Acute pneumonia is an inflammatory disease caused by several pathogens, with symptoms such as fever and chest pain, to which children are particularly vulnerable. Gancaonin N a prenylated isoflavone of Glycyrrhiza uralensis that has been used in the treatment various diseases oriental medicine. There little data on anti-inflammatory efficacy N, its effects mechanisms acute unknown. Therefore, this study was conducted preliminary analysis effect lipopolysaccharide (LPS)-induced RAW264.7...

Obesity is a serious global health challenge, closely associated with numerous chronic conditions including type 2 diabetes. Anemarrhena asphodeloides Bunge (AA) known as Jimo has been used to address pathogenic heat such wasting-thirst in Korean Medicine. Timosaponin A3 (TA3), natural compound extracted from AA, demonstrated potential therapeutic effects various disease models. However, its on diabetes and obesity remain largely unexplored. We investigated the anti-obesity anti-diabetic...

Obesity is a risk factor for metabolic diseases including type 2 diabetes, nonalcoholic steatohepatitis (NASH), heart diseases, and cancer. This study aimed to investigate the anti-obesity effect of Polygalin C (PC) isolated from Polygala japonica Houtt. in 3T3-L1 adipocytes. Based on Oil Red O assay results, PC significantly decreased lipid accumulation compared control. We found that suppressed adipogenesis transcription factors peroxisome proliferator-activated receptor γ (PPAR γ)...

This study investigated the effects of Lycium chinense Mill (LCM) extract on obesity and diabetes, using both in vitro high-fat diet (HFD)-induced mouse models. We found that LCM notably enhanced glucagon-like peptide-1 (GLP-1) secretion NCI-h716 cells from 411.4 ± 10.75 pg/mL to compared NT (78.0 0.67 pg/mL) without causing cytotoxicity, implying involvement Protein Kinase A C (PKA C) AMP-activated protein kinase (AMPK) its action mechanism. also decreased lipid droplets lowered expression...

Timosaponin A3 (TA3) was demonstrated as a potent anticancer chemical by several studies. Although the effects of inhibiting growth, metastasis, and angiogenesis in various cancer cells were through multiple mechanisms, pharmacological mechanism TA3 shown pancreatic (PC) is insufficient compared to other cancers. In this study, we aimed explore key molecular mechanisms underlying growth inhibitory using PC xenograft model. First, from microarray results, found that regulated INSIG-1 HMGCR...

Bitter taste receptors (TAS2Rs) are G protein-coupled localized in the buds of tongue. They may also be present non-lingual organs, including brain, lung, kidney, and gastrointestinal (GI) tract. Recent studies on bitter receptor functions have suggested TAS2Rs as potential therapeutic targets. The human subtype hTAS2R50 responds to its agonist isosinensetin (ISS). Here, we demonstrated that, unlike other TAS2R agonists, activated well increased Glucagon-like peptide 1 (GLP-1) secretion...

In this study, we investigated the potential anticancer effects of Viscum album, a parasitic plant that grows on Malus domestica (VaM) breast cancer cells, and explored underlying mechanisms. VaM significantly inhibited cell viability proliferation induced apoptosis in dose-dependent manner. also regulated cycle progression effectively activation STAT3 signaling pathway through SHP-1. Combining with low-dose doxorubicin produced synergistic effect, highlighting its as promising therapeutic....

Ophiopogonin D (OP-D), which is extracted from the root tuber of Ophiopogon japonicus , well known for its anti-inflammatory, anti-oxidant, and anti-cancer effects. It also therapeutic various diseases such as diabetic myocardial injuries, obesity, atopic dermatitis, osteoporosis. However, there are insufficient reports on effects molecular mechanisms OP-D in colorectal cancer. Therefore, this study aimed to investigate anti-cancer-modulating effect The proved that (20–40 uM) has significant...

Colorectal cancer cell (CRC) is the fourth most common in world. There are several chemotherapy drugs available for its treatment, though they have side effects. Cycloastragenol (CY) a compound from Astragalus membranaceus (Fisch.) Bge known to be effective aging, anti-inflammatory, anticancer, and anti-heart failure treatments. Although many studies demonstrated functions of CY cells, no shown effects p53 colon cells. In this study, we found that reduces viability cells wild-type compared...

