Ekaterina Potapova
A5068769038- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Business Process Modeling and Analysis
- Contact Dermatitis and Allergies
- Behavioral Health and Interventions
- Semantic Web and Ontologies
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory and Cough-Related Research
- Traumatic Brain Injury Research
- Service-Oriented Architecture and Web Services
- Mobile Health and mHealth Applications
- Respiratory viral infections research
- Congenital Ear and Nasal Anomalies
- Immune Response and Inflammation
- Advanced Chemical Sensor Technologies
- Polydiacetylene-based materials and applications
- Cerebrospinal fluid and hydrocephalus
- Social Media in Health Education
- Meningioma and schwannoma management
- Information Technology Governance and Strategy
- ERP Systems Implementation and Impact
- Adipokines, Inflammation, and Metabolic Diseases
- Inhalation and Respiratory Drug Delivery
Humboldt-Universität zu Berlin
2021-2024
Charité - Universitätsmedizin Berlin
2018-2024
Freie Universität Berlin
2021-2024
Sunnybrook Health Science Centre
2016-2017
Health Sciences Centre
2016-2017
University of Lisbon
2016
National Research University Higher School of Economics
2009-2013
Abstract Since the discovery of immunoglobulin E (IgE) as a mediator allergic diseases in 1967, our knowledge about immunological mechanisms IgE‐mediated allergies has remarkably increased. In addition to understanding immune response and clinical symptoms, allergy diagnosis management depend strongly on precise identification elicitors reaction. past four decades, innovations bioscience technology have facilitated production well‐defined, highly pure molecules for component‐resolved (CRD),...
Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern countries with standardized approach.
Background Complete diagnosis and therapy of seasonal allergic rhinoconjunctivitis require evidence that exposure to the sensitizing pollen triggers symptoms. Electronic clinical diaries, by recording disease severity scores exposure, can demonstrate this association. However, patients who spontaneously download an e-diary app show very low adherence their recording. Objective The objective our study was assess with rhinitis symptom via explicitly prescribed allergist within a blended care...
Abstract Background IgE antibodies to cross‐reactive carbohydrate determinants (CCD) are usually clinically irrelevant but they can be a cause of false positive outcomes allergen‐specific tests in vitro. Their prevalence and levels have been so far cross‐sectionally examined among adult allergic patients much less is known about their origins relevance childhood. Methods We CCD with cross‐sectional approach 1263 Italian pollen children (Panallergen Paediatrics, PAN‐PED), as well longitudinal...
Cyclophilins are ubiquitous panallergens whose epidemiologic, diagnostic, and clinical relevance is largely unknown sensitization rarely examined in routine allergy practice.
Summary Background The identification of the primary sensitizing pollen is difficult in Southern European patients with Seasonal Allergic Rhinitis (SAR) if sensitized to various sources overlapping seasonality. A more precise diagnosis obtained by IgE assays allergen molecules, currently available as singleplex or microarrays. Objectives To test analytical performance a multi‐parameter immunoblot molecular “Pollen Test” specifically designed antibodies extracts and molecules clinically...
Abstract Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This especially relevant in geographic areas with broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate similarities differences PFAS nine European centers identify associated characteristics unique markers PFAS. Methods As part the @IT.2020 Multicenter Study, 815 patients seasonal allergic...
Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and phenotypes have been thoroughly examined several cross-sectional studies. By contrast, only few studies evolution patient cohorts. We investigated predictive biomarkers of large cohort children with SAR.During 2015-2017 (follow-up), we re-examined 401 patients from those enrolled 2009-2011 (baseline) by the "Panallergens Pediatrics" study, multicenter...
BackgroundHouse dust mite (HDM) allergens are major elicitors of allergic reactions worldwide.ObjectiveIdentification, characterization, and evaluation diagnostic utility a new important HDM allergen was performed.MethodsA cDNA coding for Dermatophagoides pteronyssinus (Dp) allergen, Der p 37, isolated from Dp expression library with patients' IgE antibodies. Recombinant 37 (rDer 37) expressed in Escherichia coli purified, then characterized by mass spectrometry, circular dichroism,...
