A5008341820- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Genomics and Rare Diseases
- Carbohydrate Chemistry and Synthesis
- Eosinophilic Esophagitis
- Glycogen Storage Diseases and Myoclonus
- Studies on Chitinases and Chitosanases
- Cancer Genomics and Diagnostics
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Ethics in Clinical Research
- Dermatology and Skin Diseases
- Occupational exposure and asthma
Amsterdam Neuroscience
2024
Amsterdam University Medical Centers
2020-2024
University of Amsterdam
2017-2024
Vrije Universiteit Amsterdam
2024
Amsterdam UMC Location University of Amsterdam
2015-2018
Component-resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention been given to combining them with clinical factors in predicting severity.To analyze sensitization patterns, patient characteristics history, develop models improve predictive accuracy.Patients reporting allergy (n = 423) from 12 European cities were tested for allergens. Symptoms (reported during Double-blind placebo-controlled...
The heterogeneity and lack of validation existing severity scores for food allergic reactions limit standardization case management research advances. We aimed to develop validate a score reactions.Following multidisciplinary experts consensus, it was decided allergy (FASS) with ordinal (oFASS) numerical (nFASS) formats. oFASS 3 5 grades were generated through expert nFASS by mathematical modeling. Evaluation performed in the EuroPrevall outpatient clinic cohort (8232 reactions) logistic...
Summary Background IgG 4 antibodies have been suggested to play a protective role in the translation of peanut sensitization into allergy. Whether they added value as diagnostic read‐out has not yet reported. Objective To evaluate whether (a) peanut‐specific IgG, and/or IgA are associated with tolerance less severe reactions and (b) can improve IgE‐based tests. Methods Sera 137 patients challenge‐proven allergy 25 subjects that tolerated peanut, both known IgE profiles extract five...
BackgroundWalnut allergy is common across the globe, but data on involvement of individual walnut components are scarce.ObjectivesTo identify geographical differences in component sensitization Europe, explore cosensitization and cross-reactivity, assess associations clinical serological determinants with severity allergy.MethodsAs part EuroPrevall outpatient surveys 12 European cities, standardized evaluation was conducted 531 individuals reporting symptoms to walnut, all known assessed 202...
Progress in genetic diagnosis and orphan drug legislation has opened doors to new therapies rare neurogenetic diseases (RNDs). Innovative such as gene therapy can improve patients' quality of life but come with academic, regulatory, financial challenges. Registries play a pivotal role generating evidence tackle these, their development requires multidisciplinary knowledge expertise. This study aims develop practical framework for creating implementing patient registries addressing common...
Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA). Objective: To gain insight into the clinical profile of subjects mild-to-moderate and severe PA, investigate individual collective predictive accuracy background IgE to extract components for PA severity. Methods: Data on demographics, patient history sensitization at component level 393 probable (symptoms ≤ 2 h + sensitization) from 12 EuroPrevall centers were analyzed. Univariable...
This study describes the influence of sex and disease phenotype on occurrence cardiac events in Fabry (FD).Cardiac from birth to last visit (median age 50 years) were recorded for 213 patients with FD. Patients categorised as follows : men classical FD (n=57), non-classical (n=26), women (n=98) (n=32), based presence symptoms, family history (men women), biomarkers residual enzyme activity (men). Event rates per 1000 patient-years after 15 years median event-free survival (EVS) presented....
Background: Fabry disease (FD) is an X-linked, lysosomal storage disorder leading to severe cardiomyopathy in a significant proportion of patients. To identify ECG markers that reflect early cardiac involvement and progression, we conducted long term retrospective study large cohort FD Methods: A total 1995 ECGs from 133 patients with classical (64% females, 80% treated enzyme replacement therapy), spanning 20 years follow-up, were compared 3893 apparently healthy individuals. Generalized...
Compared to Europe, little is known about sensitization food and inhalant sources in Russia China. To explore profiles of school-aged children urban rural settings from (Western Siberia) South-Eastern In the EuroPrevall-INCO survey, primary school (7-10 years) randomly selected schools China (Hong Kong [urban/n=401], Guangzhou [urban/n=402], Shaoguan [rural/n=349]) (Tomsk [urban&rural/n=1230]) were first screened by a short questionnaire for self-reported allergy. Subsequently, cases sampled...