A5060112395- Adipose Tissue and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Veterinary medicine and infectious diseases
- Toxic Organic Pollutants Impact
- Facial Rejuvenation and Surgery Techniques
- Dermatology and Skin Diseases
- Thermoregulation and physiological responses
- Body Contouring and Surgery
- Lymphatic System and Diseases
- Cancer-related Molecular Pathways
- Lipid metabolism and disorders
- Skin Protection and Aging
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Dermatologic Treatments and Research
- Zebrafish Biomedical Research Applications
- Birth, Development, and Health
- MicroRNA in disease regulation
- Carcinogens and Genotoxicity Assessment
- Genetic and rare skin diseases.
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Pesticide Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
Chonnam National University
2018-2024
Asan Medical Center
2014-2023
University of Ulsan
2014-2023
Ulsan College
2014-2023
National Police Hospital
2019-2022
Inha University
2019-2021
Myongji Hospital
2018
Seonam University
2018
Korea Institute of Human Resources Development
2016
Yonsei University
2014-2016
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by complex, heterogeneous pathogenesis including barrier dysfunction, immunology, and pruritus. Although epidermal growth factor (EGF) essential for epithelial homeostasis wound healing, the effect of EGF on AD remains to be explored. To develop new therapy AD, anti-AD potential was investigated inducing AD-like lesions in NC/Nga mice using 2,4-dinitrochlorobenzene (DNCB). administrated evaluate its therapeutic...
Demand for noninvasive body contouring has increased.We evaluated the efficacy and safety of a thermal high-intensity focused ultrasound (HIFU) device abdominal shaping.Adults with mass index ≤30 kg/m an subcutaneous fat tissue thickness ≥2.5 cm were enrolled HIFU treatment at energy levels 150 J/cm (first session) 135 (second session). The primary end point was change from baseline waist circumference post-treatment Week 8. Secondary points were: changes in weight, waist/hip ratio, assessed...
Sarcopenia, which refers to the muscle loss that accompanies aging, is a complex neuromuscular disorder with clinically high prevalence and mortality. Despite many efforts protect against weakness atrophy, incidence of sarcopenia its related permanent disabilities continue increase. In this study, we found treatment human placental hydrolysate (hPH) significantly increased viability (approximately 15%) H 2 O ‐stimulated C2C12 cells. Additionally, while cells showed irregular morphology, hPH...
The B7-H3 protein, encoded by the CD276 gene, is a member of B7 family proteins and transmembrane glycoprotein. It highly expressed in various solid tumors, such as lung breast cancer, has been associated with limited expression normal tissues poor clinical outcomes across different malignancies. Additionally, plays crucial role anticancer immune responses. Antibody-drug conjugates (ADCs) are promising therapeutic modality, utilizing antibodies targeting tumor antigens to selectively...
Background: Oxidative stress and photodamage resulting from ultraviolet radiation exposure play key roles in skin aging. Fermented Cyclopia intermedia, which is used to brew honeybush tea, exerts antioxidant anti-wrinkle effects by inhibiting reactive oxygen species production downregulating matrix metalloproteinase activity. Objectives: This randomized, double-blinded, placebo-controlled study aimed evaluate the efficacy safety of fermented (Cyclopia intermedia) extract (HU-018) for...
Persistent organic pollutants (POPs) are lipid-soluble toxins that not easily degraded; therefore, they accumulate in the environment and human body. Several studies have indicated a correlation between POPs metabolic diseases; however, their effects on mitochondria as central organelle cellular metabolism usage of functional markers for disease barely understood. In this study, zebrafish model system was exposed to two subclasses POPs, organochlorine pesticides (OCPs) polychlorinated...
We sought to investigate the influence of extent myocardial injury on left ventricular (LV) systolic and diastolic function in patients after reperfused acute infarction (AMI). Thirty-eight AMI underwent cardiac magnetic resonance (CMR) imaging percutaneous coronary revascularization. The edema scarring were assessed by T2 weighted late gadolinium enhancement (LGE) imaging, respectively. Within a day CMR, echocardiography was done. Using 2D speckle tracking analysis, LV longitudinal,...
