A5024349222- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Ion Transport and Channel Regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- ATP Synthase and ATPases Research
- Lymphoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
- Chronic Myeloid Leukemia Treatments
- Advanced Breast Cancer Therapies
- Ion channel regulation and function
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Cardiovascular Issues in Pregnancy
Emory University
2024-2025
Dongguk University
2025
Novartis (United States)
2020-2024
Cancer Institute (WIA)
2024
Boston Biomedical Research Institute
2023
Johns Hopkins University
2006-2022
University of Washington
2006-2021
Harvard University
2011-2020
Dana-Farber Cancer Institute
2011-2020
Fred Hutch Cancer Center
2015-2019
The aquaporins (AQP) are water channel proteins playing a major role in transcellular and transepithelial movement. Recently, the of AQPs human carcinogenesis has become an area great interest. Here, by immunohistochemistry (IHC), we have found expression AQP5 protein 35.3% (IHC-score: ≥1, 144/408) resected NSCLC tissue samples. Cases with AQP5-positive status ≥2) displayed higher rate tumor recurrence than negative ones (54.7% vs. 35.1%, p = 0.005) worse disease-free survival (p 0.033; OR...
Insomnia impairs daily functioning and increases health risks. Cognitive behavioral therapy for insomnia (CBT-I) is effective but limited by cost therapist availability. Fully automated digital CBT-I (FA dCBT-I) provides an accessible alternative without involvement. This systematic review meta-analysis evaluated the effectiveness of FA dCBT-I across 29 randomized controlled trials (RCTs) involving 9475 participants. Compared to control groups, demonstrated moderate large effects on...
Canakinumab, a monoclonal antibody targeting proinflammatory cytokine interleukin-1β (IL-1β), improved hemoglobin levels while preventing recurrent cardiovascular events in the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). This (CV) preventive effect was greater patients with TET2 mutations associated clonal hematopoiesis (CH). The current proteogenomic analysis aimed to understand clinical response canakinumab and underlying proteomic profiles context of CH anemia....
Aquaporins (AQPs) have previously been associated with increased expression in solid tumors. However, its hematologic malignancies including CML has not described yet. Here, we report the of AQP5 cells by RT-PCR and immunohistochemistry. While normal bone marrow biopsy samples (n = 5) showed no AQP5, 32% patient 41) demonstrated expression. In addition, level emergence imatinib mesylate resistance paired (p 0.047). We found that overexpression K562 resulted cell proliferation. small...
Mesenchymal cells underlying the definitive endoderm in vertebrate animals play a vital role digestive and respiratory organogenesis. Although several signaling pathways are implicated foregut patterning morphogenesis, despite clinical importance of congenital tracheal esophageal malformations humans, understanding molecular mechanisms that allow single tube to separate correctly into trachea esophagus is incomplete. The homoebox gene Barx1 highly expressed prospective stomach mesenchyme...
Highlights•The components of the DIPPS plus classification have prognostic relevance after adjustment by DIPSS classification.•Higher risk is associated with inferior survival and higher both relapse treatment-related mortality.AbstractHematopoietic cell transplantation (HCT) provides potentially curative treatment for patients myelofibrosis (MF). HCT outcomes are Dynamic International Prognostic Scoring System (DIPSS) scores. In present study we analyzed results in 233 to determine if...
Abstract Aberrant innate immune signaling has been identified as a potential key driver of the complex pathophysiology myelodysplastic neoplasms (MDS). This study large, clinically and genetically well-characterized cohort treatment-naïve MDS patients confirms intrinsic activation inflammatory pathways in general mediated by caspase-1, interleukin (IL)-1β IL-18 low-risk (LR)-MDS bone marrow reveals previously unrecognized heterogeneity inflammation between defined LR-MDS subgroups. Principal...
Abstract Clonal hematopoiesis (CH) is more common in older persons and has been associated with an increased risk of hematological cancers cardiovascular diseases. The most CH mutations occur the DNMT3A TET2 genes result proinflammatory signaling. Canakinumab Anti-inflammatory Thrombosis Outcome Study (NCT01327846) evaluated neutralizing anti-IL1β antibody canakinumab 10,061 randomized patients a history myocardial infarction persistent inflammation; DNA samples were available from 3,923 for...
Retrospective analyses suggest a benefit of therapy with hypomethylating agents in patients myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who relapse after allogeneic hematopoietic cell transplantation (HCT). We conducted prospective trial 39 MDS AML relapsed within 100 days HCT. Relapse was documented by morphology, flow cytometry, cytogenetics. Treatment consisted 5-azacitidine, 75 mg/m
Abstract Venetoclax (VEN), in combination with hypomethylating agents (HMAs) such as azacitidine or decitabine, is a widely used treatment for AML patients, yet the molecular biomarkers contributing to sensitivity VEN+HMA regimen remain incompletely elucidated, particularly regard role of BCL2-family proteins. In this study, we retrospectively collected BMMCs PBMCs from patients prior initiation therapy at Winship Cancer Institute Emory University. A total 47 specimens were analyzed,...
Chronic myelomonocytic leukemia (CMML) is a heterogeneous group of clonal hematopoietic malignancies with variable clinical and molecular features. We analyzed long-term results allogeneic cell transplantation in patients CMML determined risk factors associated outcomes. Data from 129 patients, aged 7-74 (median 55) years, at various stages the disease transplanted related or unrelated donors were analyzed. Using panel 75 genes somatic mutations present before identified In 52 patients. The...
Although microRNAs (miRNAs) are postulated to fine-tune many developmental processes, their relationships with specific targets and tissues remain largely undefined. The mesenchymal transcription factor Barx1 controls spleen stomach morphogenesis is required specify stomach-specific epithelium in adjacent endoderm. expression precisely regulated space time, a sharp drop levels after epithelial specification. We tested the hypothesis that miRNAs mediate this marked decline levels. Depletion...
Gastroesophageal cancer is a significant global problem that frequently presents at an incurable stage and has very poor survival with standard chemotherapy approaches. This review will examine the epidemiology molecular biology of gastroesophageal focus on key deregulated signaling pathways have been targeted in clinic. A comprehensive overview clinical data highlighting successes failures agents be presented. Most notably, HER2-targeted therapy monoclonal antibody trastuzumab proven...