A5011231666- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Muscle Physiology and Disorders
- Cardiovascular and exercise physiology
- Nutrition and Health in Aging
- Exercise and Physiological Responses
- Heart Rate Variability and Autonomic Control
- Advanced Chemical Sensor Technologies
- Dialysis and Renal Disease Management
- Spectroscopy and Laser Applications
- High Altitude and Hypoxia
- Cerebral Palsy and Movement Disorders
- Gas Sensing Nanomaterials and Sensors
- Obstructive Sleep Apnea Research
- Stroke Rehabilitation and Recovery
- Asthma and respiratory diseases
- Angiogenesis and VEGF in Cancer
- Cardiovascular Function and Risk Factors
- Frailty in Older Adults
- Cardiovascular and Diving-Related Complications
- Delphi Technique in Research
- Muscle activation and electromyography studies
- Lymphatic System and Diseases
- Autophagy in Disease and Therapy
- Hydrogen's biological and therapeutic effects
Physiologie et Médecine Expérimentale du Coeur et des Muscles
2015-2024
Université de Montpellier
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Inserm
2015-2024
Centre Hospitalier Universitaire de Montpellier
2015-2024
Hôpital Arnaud de Villeneuve
2024
Czech Academy of Sciences, Institute of Physiology
2023
Hôpital Européen Georges-Pompidou
2022
Hôpital Lapeyronie
2016
Gefluc Languedoc Roussillon
2014
The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration develop multi-sectoral care pathways chronic respiratory diseases in European countries and regions.AIRWAYS-ICPs has strategic relevance the Union Health Strategy will add value existing public health knowledge by: 1) proposing common framework diseases, which facilitate comparability trans-national initiatives; 2) informing cost-effective policy development, strengthening particular...
Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD), particularly after exacerbations. We thus asked whether neuromuscular electrostimulation (NMES) might be directly useful following an acute exacerbation and if such therapy decreases muscular oxidative stress and/or alters muscle fibre distribution. A pilot randomised controlled study of NMES lasting 6 weeks was carried out 15 in-patients (n=9 NMES; n=6 sham) COPD exacerbation. Stimulation delivered to the...
Oxidative stress is thought to be one of the most important mechanisms implicated in muscle wasting chronic obstructive pulmonary disease (COPD) patients, but its role has never been demonstrated. We therefore assessed effects both pro-oxidant and antioxidant treatments on oxidative levels atrophic signaling pathway cultured COPD myotubes. Treatment myotubes with molecule H2O2 resulted increased ROS production (P = 0.002) protein carbonylation 0.050), association a more pronounced atrophy...
The impaired skeletal muscle of chronic obstructive pulmonary disease (COPD) patients reduces exercise capacity. Similar to the oxidative fibres, angio-adaptation training may be blunted in these patients, as other conditions. We therefore compared functional responses and angio-adaptations after COPD sedentary healthy subjects (SHS). 24 (forced expiratory volume 1 s 45.6±17.5% predicted) 23 SHS (<150 min·week −1 moderate-to-vigorous exercise) completed a 6-week rehabilitation programme...
Abstract The mechanisms leading to skeletal limb muscle dysfunction in chronic obstructive pulmonary disease ( COPD ) have not been fully elucidated. Exhausted regenerative capacity of satellite cells has evocated, but the proliferate and differentiate properly remains unknown. Our objectives were compare characteristics derived from patients healthy individuals, terms proliferative differentiation capacities, morphological phenotype atrophy/hypertrophy signalling, oxidative stress status....
Abstract Background Pulmonary rehabilitation (PR) improves exercise capacity, health-related quality of life (HRQoL) and dyspnea in chronic obstructive pulmonary disease (COPD) patients. Maintenance programs can sustain the benefits for 12 to 24 months. Yet, long-term effects (> months) pragmatic maintenance real-life settings remain unknown. This prospective cohort study assessed yearly evolution outcomes [6-min walking distance (6MWD), HRQoL, dyspnea] a supervised self-help PR program...
Background . Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD) is not fully reversed by exercise training. Antioxidants are critical for homeostasis and adaptation to However, COPD experience antioxidant deficits that worsen after training might impact their response Nutritional supplementation combination rehabilitation (PR) would further improve function, oxidative stress, PR outcomes patients. Methods Sixty-four admitted inpatient were randomized...
Background Muscle weakness is associated with increased mortality risk in chronic haemodialysis (CHD) patients. Protein energy wasting (PEW) and low physical activity could impair muscle quality contribute to beyond these Aim of this study was assess clinical biological parameters involved the reduction strength CHD Methods One hundred twenty-three patients (80 males, 43 females; 68,8 [57.9–78.8] y.o.) were included study. Maximal voluntary force (MVF) quadriceps assessed using a...
Sarcopaenia, defined as a decline in both muscle mass and function, has been recognized major determinant of poor outcome haemodialysis (HD) patients. It is generally assumed that sarcopaenia driven by atrophy related to protein-energy wasting. However, dynapaenia, weakness without atrophy, characterized different disease phenotype from sarcopaenia. The aim this study was compare the characteristics prognosis sarcopaenic dynapaenic patients among prospective cohort chronic HD (CHD)...
The proteolytic autophagy pathway is enhanced in the lower limb muscles of patients with chronic obstructive pulmonary disease (COPD). Reactive oxygen species (ROS) have been shown to regulate skeletal muscles, but role oxidative stress muscle COPD unknown. We used cultured myoblasts and myotubes from quadriceps eight healthy subjects twelve (FEV1% predicted: 102.0% 32.0%, respectively; p < 0.0001). compared autophagosome formation, expression markers, autophagic flux COPD, we evaluated...
Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, literature reveals that systemic OS markers show great heterogeneity, which may hinder prescription effective antioxidant supplementation. This study therefore aimed to identify imbalance patients, relative validated normal reference values, investigate possibility profiles. We measured enzymatic/nonenzymatic lipid peroxidation (LP) levels 54 stable patients referred for...
This work investigates the behavior of commercial and custom Quartz tuning forkss (QTF) under humidity variations. The QTFs were placed inside a chamber parameters studied with setup to record resonance frequency quality factor by tracking. variations these that led 1% theoretical error on Enhanced Photoacoustic Spectroscopy (QEPAS) signal defined. At controlled level humidity, present similar results. Therefore, appear be very good candidates for QEPAS as they are also affordable small....
Chronic obstructive pulmonary disease (COPD) is a clinical entity of increasing significance. COPD involves abnormalities the airways and, in emphysema, parenchymal destruction. Cardiovascular has emerged as significant comorbidity to COPD. Heart failure with preserved ejection fraction (HFpEF) appears be particularly associated COPD-emphysema. Traditional treatments have shown limited efficacy improving COPD-associated HFpEF. This lack therapeutic highlights need identify potential...
Peripheral muscle dysfunction, associated with reductions in fiber cross-sectional area (CSA) and type I fibers, is a key outcome chronic obstructive pulmonary disease (COPD). However, COPD peripheral function structure show great heterogeneity, overlapping those sedentary healthy subjects (SHS). While discrepancies the link between phenotype remain unexplained, we tested whether CSA were attributes of different phenotypes disease, using unsupervised clustering method post hoc validation....
Age and comorbidity-related sarcopenia represent a main cause of muscle dysfunction in patients on long-term hemodialysis. However, recent findings suggest abnormalities that are not associated with sarcopenia. The aim this study was to isolate functional cellular independently other major confounding factors, including malnutrition, age, comorbidity, or sedentary lifestyle, which common maintenance To overcome these alterations skeletal were analyzed highly selected hemodialysis undergoing...