A5048396851- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Dental Radiography and Imaging
- Orthodontics and Dentofacial Orthopedics
- Dental Erosion and Treatment
- Temporomandibular Joint Disorders
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- dental development and anomalies
- Autophagy in Disease and Therapy
- Dental Anxiety and Anesthesia Techniques
- Endodontics and Root Canal Treatments
- Multiferroics and related materials
- Ferroelectric and Piezoelectric Materials
- Oropharyngeal Anatomy and Pathologies
- Healthcare and Venom Research
- Advanced Drug Delivery Systems
- Additive Manufacturing and 3D Printing Technologies
- Oral and Maxillofacial Pathology
- Facial Rejuvenation and Surgery Techniques
- Biochemical Analysis and Sensing Techniques
- Flavonoids in Medical Research
- Mesenchymal stem cell research
- Dental Research and COVID-19
- Cell death mechanisms and regulation
Seoul National University
2016-2025
Seoul National University Dental Hospital
2011-2025
Kongju National University
2007-2025
University of Ulsan
2018-2023
Chungbuk National University
2021
Samsung (South Korea)
2015
National Institute of Fisheries Science
2014
Jeju National University
2014
University of Florida
2014
Yonsei University
2014
Activation of AMP-activated protein kinase (AMPK), a physiological cellular energy sensor, strongly suppresses cell proliferation in both nonmalignant and tumor cells. This study demonstrates the mechanism quercetin-induced apoptosis HT-29 colon cancer Treatment cells with quercetin significantly decreased viability dose-dependent manner. Notably, increased cycle arrest G1 phase up-regulated apoptosis-related proteins, such as AMPK, p53, p21, within 48 h. Furthermore, vivo experiments showed...
Augmentation reality technology offers virtual information in addition to that of the real environment and thus opens new possibilities various fields. The medical applications augmentation are generally concentrated on surgery types, including neurosurgery, laparoscopic plastic surgery. is also widely used education training. In dentistry, oral maxillofacial primary area use, where dental implant placement orthognathic most frequent applications. Recent technological advancements enabling...
With the advent of 3D printing technologies in dentistry, optimization conditions has been great interest, so this study analyzed accuracy 3D-printed temporary restorations different sizes produced by digital light processing (DLP) and liquid crystal display (LCD) printers. Temporary 2-unit, 3-unit, 5-unit, 6-unit, full-arch cases were designed printed from a DLP printer using NextDent C&B or an LCD Mazic D Temp (n = 10 each). The scanned, each restoration standard tessellation language...
Myricetin, a flavonoid found in fruits and vegetables, is known to have antioxidant anticancer effects. However, the effects of myricetin on SK‑BR‑3 human breast cancer cells not been elucidated. In present study, were confirmed cells. As concentration increased, cell viability decreased. DAPI (4',6‑diamidino‑2‑phenylindole) Annexin V/PI staining also revealed significant increase apoptotic bodies apoptosis. Western blot analysis was performed confirm myricetin‑induced expression...
Platycodin D (PD) is the main component of triterpene saponins found in Platycodi radix. In this study, we observed a decrease cell viability, an increase apoptotic bodies, and rate apoptosis. Also, cleaved PARP Bax, Bcl-2, p-ERK, p-p38 p-JNK. Furthermore, change viability expression p-p38, Bcl-2 using p38 inhibitor revealed Bax treatment group. addition, vacuole formation through morphological changes acidic vesicular organelles (AVOs). We also beclin 1, LC 3-I, -II. There was no...
The cysteine challenge test is a reliable and efficient method for halitosis diagnosis assessing treatment effectiveness by measuring the capacity to produce hydrogen sulfide. However, several aspects related including evaluation timing total duration following loading has not been investigated in-depth standardized protocol yet be established. This observational study compared concentrations of volatile sulfur compounds (VSCs) at various time points based on different measurement tools...
