A5100385017- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Biochemical Analysis and Sensing Techniques
- melanin and skin pigmentation
- Respiratory and Cough-Related Research
- Bioactive natural compounds
- Proteoglycans and glycosaminoglycans research
- Glutathione Transferases and Polymorphisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Skin Protection and Aging
- Cell Adhesion Molecules Research
- Smoking Behavior and Cessation
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Calpain Protease Function and Regulation
- Immunotherapy and Immune Responses
- Safe Handling of Antineoplastic Drugs
- Hereditary Neurological Disorders
- Histiocytic Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Children's Physical and Motor Development
- Eicosanoids and Hypertension Pharmacology
University of Minnesota, Duluth
2023
Jeju National University
2023
Ulsan College
2019-2020
Asan Medical Center
2019-2020
University of Ulsan
2019-2020
Inha University Hospital
2020
Kennesaw State University
2017-2018
The Ohio State University
2017
Ajou University
2007-2016
Pukyong National University
2015
Melanogenesis is a critical self-defense mechanism against ultraviolet radiation (UVR)-induced skin damage and carcinogenesis; however, dysregulation of melanin production distribution causes skin-disfiguring pigmentary disorders.Melanogenesis initiated by UVR-induced cAMP generation ensuing activation transcription factor CREB, which induces expression the master melanogenic regulator MITF.Recent studies have demonstrated that recruitment CRTCs to CREB complex also required for...
<b><i>Background/Aims:</i></b> Studies on determinants of bone mineral density (BMD) among Asian middle-aged and older men are very limited. The aim this study was to investigate general dietary factors influencing BMD in Korean men. <b><i>Methods:</i></b> This conducted using data from the 2008-2010 Korea National Health Nutrition Examination Survey. A total 2,305 male subjects aged 50-79 years were included. Whole-body, femur, femoral neck,...
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this a pivotal process that used to maintain mitochondrial homeostasis. Although dysregulation of dynamics related the pathogenesis several human diseases, its molecular mechanism not fully elucidated. In study, we demonstrate potential role miR-27 in regulation dynamics. fission factor (MFF) mRNA direct target miR-27, whose ectopic expression decreases MFF through binding...
Introduction Digital technology has created opportunities for delivering smoking cessation assistance at the population level. However, efficacy of sending multiple, automated, tailored emails providing motivation, support and information quitting is unknown. Methods Smokers planning to quit (n=1070) were randomly assigned (1) 27 (deluxe email group (DEG)), (2) 3 4 with links downloadable booklets (basic (BEG)) or (3) a single non-tailored (single (SEG)). All included resources....
The high abundance of mitochondria and the expression mitochondrial uncoupling protein 1 (UCP1) confer upon brown adipose tissue (BAT) unique capacity to convert chemical energy into heat at expense ATP synthesis. It was long believed that BAT is present only in infants, so, it not considered as a potential therapeutic target for metabolic syndrome; however, discovery metabolically active adult humans has re-stimulated interest contributions regulation dysfunction health disease. Here we...
Abstract Syndecan‐1 is one of the major proteoglycans on cell surfaces involved in biological processes. Although loss syndecan‐1 correlates well with gain cancerous characteristics a wide range cancers, increased expression also coincides adverse outcomes some including breast, ovarian and pancreatic cancers. For this Janus‐faced attitude syndecan‐1, we sought to examine patterns endometrial carcinoma (EC) insight into roles syndecan‐1. Immunohistochemical examinations 109 tissue samples...
Abstract Hypoxia–reperfusion injury is one of the major risk factors for neurodegeneration. However, it unclear whether ischaemic damage in brain microvascular endothelial cells plays roles neurodegeneration, particularly amyloidogenic changes contributing to development Alzheimer’s disease (AD) pathologies. Therefore, we investigated hypoxia–reoxygenation (H/R)-induced release high mobility group box protein 1 (HMGB1), a molecule AD pathogenesis damaged brain, from human (HBMVECs) neuronal...
Background/Objectives: This study evaluated the clinical utility of a virtual reality (VR)-based kitchen error task for children (VKET-C) to assess functional cognition in children. Methods: In total, 38 aged 7–12 years were included, comprising 23 typically developing (TD) and 15 with developmental disabilities (DDs), including autism spectrum disorder, attention deficit hyperactivity intellectual disability. While performing VKET-C, performance errors analyzed. The Stockings Cambridge...
We previously reported that Eriobotrya japonica (EJ) improves the cognitive dysfunction caused by amyloid-β (Aβ) peptide injection. Here, we further examined possible neuroprotective effects and combined ameliorating of EJ Salvia miltiorrhiza Bunge (SM) in various vitro vivo models. confirmed a mixture 5% ethanol extract from leaves (EJE) water SM roots (SMW) on Aβ1–42-induced toxicity an model. Treatment with (1:1) (Mix) produced significantly better protection cells Aβ-induced more...
Abstract A two‐stage genomewide association ( GWA ) analysis was conducted to investigate the genetic factors influencing ultraviolet UV )‐induced skin pigmentation in Korean females after exposure. Previously, a study evaluating ~500 000 single nucleotide polymorphisms SNP s) 99 identified eight s that were highly associated with tanning ability. To confirm these associations, we genotyped an independent replication (112 females). We found novel intron of WW domain‐containing oxidoreductase...
Among several classes ofphenolic compounds, a group with the core structure of C6-C3-C6 is named flavonoids (benzo-γ-pyran derivatives),consisting phenolic and pyran rings. According to theoxidation state ring, can be furthersubdivided into five major subclasses as follows: flavonols,flavanols, flavones, isoflavones, anthocyanidins.
The purpose of this study was to determine the staining conditions and appropriate fan1 start time (FAN1ST) for Sysmex SP-50 produce blood smears (BS) that reflect true lymphocyte morphology patient samples.
The biology of cells transplanted with bone grafts is incompletely understood. Focusing on the early angiogenic response postgrafting, we report a mouse femur graft model in which were derived from mice transgenic for firefly luciferase (FLuc) bioluminescence reporter gene driven by promoter signaling molecule vascular endothelial growth factor (VEGF). Upon transplantation into wild-type (wt) mice, vivo imaging (BLI) permitted longitudinal visualization and measurements VEGF activity...
Glutathione (GSH) is a chief cellular antioxidant, affecting stem cell functions. The GSH level dynamically altered by the redox buffering system and transcription factors, including NRF2. Additionally, differentially regulated in each organelle. We previously reported protocol for monitoring real-time levels live cells using reversible sensor FreSHtracer. However, GSH-based analysis needs be comprehensive organelle-specific. Hence, this study, we demonstrate detailed to measure regeneration...
This study was aimed to implement the electroglottography (EGG) system for analyzing fundamental frequency of phonation. EGG recorded from conductance between ring electrodes attached neck skin area near thyroid cartilage with high carrier electric signals during vocalization, and voice signal microphone simultaneously. were transmitted audio port in PC stereo sound recording program. From digitized data, several parameters such as pitch, jitter, shimmer, CQ SQ analyzed vowel sounds. For...