A5101714140- Phase Equilibria and Thermodynamics
- Mesenchymal stem cell research
- Chemical Thermodynamics and Molecular Structure
- Energy Harvesting in Wireless Networks
- Innovative Energy Harvesting Technologies
- Wireless Power Transfer Systems
- Tissue Engineering and Regenerative Medicine
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Subcritical and Supercritical Water Processes
- IL-33, ST2, and ILC Pathways
- Lysosomal Storage Disorders Research
- Thermodynamic properties of mixtures
- Catalysis and Oxidation Reactions
- Pluripotent Stem Cells Research
- Virus-based gene therapy research
- Dental Implant Techniques and Outcomes
- Dermatology and Skin Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Carbon dioxide utilization in catalysis
- Ionic liquids properties and applications
- Graphene and Nanomaterials Applications
- Thermal and Kinetic Analysis
- Cytomegalovirus and herpesvirus research
National Heart Lung and Blood Institute
2020-2024
National Institutes of Health
2020-2024
Sookmyung Women's University
2023-2024
Dankook University
2023
Seoul National University
2012-2021
University of Ulsan
2011-2015
Hallym University
1999-2014
Hannam University
2009-2011
Korea Center for Disease Control and Prevention
2010
Korea Disease Control and Prevention Agency
2010
While graphene and its derivatives have been suggested as a potential nanomedicine in several biomimetic models, their specific roles immunological disorders still remain elusive. Graphene quantum dots (GQDs) may be suitable for treating intestinal bowel diseases (IBDs) because of low toxicity vivo ease clearance. Here, GQDs are intraperitoneally injected to dextran sulfate sodium (DSS)-induced chronic acute colitis model, efficacy has confirmed. In particular, effectively prevent tissue...
Abstract Mesenchymal stem cells (MSCs) possess unique immunomodulatory abilities. Many studies have elucidated the clinical efficacy and underlying mechanisms of MSCs in immune disorders. Although immunoregulatory factors, such as Prostaglandin E 2 (PGE ) their action on been revealed, effects regulation production by culture environment are less clear. Therefore, we investigated autocrine effect PGE human adult from cord blood or adipose tissue its cell-to-cell contact, followed...
Abstract With the rapidly growing demand for mesenchymal stem cell (MSC) therapy, numerous strategies using MSCs different diseases have been studied and reported. Because of their immunosuppressive properties, are commonly used as an allogeneic treatment. However, many donors who could potentially be used, it is important to understand capacity therapeutic usage with donor-to-donor heterogeneity. In this study, we aimed investigate a promising strategy critical limb ischemia. We evaluated...
Mesenchymal stem cell (MSC) has been applied for the therapy of allergic disorders due to its beneficial immunomodulatory abilities. However, underlying mechanisms therapeutic efficacy are reported be diverse according source isolation or route administration. We sought investigate safety and human adipose tissue-derived MSCs (hAT-MSCs) in mouse atopic dermatitis (AD) model determine distribution cells after intravenous Murine AD was established by multiple treatment Dermatophagoides...
Because human mesenchymal stem cells (hMSC) have profound immunomodulatory effects, many attempts been made to use hMSCs in preclinical and clinical trials. For be used therapy, a large population of must generated by vitro expansion. However, the changes following expansion not elucidated. In this study, we evaluated effect replicative senescence on ability vivo. Late-passage showed impaired suppressive mitogen-induced mononuclear cell proliferation. Strikingly, late-passage had...
The aim of this in vitro study was to investigate the adhesion initial colonizer, Streptococcus sanguis, on resin, titanium and zirconia under same surface polishing condition.MATERIALS AND METHODS.Specimens were prepared from Z-250, cp-Ti 3Y-TZP polished with 1 μ m diamond paste.After coating saliva, each specimen incubated sanguis.Scanning electron microscope, crystal violet staining measurement fluorescence intensity resulting resazurin reduction performed for quantifying bacterial...
Although human mesenchymal stem cells (hMSCs) hold considerable promise as an alternative therapeutic reagent for allergic disorders including atopic dermatitis (AD), the strategy enhancing hMSC-based therapy remains challenging.We sought to investigate whether preconditioning with mast cell (MC) granules could enhance efficiency of umbilical cord blood-derived MSCs (hUCB-MSCs) against AD.Methods: AD was experimentally induced in NC/Nga mice by repeated applications 4% sodium dodecyl sulfate...
