A5086638886- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Occupational exposure and asthma
- Indoor Air Quality and Microbial Exposure
- Respiratory and Cough-Related Research
- Air Quality and Health Impacts
- Inhalation and Respiratory Drug Delivery
- Dermatology and Skin Diseases
- Olfactory and Sensory Function Studies
- Drug-Induced Adverse Reactions
- Eosinophilic Esophagitis
- Mast cells and histamine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Insect and Pesticide Research
- IL-33, ST2, and ILC Pathways
- Urticaria and Related Conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Odor and Emission Control Technologies
- Pharmaceutical studies and practices
- Entomological Studies and Ecology
- Voice and Speech Disorders
- Climate Change and Health Impacts
- Ocular Surface and Contact Lens
Université de Strasbourg
2016-2025
Chest Diseases Hospital
2015-2025
Hôpitaux Universitaires de Strasbourg
2015-2024
Hôpital Civil, Strasbourg
2014-2024
Itasca Consultants (France)
2022-2024
Inserm
1997-2023
French Clinical Research Infrastructure Network
2023
University of Coimbra
2022
Mitochondrie, stress oxydant et protection musculaire
2012-2021
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2015-2020
The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a potential novel treatment option for HDM allergy-related asthma.To evaluate the efficacy and adverse events of SLIT vs placebo asthma exacerbations during an inhaled corticosteroid (ICS) reduction period.Double-blind, randomized, placebo-controlled trial conducted between August 2011 April 2013 in 109 European sites. included 834 adults with not well controlled by ICS or combination products, rhinitis. Key...
Relationships between indoor air quality (IAQ) found in schools and the allergic respiratory health of schoolchildren have been insufficiently explored. A survey was conducted a large sample classrooms primary France to provide objective assessments IAQ which young are exposed classrooms, relate exposure major pollutants asthma allergies schoolchildren.Concentrations fine particles with aerodynamic diameter ≤2.5 μm (PM(2.5)), nitrogen dioxide (NO(2)) three aldehydes were objectively assessed...
<h3>Importance</h3> Epicutaneous immunotherapy may have potential for treating peanut allergy but has been assessed only in preclinical and early human trials. <h3>Objective</h3> To determine the optimal dose, adverse events (AEs), efficacy of a patch treatment. <h3>Design, Setting, Participants</h3> Phase 2b double-blind, placebo-controlled, dose-ranging trial peanut-allergic patients (6-55 years) from 22 centers, with 2-year, open-label extension (July 31, 2012-July 2014; completed...
This consensus statement provides practical recommendations for specific inhalation challenge (SIC) in the diagnosis of occupational asthma. They are derived from a systematic literature search, census active European centres, Delphi conference and expert consensus. article details each step SIC, including safety requirements, techniques delivering agents, methods assessing interpreting bronchial responses. The limitations procedure also discussed. Testing should only be carried out...
In a house with cat furnishings, air-exchange rate, and the are all thought to influence airborne allergen. We carried out experiments using two separate rooms, modifying environment, applying different cleaning techniques, washing cat, analyze these sources design methods of reducing Airborne measurements were made cascade impactor two-site monoclonal antibody-based immunometric assay for allergen Fel d I. Within 30 min entering 30-m3 clean room itself was found increase I by 90 ng/m3....
<b><i>Background:</i></b> Diagnosis and immunotherapy of house-dust mite (HDM) allergy is still based on natural allergen extracts. The aim this study was to analyze commercially available <i>Dermatophagoides pteronyssinus</i> extracts from different manufacturers regarding composition content whether variations may affect their allergenic activity. <b><i>Methods:</i></b> Antibodies specific for several <i>D. pteronyssinus...
Summary Background The majority of fish‐allergic patients are sensitized to parvalbumin, known be the cause important IgE cross‐reactivity among fish species. Little is about importance allergens other than parvalbumin. Objective aim this study was characterize hitherto undefined in three commonly consumed species, cod, salmon and tuna, evaluate their for vitro IgE‐diagnosis addition parvalbumin gelatin. Methods Sixty‐two were diagnosed by clinical history, skin prick tests specific...
The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration develop multi-sectoral care pathways chronic respiratory diseases in European countries and regions.AIRWAYS-ICPs has strategic relevance the Union Health Strategy will add value existing public health knowledge by: 1) proposing common framework diseases, which facilitate comparability trans-national initiatives; 2) informing cost-effective policy development, strengthening particular...
Abstract The term irritant‐induced (occupational) asthma ( IIA ) has been used to denote various clinical forms of related irritant exposure at work. causal relationship between exposure(s) and the development can be substantiated by temporal association onset symptoms a single or multiple high‐level irritants, whereas this only inferred from epidemiological data for workers chronically exposed moderate levels irritants. Accordingly, following phenotypes should distinguished within wide...
One of the major concerns in practice allergy is related to safety procedures for diagnosis and treatment allergic disease. Management (diagnosis treatment) hypersensitivity disorders involves often intentional exposure potentially allergenic substances (during skin testing), deliberate induction office symptoms offending compounds (provocation tests) or application dangerous (allergy vaccine) sensitized patients. These situations may be associated with a significant risk unwanted, excessive...
Abstract Skin prick testing (SPT) in combination with the clinical history of patient is one important step diagnosis IgE‐mediated occupational allergies. However, skin test performance related to quality allergen extracts. The present consensus document was prepared by an EAACI Task Force consisting expert panel allergologists and physicians from Germany, Italy, Spain, France, Austria, Poland. All members were also involved data collection within European multicentre study STADOCA ( Sta...
Background We tested the hypothesis that specific molecular sensitization patterns correlate with clinical data/manifestation in a European peanut-allergic population characterized under common protocol. Methods Sixty-eight subjects and 82 tolerant controls from 11 countries were included. Allergy to peanut lowest symptom-eliciting dose was established by double-blind placebo-controlled food challenge all but anaphylactic subjects. Information of early or late (before after 14 years age)...
Summary Introduction An increased incidence of asthma has been reported among healthcare workers. The role quaternary ammonium compounds ( QAC s), commonly used in cleaning/disinfection products, not clearly defined. aim this study was to analyse associations between and occupational exposure disinfectants, especially s. Methods performed on a stratified random sample the various departments 7 settings. included: questionnaire, physical examination specific IgE assays. Occupational...