A5045536786- Gut microbiota and health
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Nutritional Studies and Diet
- Mesenchymal stem cell research
- Retinal Development and Disorders
- CRISPR and Genetic Engineering
- Liver Disease Diagnosis and Treatment
- Probiotics and Fermented Foods
- Tissue Engineering and Regenerative Medicine
- Lysosomal Storage Disorders Research
- Nutrition, Health and Food Behavior
- Photopolymerization techniques and applications
- Drug Transport and Resistance Mechanisms
- Neurogenetic and Muscular Disorders Research
- MicroRNA in disease regulation
- Menstrual Health and Disorders
- Gastrointestinal motility and disorders
- IL-33, ST2, and ILC Pathways
- Renal and related cancers
- Retinoids in leukemia and cellular processes
- Food composition and properties
- Electrolyte and hormonal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Polysaccharides and Plant Cell Walls
Korea Food Research Institute
2019-2023
Seoul National University
2015-2022
Inha University
2012
Catholic University of Korea
2008
A large number of microorganisms reside within the gastrointestinal tract, especially in colon, and play important roles human health disease. The composition gut microbiota is determined by intrinsic host factors environmental factors. While investigating to promote great interest, few studies have focused on their effect microbiota. This study aimed investigate differences according lifestyle geographical area, even people with similar genetic background.We enrolled ten nine elderly women...
Mesenchymal stem cell (MSC) has been applied for the therapy of allergic disorders due to its beneficial immunomodulatory abilities. However, underlying mechanisms therapeutic efficacy are reported be diverse according source isolation or route administration. We sought investigate safety and human adipose tissue-derived MSCs (hAT-MSCs) in mouse atopic dermatitis (AD) model determine distribution cells after intravenous Murine AD was established by multiple treatment Dermatophagoides...
Nonalcoholic steatohepatitis (NASH) is an advanced nonalcoholic fatty liver disease characterized by chronic inflammation and fibrosis. A dysbiosis of the gut microbiota has been associated with pathophysiology NASH, probiotics have proven helpful in its treatment prevention. Although both traditional next-generation potential to alleviate various diseases, studies that observe therapeutic effect on NASH are lacking. Therefore, we investigated whether a probiotic candidate, Faecalibacterium...
The Westernized diet has been associated with the pathogenesis of metabolic diseases, whereas a Korean reported to exert beneficial effects on health in several studies. However, Western and diets gut microbiome host metabolome are unclear. To examine diet-specific metabolome, we conducted randomized crossover clinical trial typical (TKD), American (TAD), recommended (RAD). involved 4-week consumption an experimental followed by 2-week interval before crossover. 16S rRNA sequencing analysis...
Dark chocolate has long been recognized for its mood-altering properties; however, the evidence regarding emotional effects of daily dark intake is limited. Therefore, we aimed to investigate on mood in everyday life, with special emphasis gut-brain axis. Two different chocolates (85% and 70% cocoa content) were tested this study. In a randomized controlled trial, healthy adults (20–30 y) consumed either 30 g/d 85% (DC85, n=18); (DC70, n=16); or no (control group, CON; n=14); 3 weeks. Mood...
Evidence on whether prior antibiotic (pATB) administration modulates outcomes of programmed cell death protein-1 (PD-1) inhibitors in advanced gastric cancer (AGC) is scarce. In this study, we find that pATB consistently associated with poor progression-free survival (PFS) and overall (OS) multiple cohorts consisting patients AGC treated PD-1 inhibitors. contrast, does not affect among irinotecan. Multivariable analysis the confirms independently predicts worse PFS OS. Administration pATBs...
Abstract Gut microbiota is suggested to regulate the host’s mental health via gut-brain axis. In this study, we investigated relationship between microbiome and psychological pain due social exclusion. Adult individuals with ( n = 14) without 25) exclusion experience were assessed for status using self-reported questionnaires: Beck Anxiety Inventory (BAI), Depression Inventory, UCLA Loneliness Scale. The gut was analyzed by 16 S rRNA gene sequencing bioinformatics. group had a 1.70-fold...
Introduction Obesity and related metabolic issues are a growing global health concern. Recently, the discovery of new probiotics with anti-obesity properties has gained interest. Methods In this study, four Faecalibacte-rium prausnitzii strains were isolated from healthy human feces evaluated on high-fat diet-induced mouse model for 12 weeks. Results The F. reduced body weight gain, liver fat weights, calorie intake while improving lipid glucose metabolism in adipose tissue, as evidenced by...
Microglia can aggravate olfactory dysfunction by mediating neuronal death in the bulb (OB) of a murine model Niemann-Pick disease type C1 (NPC1), fatal neurodegenerative disorder accompanied lipid trafficking defects. In this study, we focused on crosstalk between neurons and microglia to elucidate mechanisms underlying extensive microgliosis NPC1-affected brain. OB NPC1 mice strongly expressed CX3C chemokine receptor 1 (Cx3cr1), specific for neural C-X3-C motif ligand (Cx3cl1). addition,...
Characterizing the gut microbiome in healthy population is first step elucidating its associations with host health conditions. Populations different diet patterns, lifestyles, and genetic backgrounds harbor microbes. In this study, we characterized of 890 Koreans using 16S rRNA sequencing. The Korean harbored a relatively large fraction Prevotella enterotype presented distinctive microbiome, compared to that populations other countries. Additionally, determined clusters cooccurring microbes...
