A5070409462- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Food Safety and Hygiene
- Occupational exposure and asthma
- Dermatology and Skin Diseases
- Eating Disorders and Behaviors
- Consumer Attitudes and Food Labeling
- Respiratory and Cough-Related Research
- Delphi Technique in Research
- Olfactory and Sensory Function Studies
- Parvovirus B19 Infection Studies
- Drug-Induced Adverse Reactions
- Bacterial Infections and Vaccines
- Psidium guajava Extracts and Applications
- Spinal Fractures and Fixation Techniques
- Vaccine Coverage and Hesitancy
- Genetically Modified Organisms Research
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Pelvic and Acetabular Injuries
- Breastfeeding Practices and Influences
- Nutrition, Health and Food Behavior
University Medical Center Utrecht
2014-2025
Utrecht University
2010-2025
Loma Linda University Medical Center
2024
Arrowhead Regional Medical Center
2024
Loma Linda University
2024
Heidelberg University
2018-2021
University Hospital Heidelberg
2018-2021
Wilhelmina Children's Hospital
2020
Tilburg University
2020
Diakonessenhuis hospital
2020
BackgroundFor adults, prevalence estimates of food sensitization (FS) and allergy (FA) have been obtained in a standardized manner across Europe. For children, such are lacking.ObjectivesTo determine the self-reported FA, FS, probable FA (symptoms plus IgE sensitization), challenge-confirmed European school-age children.MethodsData on were collected through screening questionnaire sent to random sample general population 7- 10-year-old children 8 centers phase I EuroPrevall study. Data FS...
Abstract Since the discovery of immunoglobulin E (IgE) as a mediator allergic diseases in 1967, our knowledge about immunological mechanisms IgE‐mediated allergies has remarkably increased. In addition to understanding immune response and clinical symptoms, allergy diagnosis management depend strongly on precise identification elicitors reaction. past four decades, innovations bioscience technology have facilitated production well‐defined, highly pure molecules for component‐resolved (CRD),...
Complaints of 'food allergy' are increasing. Standardized surveys IgE sensitization to foods still uncommon and multicountry rare. We have assessed food-associated allergens in different regions Europe using a common protocol.Participants from general populations aged 20-54 years eight European centres (Zurich, Madrid, Utrecht, Lodz, Sophia, Athens, Reykjavik Vilnius) were asked whether they had allergic symptoms associated with specific foods. Weighted samples those without then completed...
Background We tested the hypothesis that specific molecular sensitization patterns correlate with clinical data/manifestation in a European peanut-allergic population characterized under common protocol. Methods Sixty-eight subjects and 82 tolerant controls from 11 countries were included. Allergy to peanut lowest symptom-eliciting dose was established by double-blind placebo-controlled food challenge all but anaphylactic subjects. Information of early or late (before after 14 years age)...
Although food allergy has universally been found to impair HRQL, studies have significant differences in HRQL between countries, even when corrected for perceived disease severity. However, little is known about factors other than severity which may contribute food-allergic patients. Therefore, the aim of this study was identify predict patients and also investigate specific impact having experienced anaphylaxis being prescribed an EAI on HRQL.A total 648 European (404 adults, 244 children)...
The heterogeneity and lack of validation existing severity scores for food allergic reactions limit standardization case management research advances. We aimed to develop validate a score reactions.Following multidisciplinary experts consensus, it was decided allergy (FASS) with ordinal (oFASS) numerical (nFASS) formats. oFASS 3 5 grades were generated through expert nFASS by mathematical modeling. Evaluation performed in the EuroPrevall outpatient clinic cohort (8232 reactions) logistic...
Food allergy to peanut and soybean, both legumes, is highly prevalent. The consumption of other legumes legume protein isolates, some which may be considered novel foods, increasing. This lead an increase in sensitization pose a risk for legume-allergic (e.g. soybean) patients due cross-reactivity.This study investigated the frequency co-sensitization co-allergy between role different families.Six patient groups were included: (n = 30), soybean lupine green pea lentil 17), bean 9). IgE...
