A5022679014- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Pharmacological Effects of Natural Compounds
- Complementary and Alternative Medicine Studies
- Diet and metabolism studies
- Bioactive Compounds and Antitumor Agents
- Pharmacology and Obesity Treatment
- Cytokine Signaling Pathways and Interactions
- Food Quality and Safety Studies
- Myofascial pain diagnosis and treatment
- Gastrointestinal motility and disorders
- NF-κB Signaling Pathways
- Bone Metabolism and Diseases
- Dietary Effects on Health
- Gut microbiota and health
- Shoulder Injury and Treatment
- Phytoestrogen effects and research
- Orthopedic Surgery and Rehabilitation
- Phytochemistry and Bioactive Compounds
- Clinical practice guidelines implementation
- Temporomandibular Joint Disorders
- Asthma and respiratory diseases
Hospital Authority
2025
Kyung Hee University Medical Center
2021-2024
Kyung Hee University
2015-2024
Dunsan Korean Medicine Hospital
2023-2024
Weatherford College
2022
Creative Commons
2022
Yahoo (United Kingdom)
2022
Cell Biotech (South Korea)
2011-2014
Kyung Hee University East-West Neo Medical Center
2008
Background: The clinical effect of probiotics on irritable bowel syndrome (IBS) is still controversial. Aims: We aimed to evaluate the effects a probiotic mixture IBS symptoms and composition fecal microbiota in patients with diarrhea-dominant (D-IBS). Methods: Fifty D-IBS were randomized into placebo or (Lactobacillus acidophilus, Lactobacillus plantarum, rhamnosus, Bifidobacterium breve, lactis, longum, Streptococcus thermophilus 1.0×1010 CFU) groups. Treatment was taken daily for 8 weeks....
Abstract Background and Aim The efficacy of treatment with multispecies probiotics on irritable bowel syndrome ( IBS ) symptoms the alterations gut microbiota in patients who have taken were investigated. Methods This randomized, double‐blind, placebo‐controlled trial involved 49 (probiotics: 25, placebo: 24) diagnosed according to R ome III criteria. Patients randomly assigned two groups: either receive (a mixture B ifidobacterium longum , . bifidum lactis L actobacillus acidophilus...
Background: This trial assessed the feasibility of titrating evening dosing anti-hypertensive medications based on nighttime home blood pressure measurement (HBPM) readings in primary care for hypertensive (HT) patients.
Multicenter, randomized, patient-assessor blind, sham-controlled clinical trial.To investigate the efficacy of acupuncture treatment with individualized setting for reduction bothersomeness in participants chronic low back pain (cLBP).Low is one main reasons disability among adults working age. Acupuncture known as an effective cLBP, but it remains unclear whether superior to placebo.One hundred thirty aged 18 65 years nonspecific LBP lasting at least last 3 months prior trial participated...
Aim: Although numerous animal studies suggest that probiotic therapy has beneficial effects in various liver diseases, the evidence for human disease is controversial. This study was carried out to investigate efficacy of alleviating small intestinal bacterial overgrowth (SIBO) and permeability chronic disease. Methods: Fifty-three patients with were randomized either or placebo. Six species used: Bifidobacterium bifidum, lactis, longum, Lactobacillus acidophilus, rhamnosus, Streptococcus...
6‐shogaol (6SG), one of active ingredients in ginger ( Zingiber officinale ), is known to exhibit anti‐proliferative, anti‐metastatic, and pro‐apoptotic activities through a mechanism that not fully elucidated. Because the aberrant activation STAT3 MAPKs have been associated with regulation proliferation, invasion, metastasis tumors, we hypothesized 6SG modulates tumor cells. We found strongly inhibited constitutive phosphorylation inhibition upstream JAK2 c‐Src kinases nuclear translocation...
The aerial parts of Artemisia capillaris (Compositae) have been used in traditional Korean medicine as a cholagogic, antipyretic, anti-inflammatory, and diuretic purposes. In our previous study, ethanolic extracts the plant demonstrated marked anti-inflammatory effect lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (J. Soc. Appl. Biol. Chem., 2010, 53, 275-282). present capillarisin (CPS), flavone, main constituent A. capillaris, was examined for its activity cells. We found that CPS...
