The biosimilar of infliximab, CT-P13, has recently been shown to be equivalent infliximab in both efficacy and safety the treatment rheumatologic diseases. However, no data are available with respect drug's patients inflammatory bowel disease (IBD). We aimed assess CT-P13 IBD patientsThis was a retrospective multicenter study including anti-tumor necrosis factor (TNF) naïve who switched from biologic originator CT-P13.In anti-TNF Crohn's (CD) (n = 32), clinical response remission rates were...

Colorectal adenoma is known to be associated with obesity, but the association between colorectal and visceral adipose tissue (VAT) area measured by abdominal computed tomography (CT) has not been documented clearly. In addition, relationship insulin resistance adenomas, which underlies mechanism that links obesity adenoma, studied extensively. The aim of this study was examine VAT as risk factors adenoma.A cross-sectional, case-control conducted in Koreans presented for health check-ups....

Colorectal cancer (CRC) screening is the most efficient strategy to reduce disease-related mortality. Frequent aberrant DNA methylation known occur in selected genes and early during CRC development, which has emerged as a new epigenetic biomarker for detection of CRC. Previously, we reported that identified CpG sites SDC2 were aberrantly methylated tumor tissues patients through comprehensive analysis demonstrated high potential quantification blood colorectal cancer. In this study, aim...

There are several studies considering obesity as the risk factor for various lower gastrointestinal symptoms. But relationship between visceral abdominal and incidence of irritable bowel syndrome (IBS) is not studied yet. The aim this study was to investigate association adipose tissue (VAT) IBS.This a case-control comparing VAT area subjects with IBS (IBS group) controls without (non group), who underwent abdomen computerized tomography (CT) routine health checkup from January 2012 August...

Background/Aims: Irritable bowel syndrome (IBS) is a troublesome disease.Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS.Methods: IBS patients who met Rome III criteria were randomly assigned receive composite or placebo.A total 20 billion lyophilized bacteria administered twice daily for 8 weeks.Primary outcome variables...

Purpose: Esophageal candidiasis (EC) is the most frequent opportunistic fungal infection in immunocompromised host.However, we have found EC healthy individuals through esophagogastroduodenoscopy (EGD).The aim of this study was to determine prevalence and risk factors for individuals. Materials Methods:We retrospectively reviewed medical records 281 patients who had been incidentally diagnosed with EC.We also conducted age sex matched case control identify factor EC.Results: The 0.32%...

To investigate prevalence and risk factors for colorectal neoplasms in adults aged < 50 years, whom screening is not recommended.This cross-sectional study compared characteristics of advanced adenomas patients years who underwent colonoscopy with subjects ≥ years. evaluate adenoma young adults, we used multivariable logistic regression models. Colorectal neoplasm were evaluated those older patients.Among 2819 included, prevalences 19.7% 1.5%, respectively. As patient age increased, so did...

To investigate the clinical characteristics of adverse events (AEs) after COVID-19 vaccination in patients South Korea.Data from Korean Disease Control and Prevention Agency on AEs 4 vaccines, including AZD1222, BNT162b2, JNJ-78436735, mRNA-1273, February 26, 2021, to August 21, were assessed. The epidemiological characteristics, symptoms, severity, complications, mortality descriptively analyzed.Overall, 36.3 million individuals who completed doses during study period included, 153,183...

Background and Aim: Despite the low incidence of perforation after endoscopic procedures in colon, increasing use these is likely to cause a commensurate increase such problems. This study was undertaken determine iatrogenic define clinical characteristics, assess management complications. Methods: A retrospective review medical records performed for all patients with colon perforations endoscopy between January 2000 June 2007. Results: Over this 7-year period, total 20,660 sigmoidoscopies,...

Background: The use of warfarin is growing for the prevention or treatment cardiovascular cerebrovascular diseases. risk haemorrhagic side effects increased in patients taking warfarin. Aims: To evaluate risks related with withholding and resuming anticoagulation upper gastrointestinal bleeding (UGIB) while on therapy role second-look endoscopic examination (SEE). Methods: Records 58 native valvular heart diseases who presented non-variceal UGIB during chronic were retrospectively reviewed....

Percutaneous endoscopic gastrostomy (PEG) is carried out commonly for patients with dysphagia. Clinicians, however, are often reluctant to carry PEG in the elderly because of concerns about complications and short life expectancy. The present study aimed assess safety patients.The medical records 116 who received from October 2005 May 2012 were reviewed retrospectively. Among them, 63 aged 65 years older (the group), 53 less than younger group).Baseline characteristics showed no significant...

Abstract Background and Aim A biosimilar of infliximab, CT‐P13 (Remsima®) has the potential to reduce treatment costs enhance access biological therapy for inflammatory bowel disease (IBD) patients. However, long‐term clinical data on its use IBD are currently sparse. We aimed investigate efficacy safety in a large, real‐life cohort. Methods total 368 patients (227 with Crohn's [CD] 141 ulcerative colitis [UC]) treated at 16 referral hospitals Korea between July 2012 December 2017 were...

Aims Metabolic syndrome (MS) is a global health problem associated with an increased risk of diabetes mellitus (DM), cardiovascular disease (CVD), and cancer. Body composition parameters, including obesity, visceral adiposity, sarcopenia contribute to the development MS CVD. Previous studies have investigated association individual body parameters MS. Studies analyzing between multiple been rare. We aimed investigate sarcopenia. Methods A total 13,620 subjects who underwent voluntary routine...

There is limited data that supports a role for vegetarian diet in nonalcoholic fatty liver disease (NAFLD). The aim of this study to evaluate the relationship between diets and NAFLD, considering metabolic syndrome obesity.This cross-sectional, retrospective comparing prevalence NAFLD 615 Buddhist priests age-, sex-, Body mass index (BMI)-and presence/absence syndrome-matched controls who underwent routine health checkups promotion center. Diagnosis severity was determined based on...

Abstract Background The relationship between visceral adiposity and the incidence of functional dyspepsia (FD) has not yet been studied. purpose present study is to evaluate association risk FD. Methods This a case–control that compares abdominal adipose tissue area subjects with FD control without FD, who underwent abdomen computerized tomography (CT) for health examinations in tertiary center. Retrospectively, telephone survey was conducted diagnose using Rome III criteria. We measured...

Gallbladder polyps (GBP) are a common clinical finding and may possess malignant potential. We conducted this study to determine whether visceral obesity is risk factor for GBP.We retrospectively reviewed records of subjects who received both ultrasonography computed tomography with measurements the areas adipose tissue total (TAT) on same day as health checkups.Ninety-three 1,615 (5.8%) had GBP were compared 186 age- sex-matched controls. VAT (odds ratio [OR], 2.941; 95% confidence interval...

Although there are general guidelines on endoscopic biopsy for diagnosing gastric neoplasms, they predominantly based outdated literature obtained with fiberscopes without analyses specific to tumor characteristics. This study aims comprehensively characterize the contemporary by determining diagnostic yield across different lesion morphologies and histological stages, especially exploring how number site of may influence overall yield. Biopsy samples from suspected neoplasms were collected...

Gastrostomy TubesWhen replacing percutaneous endoscopic gastrostomy (PEG) tubes, an internal bolster may be retrieved either percutaneously or endoscopically.The aim of this study was to compare the complications and method during PEG tube replacement.The medical records 330 patients who received replacement were retrospectively analyzed.According removal bolster, we categorized as group group.Demographic data, procedurerelated risk factors investigated.There 176 cases (53.3%) in 154 (46.7%)...