A5100721354- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- RNA Interference and Gene Delivery
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Virus-based gene therapy research
- Reproductive Biology and Fertility
- Global Cancer Incidence and Screening
- Nutritional Studies and Diet
- Thyroid Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Nutrition and Health in Aging
- Radiopharmaceutical Chemistry and Applications
- Thyroid and Parathyroid Surgery
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Ovarian cancer diagnosis and treatment
Soonchunhyang University
2015-2025
Bucheon University
2015-2025
Montefiore Medical Center
2025
Korea Institute of Radiological and Medical Sciences
2015-2024
Samsung (South Korea)
2024
Hannam University
2024
Seoul Medical Center
2023
Catholic University of Korea
2015-2023
National Cancer Center
2019-2023
The Ohio State University
2023
Though antimicrobial peptides (AMPs) show great potential as novel antibiotics, therapeutic applications are hindered by their low stability, toxicity and high manufacturing cost. Various chemical modification strategies employed to overcome these problems. However, modifications often significantly increase the cost of AMPs with only limited pharmacokinetic advantages. Therefore, we developed enhanced stability cell specificity that can be economically produced. Peptides were designed...
The optimal combination of anesthetic agent and technique may have an influence on long-term outcomes in cancer surgery. In vitro vivo studies suggest that propofol independently reduces migration cells metastasis. Thus, the authors retrospectively examined link between propofol-based total intravenous anesthesia (TIVA) recurrence or overall survival patients undergoing modified radical mastectomy (MRM).A retrospective analysis electronic database all MRM for breast January 2007 December...
The production of recombinant therapeutic proteins is one the fast-growing areas molecular medicine and currently plays an important role in treatment several diseases. Yeasts are unicellular eukaryotic microbial host cells that offer unique advantages producing biopharmaceutical proteins. capable robust growth on simple media, readily accommodate genetic modifications, incorporate typical post-translational modifications. Saccharomyces cerevisiae a traditional baker's yeast has been used as...
Abstract This study aimed to investigate the predictive efficacy of positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) for pathological response advanced breast cancer neoadjuvant chemotherapy (NAC). The PET/MRI image deep learning model was introduced compared with conventional methods. PET/CT MRI parameters were evaluated before after first NAC cycle in patients [n = 56; all women; median age, 49 (range 26–66) years]. maximum standardized uptake...
To determine the updated long-term outcomes of Addition Ovarian Suppression to Tamoxifen in Young Women With Hormone-Sensitive Breast Cancer Who Remain Premenopausal or Regain Vaginal Bleeding After Chemotherapy (ASTRRA) trial.This study is a post-trial follow-up ASTRRA trial, involving 1,483 premenopausal women younger than 45 years treated with definitive surgery after completing adjuvant neoadjuvant chemotherapy for estrogen receptor-positive breast cancer. Patients were randomly assigned...
Abstract Climate change has driven the need for carbon capture to mitigate anthropogenic greenhouse gas emissions, yet current thermochemical methods are hampered by high energy intensities. Electrochemically mediated (EMCC) utilizing redox‐active dioxide (CO 2 ) carriers is an attractive alternative capture. Here, economical vat dye compound, indigo, presented, which can reversibly and release CO upon electrochemical reduction oxidation, respectively. Electrode electrolyte engineering...
PURPOSE The addition of ovarian function suppression (OFS) for 5 years to tamoxifen (TAM) treatment premenopausal patients with breast cancer after completion chemotherapy has beneficial effects on disease-free survival (DFS). This study evaluated the efficacy adding 2 OFS TAM in hormone receptor–positive who remain a state or resume chemotherapy. PATIENTS AND METHODS We enrolled 1,483 women (age ≤ 45 years) estrogen treated definitive surgery completing adjuvant neoadjuvant Ovarian was...
Although radiotherapy resistance is associated with locoregional recurrence and distant metastasis in breast cancers, clinically relevant molecular markers critical signaling pathways of radioresistant cancer are yet to be defined. Herein, we show that HER2-STAT3-survivin regulation HER2-positive cancers. Depletion HER2 by siRNA sensitized cells irradiation decreasing STAT3 activity survivin, a target gene, expression cells. Furthermore, inhibition activation or depletion survivin also...
BACKGROUND “Atypia of undetermined significance” (AUS) in the Bethesda System for Reporting Thyroid Cytopathology is a heterogeneous category cases that cannot be easily classified into benign, suspicious, or malignant. This study evaluated whether cytomorphology‐based subcategorization could better predict malignancy risk designated as AUS, and how subcategories correlated with BRAF mutation status thyroid fine‐needle aspirates (FNA). METHODS Of 3589 FNA diagnosed at authors' institution...
Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its activity not well understood. In present study, we investigated combined effects melatonin and arsenic trioxide (ATO) on cell death human breast cancer cells. enhanced ATO-induced apoptotic via changes protein levels Survivin, Bcl-2, Bax, thus affecting cytochrome c release from mitochondria to cytosol. Interestingly, found that induced by co-treatment with ATO was...
The Korean Breast Cancer Society (KBCS) has reported a nationwide breast cancer data since 1996. We present comprehensive report on the facts and trends of in Korea 2013. Data newly diagnosed patients year 2013 were collected from 99 hospitals by using questionnaire survey. Clinical characteristics such as stage cancer, histologic types, biological markers, surgical management obtained online registry database. A total 19,316 with crude incidence rate female including carcinoma situ was 76.2...
In this study, we identify the local structures of ex-solved nanoparticles using machine-learned potentials (MLPs). We develop a method for training by sampling heterointerface configurations as set with its efficacy tested on Ni/MgO system, illustrating that error in interface energy is only 0.004 eV/Å2. Using developed scheme, train an MLP Ni/La0.5Ca0.5TiO3 ex-solution system and both exo- endo-type particles. The established model aligns well experimental observations, accurately...
Although Smad2 and Smad3, critical transcriptional mediators of transforming growth factor-beta (TGF-beta) signaling, are supposed to play a role in the TGF-beta cytostatic program, it remains unclear whether delivers signals through both Smads equally or either differentially. Here, we report that rely on Smad3-, but not Smad2-, dependent pathway intensity can be modulated by changing endogenous ratio Smad3 Smad2. Depleting RNA interference sufficiently interfered with actions various...