Mitochondrial metabolism plays a crucial role in insulin resistance and secretion type 2 diabetes mellitus (T2D). Some studies have focused on how Cassia tora extracts affect hyperglycemia. However, the effects of mitochondrial dysfunction associated with not been well explained. In this study, well-known effective compounds extracted from using 70% ethanol were administered to high-fat diet (HFD) fed mouse examine ethanolic (CSEE) pancreas. Furthermore, we examined CSEE regulates basal...
Background and Objectives Ultraviolet light‐emitting diodes (UV‐LEDs) are a novel light source for phototherapy. This research investigated the in vitro safety efficacy of UV‐LEDs as phototherapeutic device atopic dermatitis (AD). Study Design/Materials Methods Human keratinocytes fibroblasts were irradiated by with center wavelength 310 340 nm. We examined effects UV‐LED irradiation on suppression TNF‐α/IFN‐γ‐induced activation STAT1 ICAM‐1 NF‐κB expression; we used following methods: cell...
Increasing clarithromycin resistance has led to the need for an alternative first-line therapy eradication of Helicobacter pylori (H. pylori) in Korea, and bismuth containing quadruple (BQT) tailored (TT) have been proposed as regimens. The aim this study was compare rates BQT TT H. therapies.H. infection diagnosed using rapid urease test or dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR) during endoscopy. Patients positive were divided into two groups; those...
Dear Editor: A 58-year-old woman presented with multiple tiny papules having comedo-like openings on her face (Fig. 1A). Three years previously, she had received gold acupuncture permanent needles for facial skin rejuvenation that was performed by an unlicensed acupuncturist. After the procedure, treatment site swollen 3 months. At same site, a pungent odor appeared. Punch biopsies were lesions in infraorbital and forehead areas to confirm diagnosis of epidermal cysts associated...
I1 Proceedings of the 4th World Conference on Research Integrity Concurrent Sessions: 1. Countries' systems and policies to foster research integrity CS01.1 Second time around: Implementing embedding a review responsible conduct policy practice in an Australian research-intensive university Susan Patricia O'Brien CS01.2 Measures promote university: case Asian Danny Chan, Frederick Leung 2. Examples education programmes different countries CS02.1 Development state-run "cyber program ethics"...
Summary Background The safety and wrinkle‐reducing effects of multipolydioxanone (PDO) scaffold have been confirmed in animal, clinical tests for 3 months, but the 12‐month outcomes, are unknown. Objective efficacy multi‐PDO were tested animal models humans 12 months. Methods In study, a was implanted into panniculus carnosus rat dorsal skin (n = 18) subcutaneous layer minipig 2) followed by histological staining analysis. human deep periosteal under wrinkles on upper lips forehead,...
Lysozyme is an antibacterial enzyme that found in most of body fluids. tears plays a primary role protecting eye from harmful environments; if lysozyme degraded or inhibited, eyes are likely to be more vulnerable bacterial infection. In this study, activity was evaluated according varying concentrations heavy metals, copper, zinc, cobalt and manganese light metal, calcium frequently airborne particulate matters assayed using dyequenching substrate, Micrococcus lysodeikticus. Less...
Type 2 diabetes (T2D) is characterized by defects in insulin action to target tissues, resulting hyperglycemia, resistance, and mitochondrial dysfunction. The eye one of the organs susceptible T2D, but knowledge regarding dysfunction eyes after hyperglycemia T2D based mainly on epidemiological evidence, with little experimental data. Persistent organic pollutants (POPs) are known as endocrine-disrupting chemicals associated uncontrolled glucose lipid metabolism, leading onset diabetes. To...
Abstract Cassia tora is an annual herb, which has pharmacological effects such as antioxidant, hypolipidemic, and antidiabetic effects. Accordingly, its effect on diabetes been well-studied. However, it unclear whether mitochondrial dysfunction associated with diabetes. In this study, the of emodin rhein in C. seed ethanolic extract (ER/CSEE) retinal function were examined high-fat diet (HFD)-fed mice. HFD-fed mice exhibited decreased followed by compensatory increase expression levels...