A5053106594- Air Quality and Health Impacts
- Occupational exposure and asthma
- Asthma and respiratory diseases
- Climate Change and Health Impacts
- Occupational and environmental lung diseases
- Indoor Air Quality and Microbial Exposure
- Contact Dermatitis and Allergies
- Inhalation and Respiratory Drug Delivery
- Heavy Metal Exposure and Toxicity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Energy and Environment Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Air Quality Monitoring and Forecasting
- Pesticide Exposure and Toxicity
- Allergic Rhinitis and Sensitization
- Sulfur Compounds in Biology
- Occupational Health and Safety Research
- Academic integrity and plagiarism
- Noise Effects and Management
- Heavy metals in environment
- Nanoparticles: synthesis and applications
- Artificial Intelligence in Healthcare and Education
- Respiratory Support and Mechanisms
- Carcinogens and Genotoxicity Assessment
- Neonatal Respiratory Health Research
KU Leuven
2016-2025
University of Lubumbashi
2024
Universitair Ziekenhuis Leuven
2015-2022
Midlands State University
2022
Centre for Science and Environment
2016-2019
Directorate-General Joint Research Centre
2019
Vrije Universiteit Brussel
2016
Catholic University of America
2007-2016
Hasselt University
1993-2015
Ghent University Hospital
2015
Background — Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. Methods Results To assess to what extent how rapidly inhaled pollutant particles pass into systemic circulation, we measured, in 5 healthy volunteers, distribution of radioactivity after inhalation “Technegas,” an aerosol consisting mainly ultrafine 99m Technetium-labeled carbon (<100...
The mechanisms of particulate pollution-related cardiovascular morbidity and mortality are not well understood. We studied the passage radioactively labeled ultrafine particles after their intratracheal instillation. Hamsters received a single instillation 100 μ g albumin nanocolloid (nominal diameter ⩽ 80 nm) with Ci technetium-99m were killed 5, 15, 30, 60 min. In blood, radioactivity, expressed as percentage total body radioactivity per gram amounted to 2.88 ± 0.80%, 1.30 0.17%, 1.52...
Policy coordination is needed for global supply chains
The type of lung disease caused by metal compounds depends on the nature offending agent, its physicochemical form, dose, exposure conditions and host factors. fumes or gaseous forms several metals, e.g. cadmium (Cd), manganese (Mn), mercury (Hg), nickel carbonyl (Nl(CO)4, zinc chloride (ZnCl2), vanadium pentoxide (V2O5), may lead to acute chemical pneumonitis pulmonary oedema tracheobronchitis. Metal fume fever, which follow inhalation (Zn), copper (Cu) many others, is a poorly understood...
Pulmonary function analysis is an important tool in the evaluation of mouse respiratory disease models, but much controversy still exists on validity some tests. Most commonly used pulmonary variables humans are not routinely applied mice, and question which optimal for monitoring a particular model remains largely unanswered. Our study aimed to delineate potential restrictions existing techniques different determine common between mice. A noninvasive (unrestrained plethysmography) two...
Quantum dots (QDs) have numerous possible applications for in vivo imaging. However, toxicity data are scarce.To determine the acute of QDs with carboxyl surface coating (carboxyl-QDs) and amine (amine-QDs), we investigated inflammatory properties, tissue distribution, prothrombotic effects after intravenous injection.We performed particle characterization by transmission electron microscopy dynamic light scattering. Carboxyl-QDs amine-QDs were intravenously injected mice (1.44-3,600...
Particulate air pollution is associated with cardiovascular morbidity and mortality. To investigate this association, we studied the effect of ultrafine (60 nm) polystyrene particles on thrombus formation in a hamster model after intravenous intratracheal administration unmodified, carboxylate-polystyrene, or amine-polystyrene particles. Unmodified had no thrombosis up to 5 mg/kg. Carboxylate-polystyrene significantly inhibited at 500 100 μg/kg body weight but not 50 weight. In contrast,...
Pollution by particulates has consistently been associated with increased cardiovascular morbidity and mortality, but a plausible biological basis for this association is lacking.Diesel exhaust particles (DEPs) were instilled into the trachea of hamsters, blood platelet activation, experimental thrombosis, lung inflammation studied. Doses 5 to 500 micro g DEPs per animal induced neutrophil influx bronchoalveolar lavage fluid elevation protein histamine without lactate dehydrogenase release....
Exposure to fine ambient particulate matter (PM) has consistently been associated with increased morbidity and mortality. The relationship between exposure ultrafine particles (UFP) health effects is less firmly established. If UFP cause independently from coarser fractions, this could affect impact assessment of air pollution, which would possibly lead alternative policy options be considered reduce the disease burden PM. Therefore, we organized an expert elicitation workshop assess...
Abstract Background Numerous epidemiological studies have demonstrated adverse health effects of a sedentary life style, on the one hand, and acute chronic exposure to traffic-related air pollution, other. Because physical exercise augments amount inhaled pollutants, it is not clear whether cycling work in polluted urban environment should be encouraged or not. To address this conundrum we investigated if bicycle journey along busy commuting road would induce changes biomarkers pulmonary...
Numerous studies have shown a strong association between daily mortality and small particulate with diameter of <10 microm (PM10) air pollution, but the effects season not always been well characterised.To study shape short-term PM10 across seasons quintiles outdoor temperature.Daily data on (n = 354 357), temperature in Flanders, Belgium, from January 1997 to December 2003, were analysed warm versus cold periods year (April-September v October-March), as possible effect modifiers.There was...
The current authors evaluated whether a system of co-cultures relevant cells (pneumocytes (A549), macrophages (THP-1), mast (HMC-1) and endothelial (EAHY926)) would mimic the responses to particles with 50% cut-off aerodynamic diameter 10 μm (PM ) previously reported in vivo . role was considered special interest. Single cultures, bicultures (A549 + HMC-1 10:1 ratio; THP-1 2:1 ratio) tricultures 10:2:1 were exposed urban PM (24 h at 0, 10, 30 or 100 µg·cm −2 ). Additionally, EAHY926...
The aim of this study was to investigate the modulation an asthmatic response by titanium dioxide (TiO 2 ) or gold (Au) nanoparticles (NPs) in a murine model diisocyanate-induced asthma. On days 1 and 8, BALB/c mice received 0.3% toluene diisocyanate (TDI) vehicle acetone–olive oil (AOO) on dorsum both ears (20 μL). day 14, were oropharyngeally dosed with 40 μL NP suspension (0.4 mg·mL −1 (∼0.8 mg·kg TiO Au). later (day 15), oropharyngeal challenge 0.01% TDI 16, airway hyperreactivity (AHR),...
Abstract The term irritant‐induced (occupational) asthma ( IIA ) has been used to denote various clinical forms of related irritant exposure at work. causal relationship between exposure(s) and the development can be substantiated by temporal association onset symptoms a single or multiple high‐level irritants, whereas this only inferred from epidemiological data for workers chronically exposed moderate levels irritants. Accordingly, following phenotypes should distinguished within wide...