A5082320712- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Inflammatory Bowel Disease
- Galectins and Cancer Biology
- Tracheal and airway disorders
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Cancer-related molecular mechanisms research
- Biliary and Gastrointestinal Fistulas
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
Genome and Company (South Korea)
2021-2025
University Gastroenterology
2023
New Generation University College
2005-2022
Incheon St. Mary's Hospital
2022
Catholic University of Korea
2022
Soonchunhyang University
2010-2022
Seoul Metropolitan Government
2022
National University College
2022
The mammalian translational initiation machinery is a tightly controlled system that composed of eukaryotic factors, and which controls the recruitment ribosomes to mediate cap-dependent translation. Accordingly, mTORC1 complex functionally this translation through phosphorylation its downstream substrates 4E-BPs S6Ks. It generally accepted rapamycin, specific inhibitor mTORC1, potent repressor. Here we report unexpected discovery rapamycin's ability regulate varies significantly among cell...
Since the Korean College of Helicobacter and Upper Gastrointestinal Research has first developed guideline for diagnosis treatment pylori infection in 1998, revised was proposed 2009 by same group. Although made comprehensive review previous articles consensus authoritative expert opinions, evidence-based developmental process not applied revision guideline. This new been especially terms changes indication H. Korea, adaptation as method; 6 guidelines were retrieved systematic Appraisal...
Gastric neuroendocrine tumors (GNETs), once rare, have become more prevalent due to the increased use of endoscopy and physician awareness. The clinical characteristics long-term outcomes GNET management were explored in this study.
This study was performed to investigate the effectiveness of gastric cancer (GC) screening methods in a community-based prospective cohort Korean Multi-center Cancer Cohort (KMCC) with over 10-year follow-up.A total 10,909 and 4,773 subjects from KMCC information on gastroendoscopy (GE) upper gastrointestinal series (UGIS) were included this study. Cox proportional hazard model adjusted for age, sex, Helicobacter pylori infection, cigarette smoking, alcohol drinking used estimate ratios...
Yoon Jin Choi, Yong Chan Lee, Jung Mogg Kim, Il Jeong Seop Moon, Yun Lim, Gwang Ho Baik, Byoung Kwan Son, Hang Lak Kyoung Oh Nayoung Kwang Hyun Ko, Hye-Kyung Jung, Ki-Nam Shim, Hoon Jai Chun, Byung-Wook Hyuk Jie-Hyun Hyunsoo Chung, Sang Gyun and Jae Young Jang. Gut Liver 2022;16:535-46. https://doi.org/10.5009/gnl220055
Abstract We have developed previously a class of synthetic hybrid histone deacetylase (HDAC) inhibitors, which were built from hydroxamic acid trichostatin A and pyridyl ring MS-275. In this study we evaluated the antitumor effects these novel HDAC SK-7041 SK-7068, on human cancer cells. Both SK-7068 effectively inhibited cellular activity at nanomolar concentrations induced time-dependent hyperacetylation histones H3 H4. These inhibitors preferentially enzymatic activities HDAC1 HDAC2, as...
Abstract Background Preoperative accurate diagnosis of the T and N stages in early gastric cancer (EGC) is important determining application various limited treatments. The aim this study to analyze accuracy staging EGC with esophagogastroduodenoscopy (EGD), Stomach protocol CT (S‐CT), endoscopic ultrasonography (EUS), factors influencing accuracy. Methods Four hundred thirty‐four patients preoperatively diagnosed as using EGD or S‐CT undergoing curative gastrectomy at Seoul National...
Abstract Background and Aims: Although triple combination therapy containing a proton pump inhibitor (PPI) two antibiotics is considered as standard regimen for the first‐line anti‐ Helicobacter pylori treatment, there are still debates on ideal duration of treatment. The aim this study was to compare efficacies 7‐day 14‐day PPI‐containing therapy. Materials Methods: This performed in randomized, multicenter, prospective manner. After upper gastrointestinal endoscopy, H. ‐infected patients...
Purpose: This study aimed to analyze the effect of screening by using endoscopy on diagnosis and treatment gastric cancer.Materials Methods: The clinicopathologic characteristics cancer were compared in individuals who underwent an because symptoms (non-screening group) or for purposes (screening group).The distributions stages modalities 2006 2011 compared.Results: proportion patients group increased from 45.1% 65.4% (P<0.001).The stage I cancers entire patient sample also (from 60.5% 70.6%...
Sang Gyun Kim, Chan Mi Park, Na Rae Lee, Jiyoung Da Hyun Lyu, Seung-Hee Il Ju Choi, Wan Sik Seun Ja Jae Jun Ji Chul-Hyun Lim, Joo Young Cho, Gwang Ha Yong Hwoon-Yong Jung, Haeng Hoon Jai Chun, and Sang-Yong Seol. Gut Liver 2018;12:402-10. https://doi.org/10.5009/gnl17414
Tegoprazan is a novel, fast- and long-acting potassium-competitive acid blocker that suppresses gastric secretion, which could benefit patients with non-erosive reflux disease (NERD), type of gastroesophageal disease.To evaluate the efficacy safety profiles tegoprazan compared those placebo in Korean NERD.In this phase 3, double-blind, placebo-controlled, multicentre study, 324 NERD were randomised into three treatment groups: 50 mg, 100 mg placebo. These drugs provided once daily for 4...
Recently, a novel intestinal bacterial metabolite of ginseng protopanaxadiol saponins, i.e., 20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol (IH-901), has been reported to induce apoptosis in variety cancer cells. Here we show differential effect IH-901 on several cell types. Exposure for 48 hours at supposedly subapoptotic concentration 40 mumol/L led both apoptotic death and G1 arrest Hep3B cells, but only resulted MDA-MB-231, Hs578T, MKN28 Additionally, the treatment not Hep3B, with...
Changes in the pattern of gastrointestinal diseases a population tend to be influenced by changes diet and lifestyle. Shifts disease from 1995 2005 Korea were evaluated, retrospectively.Seventeen nationwide medical centers participated this study. The cross-sectional review endoscopic findings 28 893 patients included 8441 1995, 10 350 2000, 102 2005.The prevalence reflux esophagitis increased 1.8% 5.9% 2000 9.1% (P<0.001, P value was only for comparison between 2005, followings as same)....
Background/Aims: Irritable bowel syndrome (IBS) is a troublesome disease.Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS.Methods: IBS patients who met Rome III criteria were randomly assigned receive composite or placebo.A total 20 billion lyophilized bacteria administered twice daily for 8 weeks.Primary outcome variables...