Introduction. Although combination therapy with herbal medicine and probiotics is gaining popularity for controlling diarrhea-dominant irritable bowel syndrome (D-IBS) symptoms, few studies have investigated its clinical effects. Materials Methods. Fifty-three patients D-IBS were randomly allocated into 1 of the following 4 groups: (Gwakhyangjeonggisan; GJS) plus (Duolac7S; DUO), GJS placebo DUO, DUO. The study period consisted a 2-week run-in, 8 weeks administration, 2 follow-up. primary...
Cinobufagin (CBG) is a cardiotoxic bufanolide steroid secreted by the skin and parotid venom glands of Asiatic toad Bufo bufo gargarizans (called Chan-Su). Although CBG known to exhibit anti-cancer activities, very little about its potential mechanism(s) action. In this study, we investigated whether mediates effect through modulation mitogen-activated protein kinases (MAPKs) signaling pathway in human multiple myeloma (MM) U266 cells. We found that caused significant activation ERK, JNK p38...
Auriculotherapy has long been used to treat various diseases. We analyzed and visualized auriculotherapy's geographical distribution, key contributors, thematic trends over the past 20 years provide current in auriculotherapy field offer recommendations for future research directions.
Oldenlandia diffusa (OD) has been used as a natural drug for the treatment of cancer in Asia and specifically Korea. However, antiinflammatory mechanisms employed by OD have yet to be completely understood. This study attempted determine effects hentriacontane, one constituent compounds OD, on lipopolysaccharide (LPS)‐induced inflammatory responses mouse peritoneal macrophages. The findings this showed that inhibited production tumor necrosis factor (TNF)‐α, interleukin (IL)‐6 prostaglandin...
Obesity is a serious global health challenge, closely associated with numerous chronic conditions including type 2 diabetes. Anemarrhena asphodeloides Bunge (AA) known as Jimo has been used to address pathogenic heat such wasting-thirst in Korean Medicine. Timosaponin A3 (TA3), natural compound extracted from AA, demonstrated potential therapeutic effects various disease models. However, its on diabetes and obesity remain largely unexplored. We investigated the anti-obesity anti-diabetic...
This study investigated the effects of fucoidan (extract from Hizikia fusiforme) on symptoms and inflammatory cytokine activation in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Forty male SD were divided into five groups, including normal, negative control (MIA), positive (Lyprinol), two experimental groups treated 50 or 100 mg/kg fucoidan. Weight-bearing assessments done after MIA injection right knee to induce OA. After 14 days treatment, microcomputed tomographic...
Obesity is a risk factor for metabolic diseases including type 2 diabetes, nonalcoholic steatohepatitis (NASH), heart diseases, and cancer. This study aimed to investigate the anti-obesity effect of Polygalin C (PC) isolated from Polygala japonica Houtt. in 3T3-L1 adipocytes. Based on Oil Red O assay results, PC significantly decreased lipid accumulation compared control. We found that suppressed adipogenesis transcription factors peroxisome proliferator-activated receptor γ (PPAR γ)...
This study investigated the effects of Lycium chinense Mill (LCM) extract on obesity and diabetes, using both in vitro high-fat diet (HFD)-induced mouse models. We found that LCM notably enhanced glucagon-like peptide-1 (GLP-1) secretion NCI-h716 cells from 411.4 ± 10.75 pg/mL to compared NT (78.0 0.67 pg/mL) without causing cytotoxicity, implying involvement Protein Kinase A C (PKA C) AMP-activated protein kinase (AMPK) its action mechanism. also decreased lipid droplets lowered expression...
The aim of this study was to analyze published papers on the use herbal medicine in obesity research over past 20 years using bibliometric methods and present an overview global trends.
Chelidonic acid (CA) is a γ-pyrone which contained in the rhizome of Chelidonium majus L. It has multiple pharmacological effects including those mild analgesic, an antimicrobial, oncostatic and central nervous system sedative, but anti-inflammatory effect CA its molecular mechanisms are poorly understood. In this study, we investigated regulatory mechanism mast cell-mediated inflammatory response by phorbol 12-myristate 13-acetate calcium ionophore A23187. The results indicate that inhibits...