Using a HeLa cell line stably transfected with the tat gene from human immunodeficiency virus type 1, we have found that expression of regulatory Tat protein suppresses cellular Mn-containing superoxide dismutase (Mn-SOD). This enzyme is one cell's primary defenses against oxygen-derived free radicals and vital for maintaining healthy balance between oxidants antioxidants. The parental cells expressed nearly equivalent amounts Cu,Zn- Mn-SOD isozymes. Those expressing protein, however,...

Background and Aim Increasing evidence has indicated a close association of host-gut flora metabolic interaction with obesity. Flos Lonicera, traditional herbal medicine, is used widely in eastern Asia for the treatment various disorders. The aim this study was to evaluate whether unfermented or fermented formulations Lonicera could exert beneficial impact combat obesity related endotoxemia. Methods Obesity endotoxemia were induced separately together rats through feeding eight-week high fat...

Accumulating evidence suggests relationship of compositional changes gut microbiota with onset metabolic disorders and obesity. Kimchi, a traditional Korean side dish, is known for its beneficial impact on parameters anti-obesity effects. The current study was designed to evaluate the association between human genome after kimchi intervention in an effort understand molecular mechanism(s) underlying antiobesity kimchi. Twenty-four obese women were randomly assigned either fresh or fermented...

Abstract Accumulating evidence suggests the anti-inflammatory and anti-obesity activities of Rhizoma Atractylodis Macrocephalae (RAM). Here, we evaluated impact unfermented (URAM) versus fermented RAM (FRAM) using both in vitro vivo models. Both URAM FRAM exhibited marked anti-inflammatory, anti-adipogenic modulation gut microbial distribution. However, FRAM, compared to URAM, resulted more efficient suppression NO production normalization transepithelial electrical resistance LPS-treated...

The identification of new probiotics with anti-obesity properties has attracted considerable interest. In the present study, activities Akkermansia muciniphila (A. muciniphila) strains isolated from human stool samples and their relationship gut microbiota were evaluated using a high fat-diet (HFD)-fed mice model. Three A. chosen 27 isolates selected based on anti-lipogenic activity in 3T3-L1 cells. anti-lipogenic, anti-adipogenic these three further HFD-induced obese mice. animals...

Obesity has become a major global health challenge due to its increasing prevalence, and the associated risk. It is main cause of various metabolic diseases including diabetes, hypertension, cardiovascular disease, stroke certain forms cancer.In present study we evaluated anti-obesity property Daesiho-tang (DSHT), an herbal medicine, using high fat diet (HFD)-induced obese mice as model. Our results showed that DSHT ameliorated body weight gain, decreased total fat, regulated expression...

Purpose: Metformin and Houttuynia cordata are representative anti-diabetic therapeutic agents in western oriental medicinal fields, respectively. The present study examined the effects of houttuynia extract (HCE) metformin combination a dysmetabolic mouse model. Methods: Metabolic disorders were induced C57BL/6J mice by high fat diet (HFD) for 14 weeks. Results: Combination HCE significantly lowered body weight, abdominal fat, perirenal liver kidney weights, but did not change epididymal...

Akkermansia muciniphila (A. muciniphila) is a promising probiotic candidate owing to its health-promoting properties. A previous study reported that the pasteurized form of A. strains isolated from human stool samples had beneficial impact on high-fat diet-induced obese mice. On other hand, differences in effects between live and metabolism immune system host are still inconclusive. This examines forms lipid glucose regulating inflammatory responses using HFD-fed mouse model. The animals...

Lipopolysaccharide (LPS), a potent inducer of systemic inflammatory responses, is known to cause impairment intestinal barrier function. Here, we evaluated the in vitro protective effect an unfermented formulation Rhizoma Atractylodis Macrocephalae (RAM), traditional Chinese herbal medicine widely used treatment many digestive and gastrointestinal disorders, two fermented preparations RAM, designated as FRAM-1 (prepared Luria-Bertani broth) FRAM-2 glucose), on epithelial cells (IECs) against...

The radix of Scutellaria baicalensis (SB) is a herb widely used in traditional Chinese medicine to treat metabolic diseases. Several main components, including baicalin and wogonoside, possess anti-dyslipidemia, anti-obesity anti-diabetic effects. We hypothesized that co-administration SB extract metformin exerts better effect on obesity-induced insulin resistance lipid metabolism than treatment with alone. compared the (100 mg/10 mL/kg/day) alone mg/5 (200 Otsuka Long Evans Tokushima Fatty...

Oral administration of steamed roots of<italic>Rehmannia glutinosa</italic>Libosch for eight weeks resulted in significantly decreased waist circumference and the alteration gut microbial community.

The gut microbiota is important in energy contribution, metabolism and immune modulation, compositional disruption of the population closely associated with chronic metabolic diseases like type 2 diabetes (T2D) non-alcoholic fatty liver disease (NAFLD). Metformin (MET) Flos Lonicera (FL) are common treatments for Western Oriental medicinal fields. We evaluated effect treatment FL MET combination on hepatosteatosis, glucose tolerance, microbial composition. were administered to Otsuka...

Research Article| March 01 1960 Amino acid sequence in mycobacillin S. K. Majumdar; Majumdar 1Department of Applied Chemistry, University College Science and Technology, Calcutta, India Search for other works by this author on: This Site PubMed Google Scholar Bose Biochem J (1960) 74 (3): 596–599. https://doi.org/10.1042/bj0740596 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn MailTo Cite Get Permissions Citation...

Metformin and Houttuynia cordata are representative anti-diabetic therapeutics in western oriental medicine, respectively. The current study examined the synergistic effect of extraction (HCE) metformin combination Otsuka Long–Evans Tokushima Fatty (OLETF) rats. Fecal microbiota were analyzed by denaturing gradient gel electrophoresis (DGGE) real-time PCR. Combining HCE + resulted significantly ameliorated glucose tolerance (oral test (OGTT))—the same as alone. Particularly, results insulin...

The brain, gut, and adipose tissue interact to control metabolic pathways, impairment in the brain-gut-adipose axis can lead disorders, including obesity. Chowiseungcheng-tang (CST), a herbal formulation, is frequently used treat disorders. Here, we investigated anti-obesity effect of CST its link with using C57BL/6J mice as model. animals were provided normal research diet (NRD) or high-fat (HFD) absence presence orlistat (ORL) for 12 weeks. had significant on number vital obesity-related...

Background: Puerariae Radix (PR), the dried root of Pueraria lobata, is reported to possess therapeutic efficacies against various diseases including obesity, diabetes, and hypertension. Fermentation-driven bioactivation herbal medicines can result in improved potencies efficacies. Methods: C57BL/6J mice were fed a high-fat diet fructose water with PR (400 mg/kg) or fermented by Bifidobacterium breve for 10 weeks. Histological staining, qPCR, Western blot, 16s rRNA sequencing used determine...