A5100649696- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Viral Infectious Diseases and Gene Expression in Insects
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Multiple Myeloma Research and Treatments
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Diabetes Treatment and Management
- Food Quality and Safety Studies
- Protein purification and stability
- Bioactive natural compounds
- Adipose Tissue and Metabolism
- Protein Degradation and Inhibitors
- Erythrocyte Function and Pathophysiology
- Animal Genetics and Reproduction
- Ginseng Biological Effects and Applications
- Parathyroid Disorders and Treatments
- Vitamin C and Antioxidants Research
- Congenital heart defects research
Seoul National University Hospital
2005-2024
Seoul National University
2011-2024
Catholic University of Korea
2020-2023
Seoul St. Mary's Hospital
2020-2023
Samsung Medical Center
2022
Sungkyunkwan University
2014-2022
Korea Food Research Institute
2003-2021
Yeungnam University
2021
Chungnam National University
2005-2014
Catholic University of Daegu
2013
In eukaryotes, the post-translational addition of methyl groups to histone H3 lysine 4 (H3K4) plays key roles in maintenance and establishment appropriate gene expression patterns chromatin states. We report here that an essential locus within chromosome 3L centric heterochromatin encodes previously uncharacterized Drosophila melanogaster ortholog (dSet1, CG40351) Set1 H3K4 methyltransferase (HMT). Our results suggest dSet1 acts as a "global" or general di- trimethyl HMT Drosophila. Levels...
Aquaporins (AQPs) have previously been associated with increased expression in solid tumors. However, its hematologic malignancies including CML has not described yet. Here, we report the of AQP5 cells by RT-PCR and immunohistochemistry. While normal bone marrow biopsy samples (n = 5) showed no AQP5, 32% patient 41) demonstrated expression. In addition, level emergence imatinib mesylate resistance paired (p 0.047). We found that overexpression K562 resulted cell proliferation. small...
Silver nanoparticles (AgNP) are widely used in medical practices owing to their distinct antibacterial, antiviral and anticancer activities. However, with increasing use of AgNP, concerns over its potential toxicity also escalating. Here, we demonstrated the thrombotic effect AgNP which was mediated by procoagulant activity red blood cells (RBCs). In freshly isolated human RBCs, but not silver microparticles (AgMP), elicited morphological changes, phosphatidylserine (PS) exposure...
Potential risk of high-dose vitamin C consumption is often ignored. Recently, gram-dose being intravenously injected for the treatment cancer, which can expose circulating blood cells to extremely high concentrations C. As well as platelets, red (RBCs) actively participate in thrombosis through procoagulant activation. Here, we examined and prothrombotic risks associated with intravenous injection Vitamin (0.5-5 mM) increased activity freshly isolated human RBCs via externalization...
Abstract Helicobacter pylori (H. pylori) infection is on the rise as a cause of immune thrombocytopenia (ITP). It has been suggested that platelet recovery can be achieved following successful microbial eradication, although, exact pathophysiology yet to fully elucidated. This study evaluated long-term effects H. eradication monotherapy count in patients with ITP. was analysed 61 ITP patients. Patients who maintained complete response (CR) for more than six months were classified sustained...
The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (EMPA) and dual SGLT1/2 sotagliflozin (SOTA) are emerging as heart failure (HF) medications in addition to having glucose-lowering effects diabetes mellitus (DM). However, the precise mechanism underlying this cardioprotective effect has not yet been elucidated. Here, we evaluated of EMPA SOTA a zebrafish model DM combined with HF reduced ejection fraction (DM-HFrEF). To compare two drugs, survival, locomotion, myocardial...
Efficient gene delivery of a baculovirus-derived vector (BV-p53-lacZ) to human osteogenic sarcoma cell line, Saos-2, was serendipitously found while evaluating the for p53-null tumour cells in previous study. Therefore, we investigated other human, rat and mouse types lines transduction efficiency via baculovirus vectors containing lacZ reporter under control either cytomegalovirus or Rous virus promoter. The expression beta-galactosidase protein, assessed by X-Gal staining ELISA,...
To evaluate and select microRNAs relevant to acute myeloid leukemia (AML) pathogenesis, we analyzed differential microRNA expression by quantitative small RNA next-generation sequencing using duplicate marrow samples from individual AML patients.For this study, obtained paired at two different time points (initial diagnosis first complete remission status) in patients with AML. Bone were profiled sequencing. Quantification of was performed counting aligned reads genes.Among 38 (32 16 6...
The aim of this study was to investigate the bone regenerative effects fucosterol in estrogen-deficient ovariectomized (OVX) rats.Bone regeneration assessed fucosterol-treated MG63 cells vitro via assays for osteoblast proliferation, alkaline phosphatase, and osteoclast differentiation. Osteoblast proliferation rates, phosphatase activity, mineralization were increased group. Moreover, differentiation osteoclasts decreased In vivo assay, female rats OVX. Twelve weeks after ovariectomy,...
The root bark of Morus alba is commonly used as an alternative medicine due to its numerous health benefits in humans. However, the antidepressant effects various active components from M. have not been fully elucidated. In this study, we aimed determine whether sanggenon G, compound isolated alba, exhibited antidepressant-like activity rats subjected forced swim test (FST)-induced depression. Acute treatment with G (30 mg/kg, intraperitoneally (i.p.)) significantly reduced immobility time...
Abstract: Busulfan and the metabolites of cyclophosphamide are conjugated with glutathione catabolized by enzymes cytosolic S ‐transferases family. There clearly linked single nucleotide polymorphisms in promoter region ‐transferase A1 gene (i.e., GSTA1*A , −567T, −69C −52G; GSTA1*B −567G, −69T −52A). We assessed whether clinical outcomes, including acute graft‐vs.‐host disease, 61 patients hematological malignancies, following HLA‐matched sibling allogeneic stem cell transplantation using...
Mitochondrial metabolism plays a crucial role in insulin resistance and secretion type 2 diabetes mellitus (T2D). Some studies have focused on how Cassia tora extracts affect hyperglycemia. However, the effects of mitochondrial dysfunction associated with not been well explained. In this study, well-known effective compounds extracted from using 70% ethanol were administered to high-fat diet (HFD) fed mouse examine ethanolic (CSEE) pancreas. Furthermore, we examined CSEE regulates basal...
Diabetes mellitus (DM)-associated heart failure (HF) causes high morbidity and mortality. In this study, we established a zebrafish larvae model for in vivo research on diabetic HF.DM-like phenotypes were induced by treating with combination of D-glucose (GLU) streptozotocin (STZ). HF was treatment terfenadine (TER), potassium channel blocker. Additionally, myocardial contractility, motility, viability evaluated.The treated GLU STZ showed significantly higher whole-body glucose...
Seon Young Kim, M.D., Hyun Kyung Kyou Sup Han, Inho Sung-Soo Yoon, Seonyang Park, and Byoung Kook M.D.. Korean J Lab Med 2011;31:1-8. https://doi.org/10.3343/kjlm.2011.31.1.1
Background and Objectives: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown.Methods: We cultured human coronary artery smooth muscle cells (hCSMCs) treated Ang and/or fimasartan.Or we transfected adenoviral vectors expressing CYR61 (Ad-CYR61) or antisense (Ad-As-CYR61).Cellular senescence was evaluated senescence-associated β-galactosidase (SA-β-gal) assay.The mechanisms were investigated real-time PCR western...