A5027007415- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
- Cancer therapeutics and mechanisms
- Muscle metabolism and nutrition
- PI3K/AKT/mTOR signaling in cancer
- Adipose Tissue and Metabolism
- Tuberculosis Research and Epidemiology
- Inflammasome and immune disorders
- Signaling Pathways in Disease
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Aldose Reductase and Taurine
- RNA Research and Splicing
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Cancer Treatment and Pharmacology
- Macrophage Migration Inhibitory Factor
Yonsei University
2012-2025
USA Mitchell Cancer Institute
2016-2024
University of South Alabama
2016-2024
Severance Hospital
2021
Kyung Hee University
2010-2016
Kyung Hee University Medical Center
2012
University of California, San Francisco
2012
Kyung Hee University East-West Neo Medical Center
2009
Cheju Halla University
2006
Inje University Sanggye Paik Hospital
2003
Abstract EGFR exon 20 insertion driver mutations (Exon20ins) in non–small cell lung cancer (NSCLC) are insensitive to tyrosine kinase inhibitors (TKI). Amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR–MET, has shown preclinical activity TKI-sensitive EGFR-mutated NSCLC models and an ongoing first-in-human study patients with advanced NSCLC. However, the of amivantamab Exon20ins-driven tumors not yet been described. Ba/F3 cells patient-derived cells/organoids/xenograft...
Abstract Background MitoQ is a mitochondria-targeted derivative of the antioxidant ubiquinone, with and anti-apoptotic functions. Reactive oxygen species are involved in many inflammatory diseases including bowel disease. In this study, we assessed therapeutic effects mouse model experimental colitis investigated possible mechanisms underlying its on intestinal inflammation. Methods levels mitochondrial function were measured blood mononuclear cells patients The evaluated dextran sulfate...
Abstract B7-H3 is a member of B7 family immunoregulatory transmembrane glycoproteins expressed by T cells. While overexpression associated with poor outcomes in multiple cancers, it also has immune-independent roles outside cells and its precise mechanistic contributions to cancer are unclear. In this study, we investigated the role metabolic reprogramming vitro vivo. We found that promoted Warburg effect, evidenced increased glucose uptake lactate production B7-H3–expressing protein levels...
Mitochondrial oxidative damage is thought to play a key role in pancreatic β-cell failure the pathogenesis of type 2 diabetes. Despite this, potential mitochondria-targeted antioxidants protect β-cells against stress has not yet been studied. Therefore, we investigated if such as RINm5F and HIT-T15 cells under glucotoxic glucolipotoxic conditions. When were incubated these conditions, expression levels mitochondrial electron transport chain complex subunits, antioxidant enzymes (such MnSOD...
Osimertinib is an oral, third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and EGFR T790M-resistance mutations with lower activity against wild-type has demonstrated efficacy in non-small cell lung cancer (NSCLC) CNS metastases. The sensitizing mutations, the in-frame deletions exon 19 L858R point mutation 21, represent between 80% 90% of all mutations. remaining 10% to 20% are referred as...
Cyclophilin B (CypB) performs diverse roles in living cells, but its role hepatocellular carcinoma (HCC) is largely unclear. To reveal HCC, we investigated the induction of CypB under hypoxia and functions tumor cells vitro vivo. Here, demonstrated that hypoxia-inducible factor 1α (HIF-1α) induces hypoxia. Interestingly, protected even p53-defective HCC against hypoxia- cisplatin-induced apoptosis. Furthermore, it regulated effects HIF-1α, including those angiogenesis glucose metabolism, via...
The Warburg effect, which reflects cancer cells' preference for aerobic glycolysis over glucose oxidation, contributes to tumor growth, progression and therapy resistance. restraint on pyruvate flux into mitochondrial oxidative metabolism in cells is part attributed the inhibition of dehydrogenase (PDH) complex. Src a prominent oncogenic non-receptor tyrosine kinase that promotes cell proliferation, invasion, metastasis resistance conventional targeted therapies. However, potential role...
Many studies have reported that the generation of reactive oxygen species (ROS) increases during differentiation muscle-derived C2C12 cells. Peroxiredoxin-2 (Prx-2) is an abundant mammalian enzyme protects against oxidative stress. However, role Prx-2 in muscle has not been investigated.In this study, we demonstrated expression and regeneration response to exogenous H(2)O(2). This increase occurs only myoblast cell lines because no was observed NIH3T3, MEF, Chang, or HEK293 lines. The...
Doxorubicin (DOX) is a chemotherapeutic drug that used to treat many cancers, but its use limited by cardiotoxic side effect. Carbonyl reductase 1 (CBR1) an NADPH-dependent oxidoreductase reduces DOX doxorubicinol (DOXOL), less potent derivative responsible for cardiotoxicity. Thus, we aimed demonstrate inhibition of CBR1 enhances the efficacy and attenuates cardiotoxicity.Pharmacological or genetic improved anticancer effects in preclinical models breast cancer. RNA interference chemical...
Osimertinib is a third-generation EGFR tyrosine kinase inhibitor (TKI) that approved for the use of EGFR-mutant non-small cell lung cancer (NSCLC) patients. In this study, we investigated acquired resistance mechanisms in NSCLC patients and patient-derived preclinical models.Formalin-fixed paraffin-embedded tumor samples plasma from 55 who were treated with osimertinib collected at baseline progressive disease (PD). Next-generation sequencing was performed using 600-gene hybrid capture panel...
The B7-H3 protein, encoded by the CD276 gene, is a member of B7 family proteins and transmembrane glycoprotein. It highly expressed in various solid tumors, such as lung breast cancer, has been associated with limited expression normal tissues poor clinical outcomes across different malignancies. Additionally, plays crucial role anticancer immune responses. Antibody-drug conjugates (ADCs) are promising therapeutic modality, utilizing antibodies targeting tumor antigens to selectively...
Abstract Arsenic trioxide (As2O3) is used, in current practice, as an effective chemotherapeutic agent for acute promyelocytic leukemia (APL). However, the side effects and relatively low efficacy of As2O3 treating other leukemias have limited its wider use therapeutic applications. In present study, we found that expression carbonyl reductase 1 (CBR1) affects resistance to leukemias, including APL; upregulated CBR1 at transcriptional level by stimulating activity transcription factor...
Hepatitis C virus (HCV) is a major cause of end-stage liver disease. Direct-acting antivirals (DAAs), including inhibitors nonstructural proteins (NS3/4A protease, NS5A, and NS5B polymerase), represent key components anti-HCV treatment, but these are associated with increased drug resistance toxicity. Thus, the development host-targeted antiviral agents, such as cyclophilin A inhibitors, an alternative approach for more effective, selective, safer treatment. Starting discovery bis-amide...
It has been reported that high-fat, high-carbohydrate (HFHC) meals increase oxidative stress and inflammation. We examined whether repeated intake of excess energy in the form HFHC alters reactive oxygen species (ROS) generation expression levels antioxidant enzymes mitochondrial proteins mononuclear cells, to determine this is associated with insulin resistance. recruited healthy lean individuals ( n 10). The were divided into two groups: one group 5) ingested 10878·4 kJ/d (2600 kcal/d;...
Nuclear factor-κB (NF-κB) is a critical transcription factor for maximal expression of many the cytokines that are involved in pathogenesis inflammatory diseases. In this study, we found pinosylvin, natural stilbenoid component pine leaf (Pinus densiflora), significantly inhibited LPS-induced NF-κB activation concentration-dependent manner. Additionally, pinosylvin was to inhibit phosphorylation and degradation IκB α THP-1 cells. Therefore, have attempted determine whether can possessing...