Apigenin, an aromatic compound, exhibits antioxidant, anti‑inflammatory and anti‑viral effects. The present study aimed to investigate the effects of apigenin on cell proliferation apoptosis human melanoma cells A375P A375SM. Therefore, were treated with determine its anti‑proliferative survival effects, using wound healing MTT assays. results revealed that viability was decreased in a dose‑dependent manner. Furthermore, chromatin condensation, indicating apoptosis, significantly increased...
Abstract: Microtomographic techniques are widely used for studying the trabecular architectures in orthopedics and elucidation of tooth micromorphology field dentistry. Its application to assess osseointegration dental implants has been studied as a non‐invasive method, contrary several conventional methods. The aim this study is evaluate possibility microtomography tool assessing osseointegration. Twenty‐four titanium (3.75 mm diameter 7 total length) were installed tibia New Zealand white...
The aim of this study was to evaluate and compare the osseointegration powder-injection molded (PIM) zirconia implants in rabbit tibiae with or without He plasma treatment.Twenty-five rabbits received 4 types external hex identical geometry tibiae: PIM implants, roughened plasma-treated implants. contact angles four were evaluated. Removal torque tests histomorphometric analyses performed.The treatment markedly enhanced hydrophilicity, but did not seem change surface topography There...
Abstract Objective To evaluate osseointegration in rabbit tibiae and to investigate surface characteristics of novel zirconia implants made by powder injection molding ( PIM ) technique, using molds with without roughened inner surfaces. Material methods A total 20 rabbits received three types external hex identical geometry on the tibiae: machined titanium implants, mold etching, etching. Surface implant were evaluated. Removal torque tests histomorphometric analyses performed. Results The...
Abstract Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, are fabricated with ridges (0.35−7 µm) grooves (0.65−6 various widths explored their mechanisms in improving differentiation. This study finds a pattern enhancing associated ability extend its length it able overcome inhibition takes place under inflammatory conditions. The...
The relative dentin abrasivity-profilometry equivalent values were compared using non-contact profilometry with three subtypes of regular toothpaste and two whitening containing sodium bicarbonate 35% hydrogen peroxide. Bovine specimens assigned to six groups: (R): R1 (BAMBOO SALT GUM OINTMENT); R2 (MEDIAN TARTAR ORIGINAL); R3 (PERIOE Alpha), Reference slurry: RS (calcium pyrophosphate), (W): W1 (NET. WT); W2 (Vussen 28 WHITENING). Relative abrasion-profilometry (RDA-PE) was determined by...
Cell replacement using stem cells is a promising therapeutic approach to treat degenerative motor neuron (MN) disorders, such as amyotrophic lateral sclerosis and spinal cord injury. Human bone marrow-derived mesenchymal (hMSCs) are desirable cell source for autologous therapy nervous system injury due their plasticity, low immunogenicity, lower risk of tumor formation than embryonic cells. However, hMSCs inefficient with regards differentiating into MN-like To solve this limitation, we...
Comparison of treatment effects between the modified C-palatal plate and cervical pull headgear for total arch distalization in adults Objective: The purpose this study was to evaluate dental skeletal (MCPP) adult patients with Class II malocclusion compare findings those headgear.Methods: sample consisted lateral cephalograms 44 Division 1 malocclusion, including 22 who received MCPP (age, 24.7 ± 7.7 years) 23.0 years).Pre-(T1) post-treatment (T2) were analyzed 24 linear angular...
The aim of this study was to evaluate and compare the osseointegration in rabbit tibiae smooth roughened powder injection moulded (PIM) zirconia implants with or without (Ti,Zr)O2 surface coatings.Twenty-five rabbits received four types external hex identical geometry on tibiae: PIM implants, -coated implants. characteristics were evaluated. Removal torque tests histomorphometric analyses performed.The coatings substantially changed topography chemical composition both type There...
The aim of this study was to suggest a clinical guideline properly position immediate implant placement in the anterior maxillary area.The computed tomography (CT) records 250 patients (125 males, 125 females; mean age 49.5 years) were evaluated, and relationship sagittal root positions central incisor teeth their respective alveolar bony housing classified as buccal (B), medial (M), or palatal (P). Then, suggested based on implications derived from classification. In second investigation,...