A5000353884- Blood properties and coagulation
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Platelet Disorders and Treatments
- Diet and metabolism studies
- Liver physiology and pathology
- Venous Thromboembolism Diagnosis and Management
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Vitamin C and Antioxidants Research
- Drug-Induced Hepatotoxicity and Protection
- Obesity, Physical Activity, Diet
- Liver Disease and Transplantation
- Hemoglobinopathies and Related Disorders
- Nutrition, Genetics, and Disease
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Metabolomics and Mass Spectrometry Studies
- Erythrocyte Function and Pathophysiology
- Sulfur Compounds in Biology
- COVID-19 Clinical Research Studies
- Consumer Attitudes and Food Labeling
- Biochemical effects in animals
University Hospital of Geneva
2016-2025
University of Geneva
2014-2025
Hôpital Beau-Séjour
2012-2024
Azienda Ospedaliero-Universitaria Careggi
2013-2024
Geneva College
2011-2024
Faculty (United Kingdom)
2021
University of Florence
2010-2020
Ospedale Santa Maria Goretti
2017-2020
Center for Pediatric Endocrinology Zurich
2020
Service de la Santé Publique
2020
Summary Background Recent studies suggest a role of n‐3 long‐chain polyunsaturated fatty acids (n‐3 PUFA) as peroxisome proliferator‐activated receptor‐ α ligands in improving non‐alcoholic liver disease (NAFLD) rodents. However, data humans are still lacking. Aim To evaluate the efficacy prolonged PUFA supplementation patients with NAFLD. Methods Fifty‐six NAFLD were enrolled. Among overall eligible patients, 42 assumed 1‐g capsule daily for 12 months, whereas 14 refused treatment and...
Abstract Background/Aims: High‐fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) steatohepatitis (NASH). Recent studies have shown an effect of glucagon‐like peptide‐1 (GLP‐1) on hepatic glucose metabolism, although GLP‐1 receptors (GLP‐1r) not been found in human livers. The aim this study was investigate the presence GLP‐1r exenatide, a analogue, signalling. Methods: expression evaluated biopsies livers high‐fat diet‐treated...
To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. This international multidisciplinary initiative included 4 phases: 1) Phase I, generation surveys literature review; 2) II, reduction modified Delphi nominal group technique exercises; 3) III, definition, further guidance real-world patient scenarios, weighting via consensus-based...
Only a few randomized dietary intervention studies that investigated the effects of lacto-ovo vegetarian diet (Vd) in clinically healthy omnivorous subjects are available.We randomly assigned to overweight omnivores with low-to-moderate cardiovascular risk profile low-calorie Vd compared Mediterranean (MD), each lasting 3 months, crossover design. The primary outcome was difference body weight, mass index, and fat changes between 2 groups. Secondary outcomes were differences circulating...
<h3>Objective</h3> To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) EULAR. <h3>Methods</h3> This international multidisciplinary initiative included four phases: (1) Phase I, generation surveys literature review; (2) II, reduction modified Delphi nominal group technique exercises; (3) III, definition, further guidance real-world patient...
Liver perisinusoidal fat-storing cells (FSC) show morphological and ultrastructural characteristics similar to pericytes regulating local blood flow in other organs. In the present study we have analyzed whether FSC respond vasoconstrictors such as thrombin, angiotensin-II, endothelin-1 with an increase intracellular free calcium concentration ([Ca2+]i) coupled effective cell contraction. All agonists tested induced a rapid dose-dependent [Ca2+]i followed by sustained phase lasting several...
Chronic ethanol consumption by baboons (50% of energy from a liquid diet) for 18 to 36 mo resulted in significant depletion hepatic S –adenosyl–L–methionine concentration: 74.6 ± 2.4 nmol/gm vs. 108.9 8.2 liver controls (p < 0.005). The was corrected with (0.4 mg/kcal) administration (102.1 15.4 after –adenosyl–L–methionine-ethanol, 121.4 11.9 controls). Ethanol also induced glutathione (2.63 0.13 μmol/gm 4.87 0.36 controls) that attenuated (3.89 0.51 –adenosyl–L–methionine–methanol 5.22...
Insulin and insulin–like growth factor (IGF–1) are mitogenic for fibroblasts smooth muscle cells. IGF–1 increases in inflamed fibrotic tissues induces proliferation of rat hepatic stellate cells (HSC). This study evaluates the potential roles these hormones development liver fibrosis. receptor expression was evaluated by immunohistochemistry both cultured human HSC tissue. Phosphorylation 70–kd S6 kinase extracellular–regulated (ERK), cell proliferation, type I collagen gene expression,...
Experimental evidence indicates that the lipid peroxidation of biological membranes is often associated with development liver fibrosis. We have studied effect neutrophil-derived reactive oxygen species (ROS) on collagen synthesis by human hepatic stellate cells (HSC), major source in liver, a coculture system. Lipid cocultures was evaluated terms either malondialdehyde (MDA) production or formation MDA/4-hydroxynonenal protein adducts. The expression cellular messenger RNAs (mRNAs) Northern...
Interferon gamma (IFN-gamma) inhibits in vitro the activation of hepatic stellate cells (HSC), primary extracellular matrix-producing liver fibrosis. This study was undertaken to determine vivo effect IFN-gamma rat model fibrosis induced by dimethylnitrosamine (DMN), where HSC represents an early response cell injury. Rats were killed after 1 or 3 weeks treatment with DMN, IFN-gamma, DMN + saline. Immunohistochemistry used identify proliferating (desmin-positive/bromodeoxyuridine...