Abstract A new group‐contribution lattice–fluid equation of state (GCLF‐EOS), which is capable predicting the equilibrium properties polymer–solvent solutions, was developed by modifying original GCLF‐EOS High and Danner. The a form Panayiotou–Vera based on lattice‐hole theory. Group contributions for interaction energy reference volume were only saturated vapor pressure liquid densities low molecular weight compounds. For mixture, binary parameter introduced into mixing rules. from...
This paper describes a low frequency driven electromagnetic energy harvester (EMEH) for self-powered system. The EMEH consists of two thin flame resistant (FR-4) springs, NdFeB permanent magnets, and copper coil. FR-4 spring was fabricated by desk computer numerical control (CNC) 3D modeling machine. springs were used at the top bottom sides device to reduce stress on achieve linear movement moving magnet. finite element method (FEM) is investigate mechanical properties proposed can generate...
Microglia can aggravate olfactory dysfunction by mediating neuronal death in the bulb (OB) of a murine model Niemann-Pick disease type C1 (NPC1), fatal neurodegenerative disorder accompanied lipid trafficking defects. In this study, we focused on crosstalk between neurons and microglia to elucidate mechanisms underlying extensive microgliosis NPC1-affected brain. OB NPC1 mice strongly expressed CX3C chemokine receptor 1 (Cx3cr1), specific for neural C-X3-C motif ligand (Cx3cl1). addition,...
DNA methyltransferase (DNMT) inhibitors regulate target gene expression through epigenetic modifications and these compounds have primarily been studied for cancer therapy or reprogramming. However, the effect of DNMT on immunomodulatory capacity human mesenchymal stem cells (hMSCs) has not investigated. In present study, we treated hMSCs with 5-azacytidine (5-aza), a inhibitor confirmed that inhibitory effects mononuclear cell proliferation migration toward activated T were increased. To...
Defects in the nuclear lamina occur during physiological aging and as a result of premature disorders. Aging is also accompanied by an increase transcription genes encoding cytokines chemokines, phenomenon known senescence-associated secretory phenotype (SASP). Progerin prelamin A trigger senescence loss function human mesenchymal stem cells (hMSCs), but little about how defects lamin regulate SASP. Here, we show that both progerin overexpression ZMPSTE24 depletion induce paracrine...
A supercritical antisolvent (SAS) process was used to prepare micronized cyclotrimethylenetrinitramin (RDX). This study examined the influence of different solvents at a fixed temperature (50 °C) and pressure (13.7 or 15 MPa) on morphology, particle size (PS), distribution (PSD) using semicontinuous SAS process. Dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetone (AC), acetonitrile (ACN), n-methyl 2-pyrrolidone (NMP), cyclohexanone (CHN) were as solvents. The recrystallized RDX...
For the application of mesenchymal stem cells (MSCs) as clinical therapeutics, regulation cellular aging is important to protect hMSCs from an age-associated decline in their function. In this study, we evaluated effects hypoxia on senescence and immunomodulatory abilities hUCB-MSCs. Hypoxic-cultured hUCB-MSCs showed enhanced proliferation had increased immunosuppressive mitogen-induced mononuclear cell proliferation. We found that BMI1, a member polycomb repressive complex protein group,...
Niemann-Pick disease type C (NPC) is a neurodegenerative and lysosomal lipid storage disorder, characterized by the abnormal accumulation of unesterified cholesterol glycolipids, which caused mutations in NPC1 genes. Here, we report generation human induced neural stem cells from NPC patient-derived fibroblasts (NPC-iNSCs) using only two reprogramming factors SOX2 HMGA2 without going through pluripotent state. NPC-iNSCs were stably expandable differentiated into neurons, astrocytes,...
Although the generation of ETV2-induced endothelial cells (iECs) from human fibroblasts serves as a novel therapeutic strategy in regenerative medicine, process is inefficient, resulting incomplete iEC angiogenesis. Therefore, we employed chromatin immunoprecipitation (ChIP) sequencing and identified molecular mechanisms underlying ETV2-mediated transdifferentiation to efficiently produce iECs retaining appropriate functionality long-term culture. We revealed that majority ETV2 targets are...