A5065932837- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Advanced Glycation End Products research
- Diet and metabolism studies
- Tryptophan and brain disorders
- Connexins and lens biology
- Gastrointestinal motility and disorders
- Fatty Acid Research and Health
- Genomics, phytochemicals, and oxidative stress
- Calpain Protease Function and Regulation
- Biochemical effects in animals
- Mesenchymal stem cell research
- S100 Proteins and Annexins
- Heat shock proteins research
- Dermatology and Skin Diseases
- Probiotics and Fermented Foods
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Cancer, Stress, Anesthesia, and Immune Response
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- Telomeres, Telomerase, and Senescence
- Neurological Disease Mechanisms and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Muscle metabolism and nutrition
Daegu Fatima Hospital
2019
Seoul National University
2014-2017
Cell Biotech (South Korea)
2016-2017
Inha University
2008-2014
Stress is a potent risk factor for depression, yet the underlying mechanism not clearly understood. In present study, we explored of development and maintenance depression in stress-induced animal model. Mice restrained 2 h daily 14 d showed distinct depressive behavior, altered behavior persisted >3 months absence intervention. Acute restraint induced surge oxidative stress brain, progressively increased with repetition stress. <i>In vitro</i>, hormone glucocorticoid generated superoxide...
Noninvasive intranasal drug administration has been noted to allow direct delivery of drugs the brain. In present study, therapeutic efficacy small interfering RNA (siRNA) was investigated in postischemic rat Fluorescein isothiocyanate (FITC)-labeled control siRNA delivered intranasally normal adult rats using e-PAM-R, a biodegradable PAMAM dendrimer, as gene carrier. Florescence-tagged found cytoplasm and processes neurons glial cells many brain regions, including hypothalamus, amygdala,...
Abstract We investigated the neuroprotective effect of glucosamine (GlcN) in a rat middle cerebral artery occlusion model. At highest dose used, intraperitoneal GlcN reduced infarct volume to 14.3% ± 7.4% that untreated controls and afforded reduction motor impairment neurological deficits. Neuroprotective effects were not reproduced by other amine sugars or acetylated‐GlcN, suppressed postischemic microglial activation. Moreover, lipopolysaccharide (LPS)‐induced upregulation proinflammatory...
Human mesenchymal stem cells (hMSCs) have great therapeutic potential due to their high plasticity, immune privileged status and ease of preparation, as well a lack ethical barriers use. However, ultimate usefulness is limited by cellular senescence occurring secondary increased levels reactive oxygen species (ROS) during propagation in culture. The underlying molecular mechanisms responsible for this process hMSCs remain unclear. An antioxidant polyphenol epigallocatechin-3-gallate (EGCG)...
The identification of new probiotics with anti-obesity properties has attracted considerable interest. In the present study, activities Akkermansia muciniphila (A. muciniphila) strains isolated from human stool samples and their relationship gut microbiota were evaluated using a high fat-diet (HFD)-fed mice model. Three A. chosen 27 isolates selected based on anti-lipogenic activity in 3T3-L1 cells. anti-lipogenic, anti-adipogenic these three further HFD-induced obese mice. animals...
Ethyl pyruvate (EP), a simple aliphatic ester of pyruvic acid, has been shown to have antiinflammatory effects and confer protective in various pathological conditions. Recently, number studies reported EP inhibits high mobility group box 1 (HMGB1) secretion suggest this might contribute its effect. Since is used calcium-containing balanced salt solution (Ringer solution), we wondered if directly chelates Ca2+ it related the EP-mediated suppression HMGB1 release. Calcium imaging assays...
Akkermansia muciniphila (A. muciniphila) is a promising probiotic candidate owing to its health-promoting properties. A previous study reported that the pasteurized form of A. strains isolated from human stool samples had beneficial impact on high-fat diet-induced obese mice. On other hand, differences in effects between live and metabolism immune system host are still inconclusive. This examines forms lipid glucose regulating inflammatory responses using HFD-fed mouse model. The animals...
Abstract Atopic dermatitis (AD) is a common inflammatory skin disease, and its pathogenesis closely associated with microbial homeostasis in the gut, namely gut-skin axis. Particularly, recent metagenomics studies revealed that abundance of two major bacterial species Faecalibacterium prausnitzii Akkermansia muciniphila , may play critical role AD, but effect these AD has not yet been elucidated. To evaluate potential beneficial F. or A. we conducted an animal model study where EB-FPDK11...
Introduction Obesity and related metabolic issues are a growing global health concern. Recently, the discovery of new probiotics with anti-obesity properties has gained interest. Methods In this study, four Faecalibacte-rium prausnitzii strains were isolated from healthy human feces evaluated on high-fat diet-induced mouse model for 12 weeks. Results The F. reduced body weight gain, liver fat weights, calorie intake while improving lipid glucose metabolism in adipose tissue, as evidenced by...
Atopic dermatitis (AD) is characterized by chronic inflammation of the skin. AD develops mainly in infants and young children. It induces skin disorders signals initiation allergic march including asthma rhinitis. Probiotics modify intestinal microbial populations a beneficial way for human animal hosts reducing inflammatory cytokines.As result their immunomodulatory properties, probiotics have been considered promising therapeutic option prevention treatment AD.In this study, we examined...
Muscular atrophy is a muscle disease in which mass and strength decrease due to aging, injury, metabolic disorders, or chronic conditions. Proteins tissue are degraded by the ubiquitin-proteasome pathway, accelerates this pathway. Akkermansia muciniphila Faecalibacterium prausnitzii strains effective agents against inflammatory diseases next-generation probiotic research. In study, we evaluated efficacy of A. strain EB-AMDK19 F. EB-FPDK11 mouse model muscular atrophy, since inhibits energy...
Human bone marrow‑derived mesenchymal stem cells (hMSCs) are a desirable cell source for cell‑based therapy to treat nervous system injuries due their ability differentiate into specific types. In addition multipotency, hMSCs render the tissue microenvironment more favorable repair by secreting various growth factors. Our previous study demonstrated that secrete several factors, including insulin‑like factor binding proteins (IGFBPs). Among these, IGFBP‑6 binds with high affinity and...
Cell proliferation is tightly controlled by the cell-cycle regulatory proteins, primarily cyclins and cyclin-dependent kinases (CDKs) in G1 phase. The ankyrin repeat-rich membrane spanning (ARMS) scaffold protein, also known as kinase D-interacting substrate of 220 kDa (Kidins 220), has been previously identified a prominent downstream target neurotrophin ephrin receptors. Many studies have reported that ARMS/Kidins220 acts major signaling platform organizing complex to regulate various...
Cerebral ischemia leads to brain injury via a complex series of pathophysiological events. Therefore, multidrug treatments or multitargeting drug are attractive options in efficiently limiting damage. Here, we report novel multifunctional compound oxopropanoyloxy benzoic acid (OBA-09), simple ester pyruvate and salicylic acid. This protective effect was manifested by recoveries from neurological behavioral deficits. OBA-09 exhibited antioxidative effects the postischemic brain, which...