Colorectal cancer (CRC) is the third most commonly diagnosed worldwide, and despite advances in treatment, survival rates are still low; therefore, development of novel drugs imperative. Acetylcorynoline (ACN) derived from Corydalis ambigua Cham. et Schltdl tubers. The effect ACN on colon unknown. Therefore, we investigated its potential effects. Our data showed that inhibited cell viability proliferation. Moreover, induced apoptosis cycle arrest by inhibiting growth. In present study,...

Inflammation causes a protective immune response, which can be observed by examining the inflammatory responses of macrophages. Macrophages release various immunostimulatory factors when destroying external pathogens. We induced lipopolysaccharides (LPS) in RAW 264.7 cells, macrophage cell line, to determine whether Helixor-M cause immuno-suppression. is known have anticancer and effects. However, an indicator that regulates immunity has not been clearly confirmed. To this end,...

Pancreatic cancer(PC) is less common than other cancers; however, it has a poor prognosis. Therefore, studying novel target signaling and anticancer agents necessary. Momordicae Semen (MS), the seed of Momordica sochinensis Spreng, mainly found in South-East Asia, including China Bangladesh, used to treat various diseases because its anticancer, antioxidant, anti-inflammatory, antibacterial properties. However, effect MS extract on pancreatic cancer cells remains unknown. In this study...

Timosaponin A3 (TA3), extracted from the rhizome of Anemarrhenaasphodeloides Bunge, has been reported to affect various diseases, such as cancer, Alzheimer's disease, and allergies. However, underlying molecular mechanisms impacts are largely unknown. In present study, we hypothesized that TA3 induces apoptosis through inhibition c-Myc expression via CNOT2 or MID1IP1 in HCT116. An MTT assay colony formation were used measure cell viability proliferation. The protein apoptotic markers...

We hypothesized that Euonymus sachalinensis (ES) induces apoptosis by inhibiting the expression of c-Myc in colon cancer cells, and this study proved methanol extract ES has anticancer effects cells. belongs to Celastraceae family is well known for its medicinal properties. Extracts species belonging have been used treat diverse diseases, including rheumatoid arthritis, chronic nephritis, allergic conjunctivitis, rhinitis, asthma. However, targeted because there are currently few studies on...

Colorectal cancer (CRC) is the third most commonly diagnosed worldwide, and despite advances in treatment, survival rates are still low; therefore, development of novel drugs imperative. Acetylcorynoline (ACN) derived from Corydalis ambigua. The effect ACN on colon unknown. Therefore, we investigated its potential effects. Our data showed that inhibited cell viability proliferation. Moreover, induced apoptosis cycle arrest by inhibiting growth. In present study, hypothesized regulates c-Myc...

Exposure to water-soluble particulate matter (WPM) containing heavy metals can cause severe inflammatory responses and trigger exacerbate the onset of asthma. As a follow-up study Rosa laevigata (RL), this analyzed therapeutic effects mechanisms oral intratracheal administration RL demonstrated anti-inflammatory in asthma models. Worse T-helper cell type 2 (Th2)-related pro-inflammatory were observed after simultaneous challenge with ovalbumin (OVA) WPM. To establish model exacerbated by...

Abstract Otopetrin 3 (OTOP3) stands out as a pivotal regulator of intracellular pH through its control over proton transportation into cells, affecting fundamental cellular processes. Previous studies have shown that OTOP3 is associated with the prognosis colorectal cancer (CRC) patients. However, mechanism underlying regulation remains unclear in cancer. Our investigation reveals potent oncogene CRC, higher levels correlating diminished overall survival rates CRC Comparative analysis...

Abstract Extracted from the root tuber of Ophiopogon japonicas, ophiopogon is well known to have an anti-cancer effect. However, underlying mechanisms are still largely unknown. Here, we report that D (OP-D) can inhibit colon cancer cell proliferation and induce apoptosis by inhibiting c-Myc expression through activation p53 CNOT2 regulation. Our results showed OP-D induced via ribosomal protein L5 or L11 inhibited in a dose-dependent manner. Additionally, regulated cyclin D1 CDK4 which as...