A5075827833- Blood Coagulation and Thrombosis Mechanisms
- Pregnancy and preeclampsia studies
- Venous Thromboembolism Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Maternal and fetal healthcare
- Platelet Disorders and Treatments
- Cardiovascular Issues in Pregnancy
- Hemophilia Treatment and Research
- Reproductive System and Pregnancy
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal Diseases and Glomerulopathies
- Blood disorders and treatments
- Blood properties and coagulation
- Birth, Development, and Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Folate and B Vitamins Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Complement system in diseases
- COVID-19 Impact on Reproduction
- Reproductive Biology and Fertility
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
Université de Nîmes
2016-2025
Université de Montpellier
2016-2025
Inserm
2021-2025
Sechenov University
2010-2025
Centre Hospitalier Universitaire de Nîmes
2015-2024
Institut Universitaire de Recherche Clinique
2000-2024
French Clinical Research Infrastructure Network
2023-2024
Institut Desbrest d'Epidémiologie et de Santé Publique
2021-2023
Universitat Rovira i Virgili
2023
Government of Catalonia
2023
Abstract Objective To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort patients to define patterns disease expression. Methods The serologic features APS (Sapporo preliminary criteria) 1,000 from 13 European countries were analyzed using computerized database. Results consisted 820 female (82.0%) 180 male (18.0%) with mean ± SD age 42 14 years at study entry. “Primary” was present 53.1% patients; associated systemic lupus erythematosus...
To assess the prevalence of main causes morbi-mortality in antiphospholipid syndrome (APS) during a 10-year-follow-up period and to compare frequency early manifestations with those that appeared later.In 1999, we started an observational study 1000 APS patients from 13 European countries. All had medical histories documented when entered into were followed prospectively ensuing 10 years.53.1% primary APS, 36.2% associated systemic lupus erythematosus 10.7% other diseases. Thrombotic events...
To identify the main causes of morbidity and mortality in patients with antiphospholipid syndrome (APS) during a 5-year period to determine clinical immunological parameters prognostic significance.The features cohort 1000 APS from 13 European countries who had been followed up 1999 2004 were analysed.200 (20%) developed APS-related manifestations study period. Recurrent thrombotic events appeared 166 (16.6%) most common strokes (2.4% total cohort), transient ischaemic attacks (2.3%), deep...
To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. This international multidisciplinary initiative included 4 phases: 1) Phase I, generation surveys literature review; 2) II, reduction modified Delphi nominal group technique exercises; 3) III, definition, further guidance real-world patient scenarios, weighting via consensus-based...
<h3>Objective</h3> To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. <h3>Methods</h3> This international multidisciplinary initiative included four phases: (1) Phase I, generation surveys literature review; (2) II, reduction modified Delphi nominal group technique exercises; (3) III, definition, further guidance real-world patient...
Unlike classic APS, CAPS causes multiple microthrombosis due to an increased inflammatory response, known as a “thrombotic storm”. typically develops after infection, trauma, or surgery and begins with the following symptoms: fever, thrombocytopenia, muscle weakness, visual cognitive disturbances, abdominal pain, renal failure, disseminated intravascular coagulation. Although presence of antiphospholipid antibodies in blood is one diagnostic criteria, level these can fluctuate significantly,...
Summary There is a lack of consensus on the value detecting and treating symptomatic isolated distal deep-vein thrombosis (DVT) lower limbs. In our study, we compared risk factors outcomes in patients with DVT those proximal DVT. We analysed data objectively confirmed enrolled national (France), multicenter, prospective OPTIMEV study.This sub-study were recurrent venous thromboembolism, major bleeding death at three months. Among 6141 suspicion included between November 2004 January 2006,...
Background: NETosis occurs in the context of infection or inflammation and results expulsion decondensed DNA filaments called NETs (Neutrophil Extracellular Traps) into extracellular environment. activates coagulation contributes to thrombotic risk inflammatory diseases. To date, two mechanisms have been identified: suicidal NETosis, which neutrophils die after expelling filaments; vital appears without altering membrane. Human pregnancy is associated with a mild pro-inflammatory state,...
Cancer patients are at risk of developing arterial and venous thrombosis during chemotherapy (CT) after its cessation. A prothrombotic may arise via pathogenetic pathways such as activation external internal coagulation pathways, decreased anticoagulant levels, platelet activation, fibrinolysis blockade, etc. Chemotherapeutic agents exert direct cytotoxicity, well indirectly suppress cellular processes necessary for tumor cell proliferation. CT-related cytotoxicity act on both healthy body...
The article delves into the systemic inflammatory response syndrome (SIRS), thromboinflammation, and septic shock in fetuses neonates, providing a comprehensive examination of their pathophysiology, diagnostic criteria, clinical implications. It establishes SIRS as hyper-reaction to external stress, disrupting balance between inflammation adaptive mechanisms, driven by cytokines like TNF-α IL-1. fetal (FIRS), subset SIRS, is highlighted for its role adverse neonatal outcomes, including organ...
Aim : to carry out a comparative analysis of the pathogenesis, clinical manifestations, diagnostic criteria as well therapeutic strategies vaccine-induced thrombotic thrombocytopenia (VITТ) and heparin-induced (HIT), two rare but potentially life-threatening conditions associated with antibody-dependent platelet activation. Materials Methods . Current data on epidemiology, presentation, diagnosis, treatment VITТ HIT have been reviewed including an existing scoring systems, laboratory tests,...
Summary Background: Women with familial thrombophilia have an increased risk of still birth. We postulated that the presence asymptomatic factors for venous thrombosis might be a factor late foetal loss. Methods: performed case-control study on prevalence heritable thrombophilic defects, antiphospholipid-related markers and C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene patients at least one episode unexplained loss control women successful pregnancies. Partners cases...
To assess the role of insulin receptor, receptor substrate (IRS)-1, and IRS-2 genes in resistance, we explored genomic DNA women with polycystic ovary syndrome (PCOS) a variable degree (mean ± SE) resistance (homeostasis model assessment index for [HOMAIR] 3.2 0.6, n = 53; control subjects 1.56 0.34, 102) using direct sequencing. Whereas no novel mutations were found these genes, gene-dosage effects on fasting Gly972Arg IRS-1 variant 2-h plasma glucose Gly1057Asp variant. The was more...