A5056628655- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Mycobacterium research and diagnosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Autoimmune and Inflammatory Disorders
- Gut microbiota and health
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Gastrointestinal motility and disorders
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Anorectal Disease Treatments and Outcomes
- Cytomegalovirus and herpesvirus research
Seoul National University
2016-2025
Seoul National University Hospital
2015-2025
Midland College
2024
Michigan State University
2024
National University College
2023
New Generation University College
2009-2023
Soongsil University
2023
Catholic University of Korea
2018-2019
CHA Gangnam Medical Center
2018-2019
CHA University
2018-2019
Although the incidence of inflammatory bowel disease [IBD] is increasing in Asia, data on long-term epidemiological trends are limited. We performed a 30-year longitudinal study to investigate temporal epidemiology Crohn's [CD] and ulcerative colitis [UC] Seoul, Korea.This population-based included 1431 IBD patients [418 CD, 1013 UC] diagnosed between 1986 2015 Songpa-Kangdong district Korea. Temporal incidence, prevalence, phenotype at diagnosis were analysed.The adjusted mean annual rates...
Objective: To evaluate the safety and efficacy of CT-P13 (Remsima®) in patients with inflammatory bowel disease (IBD) South Korea. Methods: This post-marketing study included active moderate-to-severe Crohn's (CD), fistulizing CD (FCD), or ulcerative colitis (UC) treated followed for 30 weeks. Assessments treatment-emergent adverse events (TEAEs) disease-specific clinical response remission. Results: No unexpected TEAEs were observed 173 recruited to date. occurred 18.1, 16.7, 26.9% CD, FCD,...
Background and Aims: Inflammatory bowel disease (IBD) may be associated with anxiety depression. The aim of this study was to evaluate the incidence depression in patients IBD compared general population. Methods: A nationwide population-based cohort conducted using claims data from National Healthcare Insurance service Korea. We between 15,569 46,707 non-IBD controls, age sex matched at a ratio 1:3. Results: During mean follow-up six years, experienced significantly more (12.2% vs. 8.7%; p...
The association of diabetes with inflammatory bowel disease (IBD) remains unclear. risk in patients IBD compared non-IBD controls was investigated. Using the National Health Insurance database South Korea, 8070 based on International Classification Disease 10th revision (ICD-10) codes and rare intractable for Crohn’s (CD) ulcerative colitis (UC) were 40,350 individuals (2010–2014). Newly diagnosed identified using ICD-10 prescription anti-diabetic medication by end follow-up period (2016)...
Background and Aims: It is not known whether inflammatory bowel disease (IBD) enhances the risk of Parkinson's (PD) or PD diagnosis result increased health care use. We determined developing among patients with IBD in terms medication Methods: A nationwide population-based study was conducted using claims data from Korean National Health Insurance service. From 2010 to 2013, Crohn's (CD) ulcerative colitis (UC) were identified through both International Classification Disease, Tenth Revision...
Objective Dysfunctional resolution of intestinal inflammation and altered mucosal healing are essential features in the pathogenesis inflammatory bowel disease (IBD). Intestinal macrophages vital process resolution, but mechanisms underlying their capacity remain elusive. Design We investigated role prostaglandin E 2 (PGE ) receptor PTGER4 on differentiation patients with IBD mouse models inflammation. studied epithelial barrier regeneration Csf1r-iCre Ptger4 fl/fl mice during dextran...
Abstract Background Previous epidemiologic studies have suggested that increased consumption of ultra-processed food (UPF) can increase the risk developing inflammatory bowel disease (IBD) by exacerbating gut dysbiosis.1 However, directly linking UPF to specific microbial shift in IBD patients are limited. Our study explored differences microbiota profile based on intake with IBD. Methods This multi-centre cohort included 313 from three hospitals. Patients were divided into four quartiles...
Abstract Background Preoperative accurate diagnosis of the T and N stages in early gastric cancer (EGC) is important determining application various limited treatments. The aim this study to analyze accuracy staging EGC with esophagogastroduodenoscopy (EGD), Stomach protocol CT (S‐CT), endoscopic ultrasonography (EUS), factors influencing accuracy. Methods Four hundred thirty‐four patients preoperatively diagnosed as using EGD or S‐CT undergoing curative gastrectomy at Seoul National...
Infliximab is currently used for the treatment of moderate-to-severe ulcerative colitis (UC) with an inadequate response to conventional agents. The efficacy and safety infliximab in Korean patients UC were assessed.This was a retrospective multicenter study including all adult who received at least one infusion UC. Short- long-term clinical outcomes adverse events therapy evaluated, predictors identified.A total 134 included. indications acute severe 28%, steroid-dependency 38%,...
To estimate the risk of end-stage renal disease (ESRD) in patients with inflammatory bowel (IBD).From January 2010 to December 2013, Crohn's (CD) and ulcerative colitis (UC) were identified, based on both International Classification Diseases, 10th revision (ICD-10) rare, intractable registration program codes from National Health Insurance (NHI) database South Korea. We compared 38812 IBD age- sex-matched non-IBD controls a ratio 1:3. Patients newly diagnosed ESRD identified ICD-10...
Background/Aims: Irritable bowel syndrome (IBS) is a troublesome disease.Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS.Methods: IBS patients who met Rome III criteria were randomly assigned receive composite or placebo.A total 20 billion lyophilized bacteria administered twice daily for 8 weeks.Primary outcome variables...
Although infliximab is widely accepted as a therapeutic option for inflammatory bowel disease, its efficacy the treatment of intestinal Behçet’s disease (BD) unknown. We investigated short-term and long-term response rates to in BD predictive factors sustained following treatment. This study was conducted using retrospective noncontrolled review medical records from 8 tertiary hospitals Korea. collected clinical, demographic, laboratory data patients with 28 who received at least 1 dose...
The clinical impact of video capsule endoscopy (VCE) in patients with obscure gastrointestinal bleeding (OGIB) remains undetermined. aim this study was to evaluate the long-term VCE OGIB using a nationwide registry.Data from 305 who underwent for 13 hospitals Korea between January 2006 and March 2009 were analyzed. Prospectively collected registry data reviewed, follow-up by chart review telephone interviews patients. Multivariate regression analyses hazard ratios (HR) performed determine...
Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis Crohn's disease. In this study, we investigated clinical characteristics and disease outcome patients with varying levels NF-κB activation.Crohn's who underwent surgical bowel resection were divided into two groups, based on status NF-κB. was assessed by immunoreactivity during immunohistochemical staining specimens. We compared demographic, histologic between groups. Furthermore, occurrence...
The aims of this study were to investigate whether acid suppressive therapy increases the risk spontaneous bacterial peritonitis (SBP) and define factors associated with mortality in cirrhotic patients SBP.Cirrhotic who had undergone paracentesis after hospitalization included. Those divided into two groups according presence or absence SBP. Factors development SBP analyzed. Mortality rates during within 30 days also analyzed.A total 1140 (median age, 62; men, 75%; model for end-stage liver...
Aberrant gene expression in the gut mucosa might contribute to initiation and progression of Crohn's disease (CD). RNA sequencing (RNA-seq) provides precise measurements levels transcripts their isoforms. The aim this study was use RNA-seq investigate transcriptomic differences identify significantly differentially expressed inflamed noninflamed intestinal CD patients.RNA-seq performed on 13 pairs from patients sex-matched normal healthy controls. Significantly were validated by...