Akkermansia muciniphila, a promising candidate for next-generation probiotics, exhibits significant genomic diversity, classified into several distinct clades (AmI to AmIV). Notably, single clade tends predominate within individual hosts, with co-occurrence of different being rare. The mechanisms driving such clade-specific exclusion remain unclear. Here, we show that extracellular vesicles (EVs) derived from AmII inhibit the growth I (AmI), conferring competitive advantage AmII. Moreover,...

Abstract Background Probiotic lactic acid bacteria (LAB) support a functional and balanced immune system, contribute to modulatory effects in combatting microbial pathogens, including viruses. Most cervical cancers are associated with anogenital region infection high-risk (HR) human papillomavirus (HPV). In this study, we analyzed the antiviral activity of Bifidobacterium adolescentis SPM1005-A SiHa cancer cell line expressing HPV type 16. Methods We assessed cellular toxicity B. cells by...

The identification of new probiotics with anti-obesity properties has attracted considerable interest. In the present study, activities Akkermansia muciniphila (A. muciniphila) strains isolated from human stool samples and their relationship gut microbiota were evaluated using a high fat-diet (HFD)-fed mice model. Three A. chosen 27 isolates selected based on anti-lipogenic activity in 3T3-L1 cells. anti-lipogenic, anti-adipogenic these three further HFD-induced obese mice. animals...

Nonalcoholic steatohepatitis (NASH) is an advanced nonalcoholic fatty liver disease characterized by chronic inflammation and fibrosis. A dysbiosis of the gut microbiota has been associated with pathophysiology NASH, probiotics have proven helpful in its treatment prevention. Although both traditional next-generation potential to alleviate various diseases, studies that observe therapeutic effect on NASH are lacking. Therefore, we investigated whether a probiotic candidate, Faecalibacterium...

Akkermansia muciniphila (A. muciniphila) is a promising probiotic candidate owing to its health-promoting properties. A previous study reported that the pasteurized form of A. strains isolated from human stool samples had beneficial impact on high-fat diet-induced obese mice. On other hand, differences in effects between live and metabolism immune system host are still inconclusive. This examines forms lipid glucose regulating inflammatory responses using HFD-fed mouse model. The animals...

Abstract Atopic dermatitis (AD) is a common inflammatory skin disease, and its pathogenesis closely associated with microbial homeostasis in the gut, namely gut-skin axis. Particularly, recent metagenomics studies revealed that abundance of two major bacterial species Faecalibacterium prausnitzii Akkermansia muciniphila , may play critical role AD, but effect these AD has not yet been elucidated. To evaluate potential beneficial F. or A. we conducted an animal model study where EB-FPDK11...

Introduction Obesity and related metabolic issues are a growing global health concern. Recently, the discovery of new probiotics with anti-obesity properties has gained interest. Methods In this study, four Faecalibacte-rium prausnitzii strains were isolated from healthy human feces evaluated on high-fat diet-induced mouse model for 12 weeks. Results The F. reduced body weight gain, liver fat weights, calorie intake while improving lipid glucose metabolism in adipose tissue, as evidenced by...

Ginseng is a profitable crop worldwide; however, the ginseng replanting problem (GRP) major threat to its production. Soil amendment non-chemical method that gaining popularity for alleviating continuous cropping obstacles, such as GRP. However, impact of soil with either cow dung or canola on GRP reduction and associated microbiota remains unclear. In present study, we evaluated effect dung, seed powder, without (control), survival seedling transplants, bacterial fungal communities, their...

Spinach has been suggested as a potential rotation crop for increasing yield by enhancing beneficial fungal microbes in continuous monocropping. However, no research on the use of spinach green manure reported. Thus, we tested effects and Korean mustard cultivars (green red mustards) (10 g pot -1) soil chemical properties, pepper productivity, microbiome long-year pepper-monocropped soil. improved nutrition (e.g., pH, SOM, TN, NH4+, K), weed suppression, growth. had far highest fruit yield,...

Objectives: This study aimed to investigate the relationship between excessive postpartum iodine intake and incidence of thyroid disease in mothers, as well child growth development. Methods: Of 1054 participants 2019 nationwide survey that assessed maternal intake, 684 mothers participated a follow-up study. Data on development from infant or toddler health checkups were collected. Iodine nutrient using food frequency questionnaire, serum hormones (triiodothyronine (T3), thyroid-stimulating...

