonadal axis.1 They include Kallmann's syndrome, which is caused by mutations in KAL gene,2 X-linked adrenal hypoplasia, DAX-1 gene.3 Both deficiency hypothalamic gonadotropin-releasing hormone, also a defect...
The involvement of estrogen receptor beta (ERβ) in prostate carcinogenesis has been hypothesized. Several reports have shown that ERβ expression was decreased when cells undergo neoplastic transformation, suggesting it could play a tumor‐suppressor role. By restoring prostatic carcinoma by adenoviral delivery, we aimed to test this hypothesis. We observed strongly inhibited the invasiveness and growth these cells. In addition, were undergoing apoptosis, as quantification Bax,...
Several studies report that detection of thyroglobulin (Tg) in fine-needle aspiration (FNA) biopsy washout fluid from lymph nodes identifies recurrences/metastases differentiated papillary thyroid cancer (DPTC) the neck with higher sensitivity and specificity than cytology (FNAC). However, diagnostic FNA-Tg cutoff values have not yet been established.To determine an appropriate threshold value for Tg levels FNA patients node metastases or recurrences DPTC.We performed ultrasound (US)-guided...
To determine whether circulating metabolic intermediates are associated with inflammation, oxidative stress and arterial stiffness in men newly diagnosed type 2 diabetes investigate the that may predict risk of developing diabetes.Men (n = 26) age- body mass index-matched nondiabetic 27) were included. We measured inflammatory markers by brachial-ankle pulse wave velocity (ba-PWV). Metabolomic profiling was analysed ultra performance liquid chromatography quadrupole time-of-flight...
Purpose:The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial.We aimed to evaluate the relationship serum 25-hydroxy-vitamin D3 [25(OH)D3] anti-thyroid antibody levels.Materials Methods: 25(OH)D3, antibodies, function measured in 304 patients who visited endocrinology clinic were analyzed.The subgrouped into AITDs or non-AITDs category according presence absence of antibodies.The peroxidase (TPOAb) 25(OH)D3 was evaluated.Results: The with...
Despite the mechanistic potential of sodium-glucose cotransporter 2 inhibitor (SGLT2i) to improve neurologic outcomes, efficacy SGLT2i in neurodegenerative disorders among patients with type diabetes is not well established. This population-based cohort study aimed investigate association use risks incident dementia and Parkinson disease (PD) diabetes.
BACKGROUND: Although cell therapy has emerged as a promising approach to promote neovascularization, its effects are mostly limited capillaries. To generate larger or stable vessels, layering of mural cells such smooth muscle (SMCs) pericytes is required. Recently, direct reprogramming approaches have been developed for generating SMCs. However, reprogrammed SMCs lack genuine features contractile SMCs, native SMC phenotype; thus, their therapeutic and vessel-forming potential in vivo was not...
We created a nonclassical estrogen receptor (ER) knock-in mouse model by introducing mutation that selectively eliminates classical ER signaling through response elements, while preserving the pathway. Heterozygous (NERKI) females are infertile. Their ovaries contain no corpora lutea, reflecting defect in ovulation, and stromal cells lipid droplets, suggesting altered steroidogenesis. The uteri enlarged with evidence of cystic endometrial hyperplasia, mammary glands hypoplastic. These...
Ovarian follicles undergo exponential growth in response to follicle-stimulating hormone (FSH), largely as a result of the proliferation granulosa cells (GCs). In vitro under serum-free conditions, rat GCs differentiate FSH but do not proliferate unless activin is also present. presence plus activin, exhibit enhanced expression cyclin D2 well inhibin-α, aromatase, steroidogenic factor-1 (SF-1), cholesterol side chain (SCC), and epiregulin. this report we sought identify signaling pathways by...
Pendred's syndrome is an autosomal recessive disorder characterized by sensorineural deafness, goiter, and impaired iodide organification. It caused mutations in the PDS/SLC26A4 gene that encodes pendrin. Functionally, pendrin a transporter of chloride Xenopus oocytes heterologous mammalian cells chloride/base exchanger β-intercalated renal cortical collecting duct. The partially thyroidal organification suggests possible role transport at apical membrane thyroid follicular cells, but...
Abstract In bone marrow, osteoblasts and adipocytes are differentiated from mesenchymal progenitor cells their differentiation is reciprocally regulated by largely unknown mechanisms. this study, we investigated downstream signaling cascades of adiponectin, a member the adipocytokine family, in regulation osteoblast differentiation. Adiponectin augmented expression several osteogenic marker genes increased cells. The cyclooxygenase-2 (COX2) was potently whereas inhibition COX2 activity...
Acting via the estrogen receptor (ER), estradiol exerts pleomorphic effects on uterus, producing cyclical waves of cellular proliferation and differentiation in preparation for embryo implantation. In classical pathway, ER binds directly to an response element activate or repress gene expression. However, emerging evidence supports existence nonclassical pathways which activated alters expression through protein-protein tethering with transcription factors such as c-Fos/c-Jun B (AP-1) Sp1....
Abstract The transforming growth factor-β (TGF-β) superfamily of factors is responsible for a variety physiologic actions, including cell cycle regulation. Activin member the TGF-β that inhibits proliferation breast cancer cells. functions by interacting with its type I and II receptors to induce phosphorylation intracellular signaling molecules known as Smads. Smads regulate transcription many genes in cell- tissue-specific manner. In this study, role activin A regulation cells was...
FSH stimulation of granulosa cells (GCs) results in increased hypoxia-inducible factor (HIF)-1alpha protein levels and HIF-1 activity that is necessary for up-regulation certain target genes including vascular endothelial growth factor. We report the role phosphatidylinositol (PI)-3-kinase/AKT pathway increasing HIF-1alpha FSH-stimulated GCs extends beyond an increase mammalian rapamycin-stimulated translation. increases phosphorylation AKT mouse double-minute 2 (MDM2); a phosphomimetic...
Nonfunctioning pituitary adenomas are commonly diagnosed as large tumors. Most detected incidentally during imaging studies or a result of neurological manifestations. Depending on severity, most patients with tumors require surgery and adjunctive therapies because the high rate tumor recurrence. The ability to predict recurrence at time initial would be helpful in deciding whether therapy is necessary decreasing morbidity. We investigated use several cellular markers for predicting...
Olfactory receptor (OR)-associated events are mediated by well-conserved components in the olfactory epithelium, including G-protein (Golf), adenylate cyclase III (ACIII), and marker protein (OMP). The expression of ORs has recently been observed non-olfactory tissues where they involved monitoring extracellular chemical cues. large number OR genes their sequence similarities illustrate need to find an effective simple way detect OR-associated events. In addition, profiles physiological...
Abstract Context Reports on the incidence, characteristics, and comorbidity in Asian patients with acromegaly are scarce. Objective To evaluate incidence of risk comorbidities East Asia, especially South Korea. Design This nationwide population-based cohort study using Korean Health Insurance Review Assessment claims database evaluated acromegaly, initially diagnosed from 2010 to 2013. We identified during, before, 2 years after diagnosis. Acromegaly control cases (718 7180, respectively)...
Layman, Lawrence C.; Lee, Eun-Jig; Peak, Douglas B.; Namnoum, Anne Vu, Kenneth V.; van Lingen, Barbara L.; Gray, Mark R.; McDonough, Paul G.; Reindollar, Richard H.; Jameson, Larry J. Author Information