A5054476150- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- COVID-19 Impact on Reproduction
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Kawasaki Disease and Coronary Complications
- Neonatal and fetal brain pathology
- Blood Coagulation and Thrombosis Mechanisms
- Human Health and Disease
- Congenital Heart Disease Studies
- Pregnancy and preeclampsia studies
- Healthcare Systems and Public Health
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Preterm Birth and Chorioamnionitis
- Cardiovascular and Diving-Related Complications
- Respiratory Support and Mechanisms
- Iron Metabolism and Disorders
- Diabetes Management and Research
- Airway Management and Intubation Techniques
- Cardiovascular Issues in Pregnancy
Yaroslavl State Medical Academy
2023-2025
Russian Medical Academy of Continuous Professional Education
2023-2025
City Clinical Hospital
2023-2025
Ministry of Health of the Russian Federation
2025
The article delves into the systemic inflammatory response syndrome (SIRS), thromboinflammation, and septic shock in fetuses neonates, providing a comprehensive examination of their pathophysiology, diagnostic criteria, clinical implications. It establishes SIRS as hyper-reaction to external stress, disrupting balance between inflammation adaptive mechanisms, driven by cytokines like TNF-α IL-1. fetal (FIRS), subset SIRS, is highlighted for its role adverse neonatal outcomes, including organ...
Development of reference values for both absolute and relative blood levels various types leukocytes as well the neutrophil index (NI) in conditionally “healthy” full-term late premature newborns (LPN) is primarily aimed at determining standards obtained using modern laboratory technologies that would be help recognizing hematological disorders early neonatal period. This continuation research with its initial results previously published Journal “Pediatria. named after G.N. Speransky” 2022,...
The article is dedicated to outlining the pathogenic mechanisms, diagnostic criteria, and treatment of systemic inflammatory response syndrome (SIRS), thromboinflammation, septic shock in fetuses newborns. SIRS a body hyperreaction external stress involving biologically active molecules, cytokines such as tumor necrosis factor-alpha (TNF-α) interleukin (IL) IL-1 so that balance between inflammation adaptive mechanisms becomes altered. Special attention paid fetal (FIRS). Here, we describe...
The article presents the main directions of development modern neonatology and pediatrics early age. Along with unconditional achievements in field nursing newborns, important issues are raised for further improving organization ensuring adequate effective follow-up children after discharge from hospital, which is primarily aimed at outcomes. Early respiratory therapy, open resuscitation priority breastfeeding, treatment prevention bronchopulmonary dysplasia, syncytial viral infection, as...
Early-onset neonatal sepsis (EОNS) is one of the most severe diseases period and often coupled to extremely unfavorable outcomes. In many ways, severity condition results newborn nursing depend on etiology bacterial process. The major EОNS pathogens are traditionally considered be Streptococcus group B E. coli , much less common other Gram-negative bacteria including casuistic cases caused by Proteus mirabilis ( P. ). article provides a review role in developing with pathogen-specific...
Introduction . Early-onset neonatal sepsis (EONS) remains the leading cause of serious mobility and mortality worldwide. At present time, impact COVID-19 pandemic on incidence other infections is particular interest. Aim : to conduct a comparative analysis features course EONS in newborns before (2018) during (2021). Materials Мethods A retrospective cohort single-center continuous study included 73 born hospitalized Regional Kaluga Perinatal Center (PC) based Clinical Hospital. The data for...
Neonatal sepsis still remains a serious problem of modern health care, being one the main causes neonatal and infant mortality, as well disability in surviving children. Due to high risk adverse outcomes, early (ENS), especially preterm infants, attracts special attention. At same time, if previous decades causative agents ENS were Escherichia coli Streptococcus group B, then recent years it has been noted that while maintaining leading value etiological structure , frequency detection...
Introduction . We proposed a hypothesis that prognosis in preterm infants may be affected by concentration of the administered surfactant preparation able to determine its viscosity and, therefore, even distribution throughout lungs. Aim : assess an effect poractant alfa (PA) at low (40 mg/mL) vs. standard (80 without changing recommended dosage (200 mg/kg) on outcomes gestational age (GA) under 32 weeks receiving various respiratory support. Materials and Methods A prospective randomized...
Compared to children of other ages, neonates especially seriously ill and premature subjects comprise a high thrombotic risk group. A decline in the incidence neonatal thrombosis may be accounted for by improved treatment severe conditions newborns increased survival infants. Neonatal adult hemostasis exhibit distinct physiological features: difference concentration, synthesis rate blood coagulation factors, metabolic rate, thrombin plasmin levels. At same time, threshold values natural...
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder leading to severe thrombocytopenia, microangiopathic hemolytic anemia, and target organ microthrombosis. Recently, there has been increasing evidence on the functioning of ADAMTS13 metalloproteinase von Willebrand factor during normal pathological pregnancy, COVID-19 pandemic, etc. However, in neonatal period, TTP characterized by absence “typical” clinical presentation. Most symptoms correlate with other...
COVID-19 is a disease caused by the novel SARS-CoV-2, severe systemic thrombotic syndrome with respiratory tract damage that emerged in 2019 China development of subsequent pandemic. Over past two years, very little information has been accumulated on prevalence, transmission routes, and clinical picture among newborn infants. Given limited data domestic literature, authors present not only description first observation confirmed new coronavirus infection premature newborn, but also brief...
The aim of the study – to analyze morbidity and search for predictors death in premature infants with a gestational age (GA) 32 weeks or less, born perinatal centers received Poractant alfa (PA) treatment respiratory distress syndrome (RDS), order improve quality medical care babies. Materials methods research: multicenter prospective open-label non-randomized continuous comparative was conducted five from 2020 2021. A total 264 patients, inclusion criteria: GA less than weeks, need PA...
One of the leading trends in modern medicine is principle prevention, which consists preventing formation diseases and complications therapy. The main damaging factor during respiratory support patients with inhomogeneous lung tissue injury tidal volume (TV). With traditional pressure controlled mechanical ventilation (PCMV), controlling TV delivered to child difficult due variable properties tissue. PCMV algorithms targeted TV, used neonatology young children, make it possible adjust...
The aim of the study was to analyze respiratory therapy and outcomes nursing preterm infants with gestational age (GA) less than 32 weeks, who received Beractant in various ways order determine most optimal methods surfactant administration. Materials research: a multicenter retrospective cohort study. It carried out nine perinatal centers different regions Russian Federation period from 07/01/2019 06/30/2020. A total 258 GA weeks participated One used – (Survant®) at dose 100 mg/kg for...