A5034640453- Health, Medicine and Society
- Diabetes Management and Research
- Diet and metabolism studies
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health in Aging
- Healthcare Systems and Practices
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Lipoproteins and Cardiovascular Health
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Diabetic Foot Ulcer Assessment and Management
- Pharmaceutical Practices and Patient Outcomes
- Obstructive Sleep Apnea Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Education
- Cardiovascular Function and Risk Factors
- Protein Kinase Regulation and GTPase Signaling
- Pharmacology and Obesity Treatment
- Muscle metabolism and nutrition
- Diet, Metabolism, and Disease
- Cardiac Imaging and Diagnostics
- Body Composition Measurement Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Centre Hospitalier Universitaire de Montpellier
2016-2025
Inserm
2016-2025
Université de Montpellier
2016-2025
Institut Universitaire de Recherche Clinique
2021-2024
Institut Desbrest d'Epidémiologie et de Santé Publique
2024
Hôpital Lapeyronie
2008-2023
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2023
Physiologie et Médecine Expérimentale du Coeur et des Muscles
2012-2021
Centre National de la Recherche Scientifique
2015-2021
Saint Joseph University
2021
We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders cancers, which together are the predominant problem of 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care multi-scale, multi-modal multi-level systems approaches tackle NCDs as a common group diseases. Rather than studying each...
OBJECTIVE To evaluate the relative value of plasma glucose (PG) at different time points in assessing control type 2 diabetic patients. RESEARCH DESIGN AND METHODS Glycemic profiles, i.e., PG prebreakfast (8:00 A.M.), prelunch (11:00 postlunch (2:00 P.M.), and extended (5:00 P.M.) times over same day, were obtained 66 patients on an ambulatory basis. The compared with a measurement HbA1c made reference laboratory. RESULTS Extended was lower than (104 ± 21 vs. 133 35 mg/dl, P < 0.02)...
We presently studied (a) insulin effects on protein kinase C (PKC) and (b) of transfection-induced, stable expression PKC isoforms glucose transport in 3T3/L1 cells. In both fibroblasts adipocytes, provoked increases membrane enzyme activity levels PKC-α PKC-β. However, insulin-induced were apparent non-down-regulated adipocytes that down-regulated by overnight treatment with 5 μM phorbol ester, which largely depletes PKC-α, PKC-β, PKC-ϵ, but not PKC-η. Moreover, the immunoprecipitable...
The long-term outcome and functional status of subjects hospitalized for diabetic foot ulcers have been poorly studied thus are the topics this study.Ninety-four consecutive between January 1998 December 2000 were prospectively followed mean +/- SD 79.5 13.3 months. We calculated rates primary healing, new ulcers, amputations, mortality, disability evaluated global therapeutic success (GTS) care management as defined by association healing without recurrence or at end follow-up.Follow-up was...
To assess the clinical efficacy of nutritional amounts grape polyphenols (PPs) in counteracting metabolic alterations high-fructose diet, including oxidative stress and insulin resistance (IR), healthy volunteers with high risk.Thirty-eight overweight/obese first-degree relatives type 2 diabetic patients (18 men 20 women) were randomized a double-blind controlled trial between PP (2 g/day) placebo (PCB) group. Subjects investigated at baseline after 8 9 weeks supplementation, last 6 days...
We examined the possibility that protein kinase C (PKC) is chronically activated and may contribute to impaired glycogen synthesis insulin resistance in soleus muscles of hyperinsulinemic type II diabetic Goto-Kakizaki (GK) rats. Relative nondiabetic controls, PKC enzyme activity levels immunoreactive PKC-α, β, є, delta were increased membrane fractions decreased cytosolic GK muscles. In addition, PKC-θ both cytosol fractios, whereas PKC-ζ not changed either fraction These increases (α, δ)...
To investigate whether atherogenic dyslipidemia, a dyslipidemic profile combining elevated triglycerides and low high-density lipoprotein (HDL) cholesterol, is predictive of risk silent myocardial ischemia (SMI) or angiographic coronary artery disease (CAD) in asymptomatic patients with type 2 diabetes. Cohort study 1080 diabetes normal resting electrocardiogram, at least one additional cardiovascular factor density (LDL) cholesterol <3.35 mmol/L. Patients initially underwent screening for...
Osteoprotegerin (OPG) is an inhibitor of osteoclastogenesis, which has been recently involved in atherosclerosis. The relationship between coronary atherosclerosis and OPG never studied asymptomatic type 2 diabetic patients.This a nested case-control study; 162 patients were evaluated for silent myocardial ischemia using stress perfusion imaging; 50 with positive results, 37 underwent angiography, 20 whom showed significant artery disease (CAD group). Of 112 without ischemia, subjects...
This retrospective cohort study aimed to assess the effectiveness of semaglutide 2.4 mg in patients with severe obesity (BMI ≥ 40 kg/m
To determine whether, over daytime, one or several hyperglycemic excursions exist that can be general failures in the glycemic control of patients with type 2 diabetes.In 200 non-insulin-using diabetes, diurnal plasma glucose and insulin profiles were studied. Plasma concentrations measured after an overnight fast (at 8:00 A.M. immediately before breakfast), during postprandial period 11:00 2:00 P.M.), postabsorptive 5:00 P.M., extended postlunch time).In population considered as a whole,...
We sought to evaluate osteoprotegerin, an inhibitor of osteoclastogenesis involved in atherosclerosis, and other novel risk factors as predictive markers silent myocardial ischemia (SMI).A total 465 consecutive diabetic patients with more than one additional factor were evaluated for SMI using stress perfusion imaging (MPI). studied the association (positive electrocardiogram and/or abnormal MPI) (lipoprotein[a], homocysteine, adiponectin, C-reactive protein, fibrinogen), conventional...
Objective First, the aim of study was to assess prevalence, characteristics, and severity unintended medication discrepancies (UMDs) errors (MEs) at admission discharge hospitalization. Second, identify clinical hospitalization factors associated with risk UMDs as well characteristics reconciliation process detection. Methods This prospective observational included all adult patients admitted from 2013 2015 in Endocrinology-Diabetology-Nutrition Department Montpellier Hospital, France....
We questioned whether phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase C (PKC) function as interrelated signalling mechanisms during insulin action in rat adipocytes. Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), this activation was accompanied by increases diacylglycerol translocative of PKC-α PKC-β the plasma membrane. Wortmannin, an apparently specific PI inhibitor, inhibited insulin-stimulated, D-dependent PC hydrolysis subsequent...
Exercise is recognized as a part of the management obesity and diabetes. Various protocols exercise are proposed for obesity, diabetes, other metabolic diseases. One strategies by several authors low intensity endurance training targeted at level maximal oxidation. Large series using this technique lacking. Addressing issue, we performed meta-analysis studies on anthropometric measurements. From database 433 articles, 15 were selected, including 279 subjects with 6 different populations....