A5051679091- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Caveolin-1 and cellular processes
- Diagnosis and treatment of tuberculosis
- Gastrointestinal Tumor Research and Treatment
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Surgical Treatments
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Eosinophilic Esophagitis
- Cancer-related molecular mechanisms research
- Gastrointestinal disorders and treatments
- Tuberculosis Research and Epidemiology
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- Cancer-related Molecular Pathways
Kyung Hee University
2016-2025
Kyung Hee University Dental Hospital
2013-2024
Chungbuk National University Hospital
2023
Korea Photonics Technology Institute
2023
Seoul National University
2022
New Generation University College
2022
Yonsei University
2010-2021
Gwangju Institute of Science and Technology
2014-2018
Dong-Eui University
2013
Hallym University
2011
Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis.We conducted two integrated randomized, double-blind, placebo-controlled trials in patients with active disease. In the trial induction therapy, 374 (cohort 1) received (at a dose 300 mg) or placebo intravenously at weeks 0 and 2, 521 2) open-label disease evaluation week 6. maintenance either cohort who had response to 6 were randomly assigned continue receiving every 8...
Abstract Mutational alterations of PTEN and PIK3CA , which negatively positively regulate PI3‐kinase activity, respectively, have been observed in many types human cancer. To explore the implication mutations gastric tumorigenesis, we characterized expression mutation status genes 126 tissues 15 cell lines. Expression transcript was abnormally low 5 (33%) lines 20 55 (36%) primary carcinomas, whereas 0 71 noncancerous including 16 benign tumors showed altered expression. Allelotyping...
Abstract Background MitoQ is a mitochondria-targeted derivative of the antioxidant ubiquinone, with and anti-apoptotic functions. Reactive oxygen species are involved in many inflammatory diseases including bowel disease. In this study, we assessed therapeutic effects mouse model experimental colitis investigated possible mechanisms underlying its on intestinal inflammation. Methods levels mitochondrial function were measured blood mononuclear cells patients The evaluated dextran sulfate...
Colorectal cancer is the second most common in males and fourth females Korea. Since of colorectal occur through prolonged transformation adenomas into carcinomas, early detection removal are one effective methods to prevent cancer. Considering increasing incidence polyps Korea, it very important establish Korean guideline for screening polyp detection. Multi-Society Take Force developed guidelines with evidence-based methods. Parts statements drawn by systematic reviews meta-analyses....
Now colorectal cancer is the second most common in males and fourth females Korea. Since of cancers occur after prolonged transformation adenomas into carcinomas, early detection removal are one effective methods to prevent cancer. Considering increasing incidence polyps Korea, it very important establish Korean guideline for screening polyp detection. The was developed by Multi-Society Take Force we tried evidence-based methods. Parts statements were draw systematic reviews meta-analyses....
Infliximab is currently used for the treatment of moderate-to-severe ulcerative colitis (UC) with an inadequate response to conventional agents. The efficacy and safety infliximab in Korean patients UC were assessed.This was a retrospective multicenter study including all adult who received at least one infusion UC. Short- long-term clinical outcomes adverse events therapy evaluated, predictors identified.A total 134 included. indications acute severe 28%, steroid-dependency 38%,...
Abstract Gut dysbiosis is closely associated with the occurrence of inflammatory bowel disease (IBD) and psychiatric disorder. Here, to understand difference gut microbiota composition physiological effect between IBD patients (IBD/D + ) or without depression − ), we analyzed fecal (/D healthy volunteers (HVs) examined effects these transplantations (FMTs) on systemic inflammation anxiety/depression in mice. FMTs from IBD/D caused IBD-like colitis transplanted mice: they increased...
Abstract Gut dysbiosis is closely associated with the outbreak of inflammatory bowel disease (IBD) and psychiatric disorder. The Enterobacteriaceae population was higher in feces patients (IBD-F) than those healthy control volunteers (HC-F). Enterococcaceae Lactobacillaceae populations were IBD depression (IBD/D + -F) vs. without − -F). Therefore, we examined effects Klebsiella oxytoca, Escherichia coli, Cronobacter sakazakii, Enterococcus faecium, Pediococcus acidolactici overpopulated...
Patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC), show an increased incidence of anxiety and depression; however, the association between UC-associated psychiatric disorders gut microbiota is unclear. This study aimed to examine whether from patients UC can alter colonic gene expression, leading anxiety- depression-like behavior in mice receiving fecal transplantation (FMT). RNA sequencing transcriptome analyses revealed a difference expression FMT (UC-FMT...
