A5071939353- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Polyomavirus and related diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cytomegalovirus and herpesvirus research
- Systemic Sclerosis and Related Diseases
- Complement system in diseases
- Organ Donation and Transplantation
- Parvovirus B19 Infection Studies
- Vasculitis and related conditions
- Renal cell carcinoma treatment
- Autoimmune Bullous Skin Diseases
- COVID-19 Clinical Research Studies
- Biomedical Research and Pathophysiology
- Pregnancy and preeclampsia studies
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Atherosclerosis and Cardiovascular Diseases
- Dialysis and Renal Disease Management
- Birth, Development, and Health
- Transplantation: Methods and Outcomes
Cornell University
2016-2025
Presbyterian Hospital
2011-2025
Weill Cornell Medicine
2016-2025
NewYork–Presbyterian Hospital
2013-2024
New York Hospital Queens
2013-2024
University Medical Center
2023
Hospital for Special Surgery
2022
RELX Group (United States)
2017-2020
International Society of Nephrology
2003-2020
Metabolism and Renal Physiology
2020
Although pathologic classifications exist for several renal diseases, including IgA nephropathy, focal segmental glomerulosclerosis, and lupus nephritis, a uniform classification diabetic nephropathy is lacking. Our aim, commissioned by the Research Committee of Renal Pathology Society, was to develop consensus combining type1 type 2 nephropathies. Such should discriminate lesions various degrees severity that would be easy use internationally in clinical practice. We divide into four...
Antibody-mediated rejection (AbAR) is increasingly recognized in the renal allograft population, and successful therapeutic regimens have been developed to prevent treat AbAR, enabling excellent outcomes even patients highly sensitized donor prior transplant. It has become critical develop standardized criteria for pathological diagnosis of AbAR. This article presents international consensus classification AbAR based on discussions held at Sixth Banff Conference Allograft Pathology 2001....
The 10th Banff Conference on Allograft Pathology was held in Banff, Canada from August 9 to 14, 2009. A total of 263 transplant clinicians, pathologists, surgeons, immunologists and researchers discussed several aspects solid organ transplants with a special focus antibody mediated graft injury. willingness the process adapt continuously response new research improve potential weaknesses, led implementation six working groups following areas: isolated v‐lesion, fibrosis scoring, glomerular...
The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation Vancouver, Canada, reviewed clinical impact updates C4d-negative antibody-mediated rejection (ABMR) from 2013 reports active Working Groups, relationships donor-specific antibody tests (anti-HLA and non-HLA) with transplant histopathology, questions molecular diagnostics. use transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement diagnosis classification requires...
The outcome of renal transplantation after an episode acute rejection is difficult to predict, even with allograft biopsy.We studied urine specimens from 36 subjects rejection, 18 chronic nephropathy, and 29 normal biopsy results. Levels messenger RNA (mRNA) for FOXP3, a specification functional factor regulatory T lymphocytes, mRNA CD25, CD3epsilon, perforin, 18S ribosomal (rRNA) were measured kinetic, quantitative polymerase-chain-reaction assay. We examined associations levels reversal,...
Ischemia causes AKI as a result of ATP depletion, and rapid recovery on reperfusion is important to minimize tissue damage. often delayed, however, because ischemia destroys the mitochondrial cristae membranes required for synthesis. The mitochondria-targeted compound SS-31 accelerates after reduces AKI, but its mechanism action remains unclear. Here, we used polarity-sensitive fluorescent analog demonstrate that binds with high affinity cardiolipin, an anionic phospholipid expressed inner...
Immune rejection of organ transplants is a life-threatening complication and exemplified by alterations in the expression protein-encoding genes. Because microRNAs (miRNAs) regulate genes implicated adaptive immunity, we investigated whether acute (AR) associated with miRNA within allografts profiles are diagnostic AR predict allograft function. Seven 33 renal biopsies (12 21 normal) were profiled using microfluidic cards containing 365 mature human miRNAs (training set), subset...