Abstract Synaptic elements based on memory devices play an important role in boosting neuromorphic system performance. Here, we show two types of fab-friendly HfO 2 material-based resistive memories categorized by configuration and operating principle for a suitable analog synaptic device aimed at inference training neural networks. Since the task is mainly related to number states from recognition accuracy perspective, first demonstrate multilevel cell (MLC) properties compact two-terminal...

Tomato is an economically and nutritionally important crop vulnerable to drought. Under drought, soil microbes provide beneficial effects plants alleviate stress. We suggest a reconstruction of the microbiome using biofumigation, organic farming method, protect tomatoes. In this study, we treated in four ways with varied concentrations: biofumigation (BF0.5, BF1.0, BF1.5), green manure treatment (GM0.5, GM1.0, GM1.5), autoclaving (AT), non-treatment (NT). Tomatoes were grown each soil,...

Peach gummosis disease has been identified as a serious challenge in Korean agriculture and developed to become major cause of agricultural productivity losses. However, treatments for have not systemically established studies the microbiome closely related this plant are lacking. Therefore, we analyzed bacterial fungal communities bark rhizosphere soil healthy peach trees those with gummosis. Through high-throughput sequencing, obtained unprecedented insights into dynamics each group,...

The radiological and clinical significance of a dilated Virchow-Robin space (dVRS) in the striatum (STR) remains unclear. We investigated role dVRS STR on parkinsonism dopamine transporter positron emission tomography (DaT-PET) findings.Patients with who underwent both brain magnetic resonance imaging DaT-PET were included. Clinical status was evaluated by Hoehn Yahr (HY) stage, Korean-Mini Mental Status Examination (K-MMSE), Montreal Cognitive Assessment Korea (MoCA-K), Frontal Battery...

Omega-3 fatty acid (n-3 FA) intake is known to have a preventive effect on depressive symptoms in general population. This study assessed the effects of n-3 FA and brain function middle-aged women. Depressive were screened using Beck Depression Inventory-II (BDI-II) Center for Epidemiologic Studies-Depression scale (CES-D) assessment questionnaires, intakes semiquantitative food frequency questionnaire. We found that negatively associated with Psychiatrists diagnosed presence disorders 5th...

Abstract Background Biofumigation is a non-chemical sustainable approach that reshapes soil microbiota to overcome challenges in way of continuous cultivation. However, the type and quantity substrate have significant impact on shifts subsequent success biofumigation. Moreover, studies effects biofumigant concentration combination with fumigation duration dynamics are very rare. Research methods We performed microcosm experiments investigate how (Korean canola cultivar, HanRa) at various...

Purpose:The purpose of this study was to investigate the differences in portion size 11 types foods that Korean adults frequently consume, based on parameters eating place, gender, and age using Korea National Health Nutrition Examination Survey (KNHANES) data.Methods: The dietary survey data from 2012-2016 KNHANES used.A total 19,779 subjects (8,034 male [40.6%], 11,745 female [59.4%]) were classified three groups (19-29 years old [15.7%], 30-49 [46.9%], 50-64 [37.4%]) places (home,...

프로바이오틱스는 미생물 식품 보조제 또는 건강증진을 위해 전통적으로 유제품에 첨가되어온 세균의 구성요소이다. 본 연구에서는 프로바이오틱스로 이용되는 Bifidobacterium adolescentis SPM0212 균주의 간 보호효과를 평가하였으며, 이전 B형 간염 바이러스에 항 바이러스 활성을 나타내는 균주로 확인되었다. 연구는 Wistar albino 랫드를 이용하여 수행되었으며 프로바이오틱스를 연속해서 9일 동안 경구로 투여하고 7일째와 8일째에는 사염화탄소를 투여하여 급성 손상을 유도하였다. 손상 정도는 혈중 glutamate oxaloacetate transaminase (SGOT)와 pyruvate (SGPT)의 수치와 병리조직학적 시험을 통해 평가하였다. 그 결과, B. SPM0212는 SGOT와 SGPT 수치의 증가를 유의적으로 억제하였으며, 사염화탄소가 체중과 장기무게에 미치는 부정적인 영향을 감소시켰다. 또한 시험결과, 사염화탄소만 투여한 랫드의 간은...

We recently developed a multiplex diagnostic kit, QPLEX™ Alz plus assay which captures amyloid-β1-40, galectin-3 binding protein, angiotensin-converting enzyme, and periostin simultaneously using microliters of peripheral blood utilizes an optimized algorithm for screening Alzheimer’s disease (AD) by correlating with cerebral amyloid deposition. Owing to the demand early AD detection, we investigate potential our kit clinical diagnosis AD. A total 1395 participants were recruited, their...