A5101779332- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Breast Cancer Treatment Studies
- Cardiac tumors and thrombi
- Breast Lesions and Carcinomas
- Metabolism, Diabetes, and Cancer
- Acute Myocardial Infarction Research
- Inflammatory Bowel Disease
- Pancreatic function and diabetes
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Thyroid Cancer Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Knee injuries and reconstruction techniques
- Health and Well-being Studies
- Neurofibromatosis and Schwannoma Cases
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Anomaly Detection Techniques and Applications
- Health and Wellbeing Research
- Cardiovascular Function and Risk Factors
- HER2/EGFR in Cancer Research
- Breast Implant and Reconstruction
Sangmyung University
2021-2025
Pusan National University Hospital
2024
Ansan University
2023
Korea University
2023
Seoul National University
2023
Gachon University Gil Medical Center
2023
McMaster University
2021
Wonkwang University
2016-2017
Mokpo National University
2016-2017
National Development Institute of Korean Medicine
2016-2017
To investigate the significance of immunohistochemical molecular subtyping, we evaluated outcomes subtypes based on estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), and Ki-67. Using tissue microarrays, 1006 breast cancer patients between November 1999 August 2005 were categorized into four subtypes: luminal A (ER+ and/or PR+, HER2-, Ki-67 < 14%), B ≥ 14% or ER+ HER2+), HER2-enriched (ER-, PR-, triple-negative (TNBC) HER2-). Demographics, recurrence patterns,...
Response to neoadjuvant chemotherapy is a significant prognostic factor for osteosarcoma; however, this information can be determined only after surgical resection. If we could predict histologic response before surgery, it might helpful the planning of surgeries and tailoring treatment. We evaluated usefulness (18)F-FDG PET purpose.A total 70 consecutive patients with high-grade osteosarcoma treated at our institute were prospectively enrolled. All underwent MRI chemotherapy. analyzed...
Abstract Background The receptor activator of nuclear factor κB ligand (RANKL/TNFSF11) is expressed in metastatic bone cancer cells and has been suggested to play a key role cell migration behavior. We determined whether RANKL expression correlated clinical behavior localized, high‐grade osteosarcoma. Patients methods This retrospective, immunohistochemical study was performed using materials obtained from 40 patients treated at Korea Cancer Center Hospital between 1995 2007. Prechemotherapy...
Although a substantial role for 5′ adenosine monophosphate-activated protein kinase (AMPK) has been established in regulating cardiac metabolism, less studied action of AMPK is its ability to prevent cell death. Using activators like dexamethasone (DEX) or metformin (MET), the objective present study was determine whether activation prevents tumour necrosis factor-alpha (TNF-α) induced apoptosis adult rat ventricular cardiomyocytes. Cardiomyocytes were incubated with DEX, MET, TNF-α varying...
<i>Objective:</i> To determine the feasibility of stereotactic body radiotherapy (SBRT) using 3 fractions for isolated colorectal lung metastases. <i>Methods:</i> From June 2003 to December 2006, 13 cases pulmonary metastasis from cancer were treated by SBRT due an inoperable state (7 patients), or patient’s refusal undergo surgical excision (6 patients). All patients underwent chemotherapy salvage treatment. doses ranged 39 51 Gy in fractions. Nine had a solitary...
Glucocorticoids increase pyruvate dehydrogenase kinase-4 (PDK4) mRNA and protein expression, which phosphorylates dehydrogenase, thereby preventing the formed from undergoing mitochondrial oxidation. This in PDK4 expression is mediated by mandatory presence of Forkhead box other factors (FoxOs) nucleus. In current study, we examined importance nongenomic effects dexamethasone (Dx) determining compartmentalization FoxO hence its transcriptional activity. Rat cardiomyocytes exposed to Dx...
Although several clinicopathologic parameters may be related to metastasis-free survival in osteosarcoma, the importance of prognostic factors with time is largely unknown. Therefore, we asked whether clinical characteristics patients osteosarcoma metastasis after 2 years differed from those an earlier metastatic event. We retrospectively reviewed 420 Stage IIB treated surgery and chemotherapy. The minimum followup was 3 months (mean, 71.4 months; range, 3-257 months). Among patients, 167...
Ezrin, a cytoskeleton linker protein, has been reported to be involved in the metastasis of solid tumors animal models and patients small clinical studies. We analyzed relationship between immunohistochemical expression ezrin prognosis osteosarcoma. retrospectively identified 64 with Stage IIB osteosarcomas 1995 2000. Tissue microarrays were constructed from incisional biopsy specimens staining was performed. Ezrin other clinicopathologic variables such as age, gender, pathologic subtype,...
The aim of this study was to investigate whether stereotactic body radiotherapy (SBRT) can salvage gastric cancer patients with para-aortic lymph node (PALN) recurrence. From January 2003 December 2006, 7 were treated for isolated PALN recurrence from after curative resection. Follow up durations ranged 19 33 months (median; 26 months), and SBRT doses 45 Gy 51 (median 48 Gy) in 3 fractions. Disease progression-free overall survivals toxicities recorded. Response treatment assessed by...
Heparanase, which specifically cleaves carbohydrate chains of heparan sulfate, has been implicated in the pathology diabetes-associated complications. Using high glucose (HG) to replicate hyperglycaemia observed following diabetes, present study was designed determine mechanism by HG initiates endothelial heparanase secretion.To examine effect on heparanase, bovine coronary artery cells were incubated with 25 mM glucose. Strategies using different agonists and antagonists used behind...
Although gut microbiome dysbiosis has been associated with inflammatory bowel disease (IBD), the relationship between oral microbiota and IBD remains poorly understood. This study aimed to identify unique patterns in saliva from patients explore potential microbial markers for differentiating Crohn's (CD) ulcerative colitis (UC). A prospective cohort recruited (UC: n = 175, CD: 127) healthy controls (HC: 100) analyze their using 16S rRNA gene sequencing. Machine learning models (sparse...
Recently, significant research efforts have been directed toward leveraging Artificial Intelligence for sensor data processing and system control. In particular, it is essential to determine the optimal path trajectory by calculating effective control systems. For instance, model-predictive based on Proportional-Integral-Derivative models intuitive, efficient, provides outstanding performance. However, challenges in tracking persist, which requires active development integrate optimize terms...
Following diabetes, the heart increases its lipoprotein lipase (LPL) at coronary lumen by transferring LPL from cardiomyocyte to endothelial lumen. We examined how hyperglycemia controls secretion of heparanase, enzyme that cleaves myocyte heparan sulphate proteoglycan initiate this movement. Diazoxide (DZ) was used decrease serum insulin and generate hyperglycemia. A modified Langendorff technique separate interstitial effluent, which were assayed for heparanase LPL. Within 30 min DZ,...