Molecular antibody reactivity profiles have not yet been studied in depth patients treated by sublingual house dust mite (HDM) tablet immunotherapy. Humoral immune responses to a large panel of HDM allergens were using allergen microarray technology subset clinically defined high and low responder from double-blind placebo-controlled allergen-specific immunotherapy (AIT) trial 300 IR tablets.Serum levels IgE, IgG IgG4 13 Dermatophagoides pteronyssinus molecules measured at baseline after...
The adequate definition of pollen seasons is essential to facilitate a correct diagnosis, treatment choice, and outcome assessment in patients with seasonal allergic rhinitis. A position paper by the European Academy Allergy Clinical Immunology (EAACI) proposed season definitions for Northern Middle Europe.To test EAACI six Mediterranean cities seven taxa.As part @IT.2020 multi-center study, counts Poaceae, Oleaceae, Fagales, Cupressaceae, Urticaceae (Parietaria spp.), Compositae (Ambrosia...
Abstract Background The Dermatophagoides pteronyssinus molecule Der p 23 is a major allergen whose clinical relevance has been shown in cross‐sectional studies. We longitudinally analysed the trajectory of 23‐specific IgE antibody (sIgE) levels throughout childhood and youth, their early‐life determinants for allergic rhinitis asthma. Methods obtained sera data 191 participants German Multicentre Allergy Study, prospective birth cohort. Serum samples from to 20 years age with sIgE reactivity...
Abstract Mobile health is the “medical and public practice supported by mobile devices, such as phones, patient monitoring personal digital assistants, other wireless devices.” For example, apps (such MASK‐Air, Allergy.Monitor, Pollen, others) have proven useful in management of patients with allergic rhinitis. These can be used context broader clinical decision support systems (CDSS) for enhancing allergy‐related decisions actions pertinent, organized knowledge information to improve...
The measurement of specific IgE to allergenic extracts and molecules in patients with allergic rhinitis (AR) is crucial for a precise diagnosis further immunotherapy. Companies providing vitro diagnostic methods allergology continuously strive the optimization modernization such methods. A new generation automated allergy tests based on chemiluminescence detection paramagnetic microparticles now available, possible advantages sample volume, cost-effectiveness avoidance sample-related...
There is growing interest both in testing IgE nasal secretions (NS) and molecular diagnosis of seasonal allergic rhinitis (SAR). Yet, the reliability detection with newest assays has never been assessed a large cohort pollen patients.To investigate microarray technology compare repertoires specific (sIgE) antibodies NS sera population children adults SAR.Nasal were collected an absorbent device (Merocel 2000® , Medtronic) minimal dilution procedure from 90 71 SAR. Total (tIgE) (ImmunoCAP,...
Abstract Background Patient‐generated symptom and medication scores are essential for diagnostic therapeutic decisions in seasonal allergic rhinitis (SAR). Previous studies have shown solid consistencies between different at population level real‐life data trials. For clinicians, the evaluation of individual quality over time is to decide whether rely on these clinical decision‐making. Objective To analyze consistency (SS) (SMSs) two study cohorts with characteristics explore patient...
In vitro immunoglobulin E (IgE) tests can be better standardized if based on molecules rather than extracts. However, singleplex screening for respiratory or food allergies are still extracts only.To validate a novel IgE test allergies, mix of major allergenic Der p 1, 2, Fel d Can f 3, 5, Bet v Phl and Art 1 (Molecular SX01, NOVEOS, HYCOR, USA), requiring only four microliters (μl) serum.We examined six subsets sera from participants the German Multicenter Allergy Study (MAS) birth cohort...
Abstract Objectives Detection of allergen-specific immunoglobulin E (sIgE) is important for the diagnosis allergy. IgE sensitization commonly demonstrated in vivo by skin prick testing (SPT), or vitro utilizing automated systems. Recently, HYCOR ® Biomedical launched its new system allergen sIgE called NOVEOS™ Immunoanalyzer. This study aims to evaluate analytical performance NOVEOS a bi-center at Philipps-University Marburg (Site-1) and Charité Medical University Berlin (Site-2),...
Summary The prevalence of immunoglobulin E (IgE)-mediated allergic diseases is currently experiencing an epidemic trend characterized by increase in both the number affected individuals and proportion patients with multiple sensitizations. majority these sensitizations are attributed to IgE reactions genuine allergenic proteins from unrelated species. However, there a growing becoming sensitized highly cross-reactive molecules, such as profilins, polcalcins, lipocalins, serum albumins,...