The burst of reactive oxygen species (ROS) during reperfusion ischemic tissues can trigger the opening mitochondrial permeability transition (MPT) pore, resulting in depolarization, decreased ATP synthesis, and increased ROS production. Rapid recovery upon is essential for survival tubular cells, inhibition oxidative damage limit inflammation. SS-31 a mitochondria-targeted tetrapeptide that scavenge inhibit MPT, suggesting it may protect against renal injury. Here, rat model...
Obesity is a major risk factor for the development of chronic kidney disease, even independent its association with hypertension, diabetes, and dyslipidemia. The primary pathologic finding obesity-related disease glomerulopathy, glomerular hypertrophy, mesangial matrix expansion, focal segmental glomerulosclerosis. Proposed mechanisms leading to renal pathology include abnormal lipid metabolism, lipotoxicity, inhibition AMP kinase, endoplasmic reticulum stress. Here we report dramatic...
Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification diagnosis of GN, with a major aim standardizing the kidney biopsy report GN. On basis etiology/pathogenesis, GN is classified into following five pathogenic types, each specific disease entities: immune-complex pauci-immune antiglomerular basement membrane monoclonal Ig C3 glomerulopathy. The pathogenesis-based forms report. To standardize report, consists...
To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. This international multidisciplinary initiative included 4 phases: 1) Phase I, generation surveys literature review; 2) II, reduction modified Delphi nominal group technique exercises; 3) III, definition, further guidance real-world patient scenarios, weighting via consensus-based...
<h3>Objective</h3> To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. <h3>Methods</h3> This international multidisciplinary initiative included four phases: (1) Phase I, generation surveys literature review; (2) II, reduction modified Delphi nominal group technique exercises; (3) III, definition, further guidance real-world patient...
<b><i>Background:</i></b> A novel coronavirus, SARS-CoV-2, was identified in Wuhan, China late 2019. This virus rapidly spread around the world causing disease ranging from minimal symptoms to severe pneumonia, which termed coronavirus (i.e., COVID). Postmortem examination is a valuable tool for studying pathobiology of this new infection. <b><i>Methods:</i></b> We report clinicopathologic findings 32 autopsy studies conducted on patients who...
Polyomavirus nephropathy (PVN) is a common viral infection of renal allografts, with biopsy-proven incidence approximately 5%. A generally accepted morphologic classification definitive PVN that groups histologic changes, reflects clinical presentation, and facilitates comparative outcome analyses lacking. Here, we report scheme for from the Banff Working Group on Nephropathy, comprising nine transplant centers in United States Europe. This study represents largest systematic analysis...
Increased expression of type I interferon (IFN) and a broad signature IFN-induced gene transcripts are observed in patients with systemic lupus erythematosus (SLE) other autoimmune diseases. To identify disease-relevant triggers the IFN pathway, this study sought to investigate whether endogenous virus-like genomic repeat elements, normally silent, expressed disease, these retroelements could activate an innate immune response induce IFN.Expression long interspersed nuclear element 1...
The innate immune system has been implicated in both AKI and CKD. Damaged mitochondria release danger molecules, such as reactive oxygen species, DNA, cardiolipin, which can cause NLRP3 inflammasome activation upregulation of IL-18 IL-1β It is not known if mitochondrial damage persists long after ischemia to sustain chronic activation. We conducted a 9-month study Sprague-Dawley rats 45 minutes bilateral renal ischemia. detected glomerular peritubular capillary rarefaction, macrophage...
The Banff working group on preimplantation biopsy was established to develop consensus criteria (best practice guidelines) for the interpretation of kidney biopsies. Digitally scanned slides were used (i) evaluate interobserver variability histopathologic findings, comparing frozen sections with formalin-fixed, paraffin-embedded tissue wedge and needle core biopsies, (ii) correlate findings graft outcome in a cohort biopsies from international medical centers. Intraclass correlations (ICCs)...
Glomerulonephritis is a major cause of morbidity in patients with systemic lupus erythematosus. Although substantial progress has been made the identification pathogenic triggers that result autoantibody production, little known about pathogenesis aggressive proliferative processes lead directly to irreversible glomerular damage and compromise renal function. In this study, we describe model polyinosinic: polycytidylic acid-accelerated nephritis NZB/W mice characterized by severe lesions de...