A5102809964- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Occupational exposure and asthma
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Contact Dermatitis and Allergies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Antifungal resistance and susceptibility
- Eosinophilic Disorders and Syndromes
- Nasal Surgery and Airway Studies
- Healthcare and Venom Research
- Food Allergy and Anaphylaxis Research
- Mast cells and histamine
- Indoor Air Quality and Microbial Exposure
- Respiratory Support and Mechanisms
- Entomological Studies and Ecology
- Restraint-Related Deaths
- Lung Cancer Diagnosis and Treatment
- Eosinophilic Esophagitis
- Venous Thromboembolism Diagnosis and Management
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2019
National Institutes of Health
2019
University of Connecticut
2019
Dr Youth Clinic
2014
Soonchunhyang University Hospital
2003-2011
Soonchunhyang University
1996-2011
University of Colorado Denver
2005-2008
National Jewish Health
2005-2008
Korea Occupational Safety and Health Agency
2006
Ajou University
2002-2003
Rationale: Severe respiratory syncytial virus (RSV) bronchiolitis has been associated with deficient IFN-γ production in humans, but the role of this cytokine determining outcome reinfection is unknown.Objectives: To define development RSV-mediated airway hyperresponsiveness (AHR) and lung histopathology mice.Methods: Wild-type (WT) knockout mice were infected RSV newborn or weaning stages reinfected 5 weeks later. Airway responses assessed on Day 6 after primary secondary...
Eosinophil and mast cell infiltrations are consistent findings in nasal polyp tissue. Previous studies have shown that matrix metalloproteinases (MMPs) may be involved eosinophil infiltration airway mucosa of asthmatic patients, transforming growth factor-beta1 (TGF-beta1) induces extracellular deposition The aim this study was to evaluate the role MMPs tissue-inhibitor metalloproteinase-1 (TIMP-1) association with TGF-beta1, eosinophils activation Nasal tissues from 20 patients who...
<i>Background:</i> Airway eosinophilia is frequently observed during acute exacerbation of asthma. Interleukin-5 (IL-5) and eotaxin are directly involved in the airway found persistent Interrelation between these cytokines expected to occur Thus, we evaluated relevance interaction IL-5 inflammation exacerbation. <i>Methods:</i> We measured number inflammatory cells amount sputum from 22 healthy subjects, 21 asthmatics with 16 patients mild asthma, reassessed values 7...
Leukotriene receptor antagonists (LTRAs) are used to treat aspirin-intolerant asthma (AIA); however, the protective effects of long-term LTRA administration against aspirin-induced bronchospasm have not been evaluated.We investigated efficacy a 12-week treatment with in protecting AIA patients.Fifty-two adult patients underwent an aspirin challenge test just before montelukast (10 mg/day) and after 12 weeks treatment. The effect was assessed as disappearance results were compared according...
Abstract Background: Chitinase may play a role in regulating allergic diseases. Objective: We studied the of chitinase mouse model exposed to diesel exhaust particles (DEP). Mice were intranasal DEP (0.6 mg/mL) for 5 days and challenged with aerosolized (6 mg/m 3 ) on 6–8. Enhanced pause (Penh), as an airway obstruction marker, was measured day 9, bronchoalveolar lavage (BAL) fluid lung tissues collected 10. The expression Ym1 Ym2 mRNA assessed tissue extracts by reverse...
Patients with Asthma: Is There a Difference between Elderly and Non-Elderly Patients?Depression is an important comorbidity of asthma.However, little information available about depression its potential impact on asthma control in Korean adult patients.We aimed to estimate the prevalence risk factors for adults persistent asthma.The 127 non-elderly (20-64 yr) 75 elderly ( ≥ 65 patients were recruited.Demographic clinical data extracted, completed Asthma Specific Quality Life (AQOL)...
To confirm local production of IgE, and evaluate role immunoglobulins on eosinophil activation in nasal polyp (NP) tissue, we measured IgG, IgA, secretory IgA(sIgA), total (tIgE) specific IgE (sIgE) to Dermatophagoides pteronyssinus(DP) by ELISA NP tissue homogenates from 51 subjects. They were classified according skin reactivity DP: group I, 15 highly atopic subjects; II, 18 weakly III, non-atopic Eosinophil cationic protein (ECP) level was CAP system. Highest DP-sIgE noted followed II III...
The mechanism and cause of acute eosinophilic pneumonia are largely unknown. Many factors including the smoking cigarettes have been suggested, but none proven to directly pneumonia. authors report a case in young Asian male who recently started smoking. diagnosis was made based on his clinical course results chest radiography, lung spirometry, bronchoalveolar lavage, transbronchial biopsies. After administration methylprednisolone, rapidly improved. A provocation test designed establish...
The crude drug “Siberian Ginseng (SG)” has long been used in empirical Oriental medicine for the nonspecific enhancement of resistance humans and animals. In this study, we investigated effect cell cultured SG by oral administration mast cell-mediated allergic reactions. dose-dependently inhibited compound 48/80-induced systemic allergy with doses 10−2 to 1 g/kg h before administration. Of special note, dose 25%. (1 g/kg) also passive cutaneous reaction 51%. histamine release from rat...
This investigation was designed to confirm IL-8 production from human bronchial epithelial cells with toluene diisocyanate (TDI) exposure and examine the effects of pro-inflammatory cytokine dexamethasone. We cultured Beas-2B, a cell line TDI-HSA conjugate compared those without conjugate. in supernatant measured by ELISA. To evaluate effect proinflammatory cytokines, peripheral blood mononuclear (PBMC) were collected TDI- non-TDI asthma patients, added culture. Dexamethasone or antibodies...