Abstract Interleukin‐1B and IL‐1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL‐1B ‐511T polymorphism the GC Asians. We tested for loci mucosal levels IL‐1β developing a Korean population. Polymorphisms IL‐1A ‐889, ‐31, ‐511 IL‐1RN were genotyped 434 controls 234 patients GC. Mucosal cytokine was measured using ELISA. The frequencies IL‐1A, ‐511,...
AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection saline alone for large colon polyps by conventional polypectomy.
Although infliximab is widely accepted as a therapeutic option for inflammatory bowel disease, its efficacy the treatment of intestinal Behçet’s disease (BD) unknown. We investigated short-term and long-term response rates to in BD predictive factors sustained following treatment. This study was conducted using retrospective noncontrolled review medical records from 8 tertiary hospitals Korea. collected clinical, demographic, laboratory data patients with 28 who received at least 1 dose...
We conducted a nationwide validation study of diagnostic algorithms to identify cases inflammatory bowel disease (IBD) within the Korea National Health Insurance System (NHIS) database.Using NHIS dataset, we developed 44 combining International Classification Diseases (ICD)-10 codes, codes for Rare and Intractable (RID) registration claims data health care encounters, pharmaceutical prescriptions IBD-specific drugs. For each algorithm, compared case identification results from electronic...
Although symptomatic propylthiouracil (PTU)-induced hepatic injury is known to be rare, there have been few reports about its exact incidence in patients with hyperthyroidism. We tried evaluate a single center and clinical course.Medical records of 912 hyperthyroid who had diagnosed between March 1990 December 1998 were reviewed characteristics, management, laboratory findings. Symptomatic PTU-induced was defined as the development jaundice or hepatitis symptoms at least 3-times elevation...
Abstract Background and Aim: The number of patients with ulcerative colitis (UC) in Korea has increased. In addition, the colorectal cancer (CRC) associated UC also Therefore, this population‐based nationwide study was conducted to investigate incidence CRC compare these results those studies other countries. Methods: Korean Association for Study Intestinal Diseases (KASID) reviewed 7061 cases that occurred between 1970 2005 found a total 26 CRC. Results: overall prevalence 0.37%. estimated...
The incidence of colorectal cancer is increasing in Korea, but the epidemiology neoplasm not clearly defined. We aimed to elucidate prevalence average-risk Koreans and explore underlying risk factors.A large-scale, multicenter, prospective study was conducted. Of 19,460 subjects who underwent colonoscopy at 11 university hospitals, we analyzed 3,951 consecutive asymptomatic adults with no factors for cancer.The were aged 52.1+/-11.6 years (mean+/-SD) 60.1% them men. prevalences advanced...
Common endoscopic findings in stomachs with Helicobacter pylori infections include antral nodularity, thickened gastric folds, and visible submucosal vessels. These are suggestive but not diagnostic of H. infection. Magnifying endoscopy can reveal more precisely the abnormal mucosal patterns an pylori-infected stomach; however, it requires training, expertise, time. We aimed to establish a new classification for predicting by non-magnifying standard alone.A total 617 participants who...
Post-polypectomy surveillance has become a major indication for colonoscopy as result of increased use screening in Korea. However, because the medical resource is limited, and first produces greatest effect on reducing incidence mortality colorectal cancer, there need to increase efficiency postpolypectomy surveillance. In present report, careful analytic approach was used address all available evidences delineate predictors advanced neoplasia at colonoscopy. Based results review evidences,...
Summary Background The association between antibiotic use and risk of inflammatory bowel disease (IBD), particularly among adults, remains unclear. Furthermore, there is a scarcity data non‐Western countries. Aims To investigate the dose–response relationships subsequent IBD across all ages Methods This population‐based case–control analysis used from Korean National Health Insurance Service database (2004–2018). We compared 68,633 patients with new‐onset to matched controls ( n = 343,165)...
A positive family history is an increased risk factor for gastric cancer within members, and one of the possible causes this intrafamilial clustering Helicobacter pylori infection. Our study examined prevalence H. infection, serum antibodies to CagA VacA atrophic gastritis and/or intestinal metaplasia in offspring or siblings patients. total 726 subjects included 300 relatives separate patients 426 controls. All underwent upper gastrointestinal endoscopic examination with a rapid urease...