A5050864453- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Congenital Heart Disease Studies
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Diabetes Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Genetic Associations and Epidemiology
- Innovations in Medical Education
- Cardiovascular Health and Disease Prevention
- Cardiovascular Issues in Pregnancy
- Acute Myocardial Infarction Research
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
Seoul National University Bundang Hospital
2008-2024
New Generation University College
2016-2024
Scripps Institution of Oceanography
2023
Scripps Research Institute
2023
S.P.E.C.I.E.S.
2022
Weatherford College
2020
Chungnam National University Hospital
2020
Taichung Veterans General Hospital
2019
AimsMaximal hyperaemia is a key element of invasive physiological studies and adenosine the most commonly used agent. However, infusion requires additional venous access can cause chest discomfort, bronchial hyper-reactivity, atrioventricular conduction block. The aim this study was to evaluate feasibility efficacy intracoronary (IC) nicorandil as novel hyperaemic agent for studies.
To assess the distribution of pressure and shear-related forces acting on atherosclerotic plaques their association with lesion characteristics using coronary CT angiography (cCTA)-based computational fluid dynamics (CFD) model epicardial arteries.Patient-specific models arteries were reconstructed from cCTA in 80 patients (12 women, 63.8±9.0 years). The wall shear stress (WSS) left anterior descending assessed CFD. High-risk defined as presence at least one following adverse plaque...
Background: The echocardiographic assessment of left ventricular (LV) diastolic dysfunction (LVDD) in patients with hypertrophic cardiomyopathy is complex and not well-established. We investigated whether the atrial reservoir strain (LARS) could be used to categorize LVDD this grading predictive heart failure (HF) events cardiomyopathy. Methods: A total 414 (aged 58.3±12.8 years; 65.7% male) were categorized using LARS-defined (LARS-DD) grades: ≥35% (grade 0), ≥24% <35%, ≥19% <24%,...
Background Meta‐analyses of large clinical trials investigating SGLT2 (sodium‐glucose cotransporter‐2) inhibitors have suggested their protective effects against atrial fibrillation in patients with type 2 diabetes. However, the results were predominantly driven from involving dapagliflozin. Methods and Results We used a nationwide, population‐based cohort diabetes who initiated either dapagliflozin or empagliflozin between May 2016 December 2018. An active‐comparator, new‐user design was...
The association between alkaline phosphatase (ALP) and mortality was reported in several subgroups of patients. But, the role ALP overall coronary artery disease (CAD) patients after percutaneous intervention (PCI) remains unknown. aim this study to examine prognostic value level with CAD who underwent PCI drug-eluting stent (DES). We prospectively included DES. After exclusion liver cancer, 1636 were selected for analysis clinical outcomes (median duration follow-up; 762 days,...
We aimed to investigate whether long-term exposure particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) in the ambient air is related development or growth of coronary plaques.This study involved 364 residents Seoul, Korea, who underwent serial computed tomographic angiography (CCTA) at interval ≥2 years. Each participant's average concentration residential PM2.5 between two CCTAs was calculated. Primary endpoint high-risk plaque (HRP), defined as a low attenuation, spotty...
Abstract Aims Left atrial (LA) dysfunction can be associated with left ventricular (LV) disorders; however, its clinical significance has not been well-studied in patients acute heart failure (AHF). We evaluated prognostic power of peak longitudinal strain (PALS) the atrium according to (HF) phenotypes and fibrillation (AF). Methods results From an AHF registry 4312 patients, we analysed PALS 3818 patients. Patients were categorized into tertiles. also divided HF [HF reduced ejection...
In large-scale genomic studies, Sox17, an endothelial-specific transcription factor, has been suggested as a putative causal gene of pulmonary arterial hypertension (PAH); however, its role and molecular mechanisms remain to be elucidated. We investigated the functional impacts acting impaired Sox17 (SRY-related HMG-box17) pathway in PAH explored potential therapeutic target.In adult mice, deletion endothelial cells (ECs) induced under hypoxia with high penetrance severity, but not...
Abstract Differential diagnosis of left ventricular hypertrophy (LVH) is often obscure on echocardiography and requires numerous additional tests. We aimed to develop a deep learning algorithm aid in the differentiation common etiologies LVH (i.e. hypertensive heart disease [HHD], hypertrophic cardiomyopathy [HCM], light-chain cardiac amyloidosis [ALCA]) echocardiographic images. Echocardiograms 5 standard views (parasternal long-axis, parasternal short-axis, apical 4-chamber, 2-chamber,...
Purpose To explore the prognostic value of cardiac magnetic resonance (MR) imaging in predicting postoperative death patients with severe functional tricuspid regurgitation (TR). Materials and Methods This study was approved by institutional review board, written informed consent obtained from all patients. Prospectively collected data included MR images, New York Heart Association (NYHA) class, a comprehensive laboratory test, clinical events over follow-up period 75 consecutive (61 women...
Temporal trends of the prevalence and incidence hypertrophic cardiomyopathy (HCM) have not been well established in Asian populations. Using Korean National Health Insurance Services database, we identified patients with a confirmed diagnosis HCM between 2010 2016. The annual HCM, their clinical characteristics were investigated. has increased from 0.016% (n = 6313) to 0.031% 13,035) During 7-year period, 13,229 newly diagnosed HCM. rate 4.15 (per 100,000 person-years) 5.6 age peaked during...
Abstract Background The effects of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on cardiac function are not fully understood. We investigated the changes in diabetic patients according to presence and types heart failure (HF). Methods retrospectively identified 202 who underwent echocardiography before, 6 24 months after initiation SGLT2i. After propensity score matching with without SGLT2i, study population (n = 304) were categorized into group 1 (without HF nor SGLT2i; n 76), received...