For the application of mesenchymal stem cells (MSCs) as clinical therapeutics, regulation cellular aging is important to protect hMSCs from an age-associated decline in their function. In this study, we evaluated effects hypoxia on senescence and immunomodulatory abilities hUCB-MSCs. Hypoxic-cultured hUCB-MSCs showed enhanced proliferation had increased immunosuppressive mitogen-induced mononuclear cell proliferation. We found that BMI1, a member polycomb repressive complex protein group,...
Neural stem cells (NSCs) are a prominent cell source for understanding neural pathogenesis and developing therapeutic applications to treat neurodegenerative disease because of their regenerative capacity multipotency. Recently, variety cellular reprogramming technologies have been developed facilitate in vitro generation NSCs, called induced NSCs (iNSCs). However, the genetic safety aspects established virus-based methods considered, non-integrating developed. Reprogramming with transcribed...
Niemann-Pick disease type C (NPC) is a neurodegenerative and lysosomal lipid storage disorder, characterized by the abnormal accumulation of unesterified cholesterol glycolipids, which caused mutations in NPC1 genes. Here, we report generation human induced neural stem cells from NPC patient-derived fibroblasts (NPC-iNSCs) using only two reprogramming factors SOX2 HMGA2 without going through pluripotent state. NPC-iNSCs were stably expandable differentiated into neurons, astrocytes,...
Retinal pigment epithelium (RPE) is a major component of the eye. This highly specialized cell type facilitates maintenance visual system. Because RPE loss induces an irreversible impairment, generation techniques have recently been investigated as potential therapeutic approach to degeneration. A microRNA-based technique new strategy for producing cells from adult stem sources. Previously, we identified that antisense microRNA-410 (anti-miR-410) differentiation amniotic epithelial cells. In...
// Soon Won Choi 1, 2, * , Ji-Hee Shin Jae-Jun Kim 2 Tae-Hoon Yoojin Seo Hyung-Sik 3, 4 Kyung-Sun Kang 1 Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, 08826, Republic Korea Institute for Science, 3 Pusan University School Busan 49241, Biomedical Institute, Hospital, These authors contributed equally to this work Correspondence to: Kang, email: kangpub@snu.ac.kr Keywords: miR-203, photoreceptor, neural retina, AESC, UCB-MSC Received: January 07,...
Recent advances have shown the direct reprogramming of mouse and human fibroblasts into induced neural stem cells (iNSCs) without passing through an intermediate pluripotent state. Thus, strategy possibly provides a safe homogeneous cellular platform. However, applications iNSCs for regenerative medicine are limited by restricted availability cell sources. Human umbilical cord blood (hUCB) hold great potential in that immunotyped hUCB units can be immediately obtained from public banks....
Abstract The response rate to obeticholic acid (OCA), a potential therapeutic agent for non-alcoholic fatty liver disease, is limited. This study demonstrated that upregulation of the alternative bile synthesis pathway increases OCA treatment rate. hepatic transcriptome and metabolite profile analyses revealed (Cyp7b1 muricholic acid) in OCA-responder group were upregulated compared with those OCA-non-responder group. Intestinal microbiome analysis also abundances Bacteroidaceae,...
Abstract This study sought to characterize the impact of long-term dehydration in terms physiological and biochemical parameters, as well renal transcriptomes. Furthermore, we assessed whether consumption specific types water elicit more beneficial effects on these health parameters. To this end, C57BL/6 mice were either provided for 15 min/day over 2 4 weeks (water restricted; RES), or ad libitum access distilled (CON), tap, spring, purified water. Results show that restriction decreases...
Although pluripotent stem cell (PSC) therapy has advantages for clinical applications because of the self-renewal and multi-lineage differentiation abilities PSCs, it also disadvantages in terms potential PSCs to undergo malignant transformation or unexpected differentiation. The prevention teratoma formation is largest hurdle all. Despite intensive studies that have investigated ways block teratomas, such methods yet be further developed use. Here, a new approach focused on exerting...
Saengshik is a type of meal-replacement product or dietary supplement comprising an uncooked and dried plant-based food mixture with various health-promoting properties, such as antidiabetic, anti-dyslipidemic, antioxidant, anticancer properties. Although these properties are considered attributable to the bioactive components absorbed through intestine its remolding effect on intestinal microorganisms, supplementation gut microbiota profiles has not yet been studied. In this study, we...
The market for probiotics has grown exponentially in recent decades. Owing to the diversification of probiotic products, researchers who focus on issues related their quality, safety, and efficacy have highlighted need identify specific strains, such as Lactobacillus acidophilus. However, phylogenetic analyses based 16S rRNA gene sequence differences cannot distinguish L. acidophilus strains or some species. Recent studies demonstrated value clustered regularly interspaced short palindromic...
Habitual diet influences the intestinal microbiota and metabolites profiles, thereby influencing host physiology. In particular, westernized can contribute to pathogenesis of metabolic disease whereas, traditional Korean (TK) which is rich in plant-based products low animal fat protein provides health benefits. However, both from gut microbial point view, exact comparing TK regard biological mechanisms development have not been studied yet. Therefore, aim this study was compare effect...