To the Editor, Atopic dermatitis (AD) and food allergy (FA) are common chronic diseases that have a major impact on quality of life socio-economic burden.1, 2 AD is strongly associated with development immunoglobulin E (IgE)-mediated FA.3-5 The immune response involves allergen specific T helper type cells inducing pro-inflammatory cytokine release, including interleukin (IL)-4 IL-13, thereby causing initiation B cell class switching to IgE (sIgE).4 Dupilumab, human monoclonal antibody...
BackgroundWalnut allergy is common across the globe, but data on involvement of individual walnut components are scarce.ObjectivesTo identify geographical differences in component sensitization Europe, explore cosensitization and cross-reactivity, assess associations clinical serological determinants with severity allergy.MethodsAs part EuroPrevall outpatient surveys 12 European cities, standardized evaluation was conducted 531 individuals reporting symptoms to walnut, all known assessed 202...
Scope We have tested the hypothesis that high fat foods such as chocolate induce reduced rates of gastric emptying in comparison to lower and this can impact uptake allergens subsequent reactions allergic patients. Methods results In four volunteers, magnetic resonance imaging was used measure a series nine doses either dark bars containing 35% or dessert 8% fat. Analysis showed mean rate decrease volume with an 0.33 ± 0.09 mL/min compared average increase 0.10 for bars. parallel, eight...
Background: Peanut (PN), tree nuts (TN) and fruits are frequent causes of food allergy (FA). TN believed to cause more severe reactions than fruits. However, there no studies comparing the severity PN, fruit within one patient group. Methods: Four‐hundred eleven adult patients referred our tertiary center with suspicion FA completed a standardized questionnaire. Patients typical history immunoglubulin E (IgE)‐mediated allergy, e.g. oropharyngeal symptoms (hazelnut, walnut, cashew nut) or...
<b><i>Background:</i></b> Hazelnut and apple are common causes of food allergy in Europe. In northern Europe, symptoms usually mild associated with cross-reactivity to the birch pollen allergen, Bet v 1. Mediterranean area, more frequently severe sensitization lipid transfer protein (LTP). This study compared patients anaphylactic versus reactions hazelnut The Netherlands, a birch-endemic respect 1-homologues (i.e. PR10-proteins) LTP....
Many children in the general population avoid food because of self-reported adverse reactions (AFR). Food avoidance can have negative consequences for well-being and nutritional status. This study aimed to investigate which factors are related behavior (10-13 yr old) from population.Questionnaires both mother child were sent participants Europrevall study: 164 with AFR 170 without AFRs. Spielberger state anxiety trait clinical parameters, such as severity reaction, specific IgE doctor's...
Pru p 3 and 7 have been implicated as risk factors for severe peach allergy. This study aimed to establish sensitization patterns five components across Europe in Japan, explore their relation pollen foods predict symptom severity.In twelve European (EuroPrevall project) one Japanese outpatient clinic, a standardized clinical evaluation was conducted 1231 patients who reported symptoms and/or were sensitized peach. Specific IgE against 1, 2, 3, 4 Cup s measured 474 of them. Univariable...
Abstract Background Data on the impact of number and nature perceived asthma triggers health‐related quality life ( HRQL ) in children are scarce. Objective To investigate both asthma‐specific generic children. Methods A cross‐sectional study was conducted among (7‐18 years) with secondary tertiary care. Children were screened electronic questionnaires regarding respiratory allergic symptoms. Asthma‐specific assessed using Pediatric Asthma Quality Life Questionnaire PAQLQ (score range 1‐7)...
BackgroundThe diagnostic value of peanut components is extensively studied in children, but to a lesser extent adults with suspected allergy. The use daily practice may reduce the need for double-blind placebo-controlled food challenges (DBPCFCs); however, validation studies are currently lacking.ObjectiveTo evaluate (combined) and validate previously found Ara h 2 cutoff level 100% positive predictive (PPV) allergy.MethodsAdults who underwent DBPCFC were included: 84 patients from previous...