A5060996219- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Eosinophilic Esophagitis
- Contact Dermatitis and Allergies
- Parasite Biology and Host Interactions
- Urticaria and Related Conditions
- Mast cells and histamine
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Child Nutrition and Feeding Issues
- Occupational exposure and asthma
- Pediatric health and respiratory diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Olfactory and Sensory Function Studies
- Eosinophilic Disorders and Syndromes
- Autoimmune Bullous Skin Diseases
- Galectins and Cancer Biology
- Medical Imaging and Pathology Studies
- Autoimmune and Inflammatory Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Pneumocystis jirovecii pneumonia detection and treatment
- Mobile Health and mHealth Applications
Hospital General Universitario Gregorio Marañón
2014-2025
Centre for Biomedical Network Research on Rare Diseases
2010-2025
National Jewish Health
2022
University of Colorado Denver
2022
Rady Children's Hospital-San Diego
2022
Instituto de Salud Carlos III
2017-2021
Instituto de Investigaciones Biomédicas Sols-Morreale
2021
Universidad Autónoma de Madrid
2021
Consejo Superior de Investigaciones Científicas
2021
Hospital do Desterro
2019
The randomized, controlled PALISADE trial demonstrated the benefit of daily oral immunotherapy with Peanut (Arachis Hypogaea) allergen powder-dnfp (PTAH, formerly AR101) in peanut-allergic children and adolescents.ARC004, open-label follow-on study to PALISADE, used 5 dosing cohorts explore PTAH treatment beyond 1 year alternative regimens individuals.Active arm (PTAH-continuing) participants who tolerated 300-mg peanut protein at exit double-blind placebo-controlled food challenge placebo...
Abstract We previously demonstrated that treatment of acute asthmatic rats with gene therapy using plasmid-encoding Galectin-3 (Gal-3) resulted in an improvement cellular and functional respiratory parameters. The next question we wanted to clarify was if a chronic situation where the treated animal continues inhale Ag, does this procedure prevent chronicity remodeling? Chronic inflammation induced by intranasal administration OVA over period 12 wk. In group, Gal-3 introduced instillation 50...
Insulin-like growth factor-I (IGF-I) belongs to the family of insulin-related peptides that fulfils a key role during late development nervous system. Human IGF1 mutations cause profound deafness, poor and mental retardation. Accordingly, Igf1(-/-) null mice are dwarfs have low survival rates, cochlear alterations severe sensorineural deafness. Presbycusis (age-related hearing loss) is common disorder associated with aging causes social cognitive problems. Aging also decrease in circulating...
Suppresors of cytokine signaling (SOCS) proteins regulate responses and control immune balance. Several studies have confirmed that SOCS3 is increased in asthmatic patients, expression correlated with disease severity. The objective this study was to evaluate if delivering short interfering RNA (siRNA) intranasally lungs could be a good therapeutic approach an asthma chronic mouse model. Our results showed intranasal treatment SOCS3-siRNA led improvement the eosinophil count normalization...
<b><i>Background:</i></b> Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity usually due to cow’s milk or soy. Among the solid foods, rice one of most causative foods worldwide, but it varies depending on geographic area. In Mediterranean countries, fish important triggers FPIES. There not specific biological marker for disease that allows us confirm diagnosis predict when tolerance offending has been...
Table 1.Referral questionnaire for controlled administration of mRNA vaccines against COVID-19 in the Allergy DepartmentHave you ever had a serious allergic reaction (anaphylaxis): sudden onset shortness breath, feeling difficulty swallowing, dizziness, or loss consciousness, swelling face, lips, uvula, with of: food, medicine, latex, previous vaccinations, wasp/bee sting no known cause?Have been diagnosed mastocytosis mast cell activation syndrome?Have allergy to PEG = polyethylene glycol...
Abstract Immunotherapy (IT) by injection more readily induces clinical tolerance to stinging insects than respiratory allergens. However, while systemic immunization adaptive responses systemically, the induction of mucosal immunity generally requires local Ag exposure. Taken together, these observations suggest that poor success rate IT for asthma could be a consequence inadequate immune modulation in airways. In support this position, investigations presented report demonstrate allergen...
Diagnostic methods for the study of allergic reactions to Anisakis simplex (A.s.) based on whole-body extracts larva are clearly insufficient.To allergenicity proteins secreted by parasite. Comparison with somatic antigens and determination their clinical importance in patients were also addressed.An excretory/secretory (E/S) extract was produced culturing third-stage A.s. larvae. It used perform immediate skin tests determine specific IgE 10 diagnosed allergy Both compared results obtained...
The presence of IL-1 mRNA in eosinophils from mice infected with larvae the parasite Mesocestoides corti was investigated by situ hybridization technique. S35 labeled cDNA probe for alpha IL-1, hybridized murine and macrophages. After 6 h LPS stimulation were able to express their cytoplasm. This expression highly increased addition indomethacine. macrophages higher than LPS-stimulated cells. difference statistically significant, p less 0.001. To test if may produce release culture medium,...
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity usually due to cow's milk or soy. Recent researches show that fish 1 of the most important triggers FPIES in Mediterranean countries. Due risk multiple-food FPIES, avoiding foods same category often occur together may be reasonable. The aim this study was evaluate evolution and follow-up related over period 20 years. We describe clinical features our population, discuss different...
The European Medicines Agency (EMA) promotes regulatory science and innovation by providing state-of-the-art recommendations to medicines developers. Guidelines developed EMA's committees working parties support evidence generation encourage appropriate methodology, enabling the evaluation of medicinal products. newly Guideline on allergen products development for immunotherapy allergy diagnosis in moderate-to-low-sized study populations provides scientific guidance allergies. guideline is...
Food allergy markedly impairs quality of life, and avoiding the offending food requires extensive patient education. Social media have been proven a useful source information for other chronic conditions. Our aim was to describe how pediatric patients with their families are using social media.We performed cross-sectional study in unit tertiary hospital. Patients were questioned about disease use media. The survey completed by themselves case those aged over 13 years parents or guardians...
Insulin-like growth factor 1 (IGF-1) deficiency is an ultrarare syndromic human sensorineural deafness. Accordingly, IGF-1 essential for the postnatal maturation of cochlea and correct wiring hearing in mice. Less severe decreases levels have been associated with other loss rare genetic syndromes, as well age-related (ARHL). However, underlying mechanisms linking haploinsufficiency auditory pathology ARHL not studied. Igf1-heterozygous mice express less Igf1 transcription 40% lower serum...