A5100324553- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Microscopic Colitis
- Ocular Diseases and Behçet’s Syndrome
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders
- Vasculitis and related conditions
- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Anorectal Disease Treatments and Outcomes
- Metastasis and carcinoma case studies
- Eosinophilic Esophagitis
Yonsei University
2016-2025
Severance Hospital
2012-2025
Seoul National University
1999-2025
Ewha Womans University
2025
University of Seoul
2025
Korea Advanced Institute of Science and Technology
2021-2024
Hospices Civils de Lyon
2024
University Health Network
2024
University of Pittsburgh
2010-2023
Pohang University of Science and Technology
2002-2023
Chemoradiotherapy and transplantation of bone marrow from matched sibling donors have been useful for the treatment acute lymphoblastic leukemia in patients with a poor prognosis but are not available to some two thirds who do allogeneic donor. We undertook this study compare autologous such cases. treated 91 high-dose chemoradiotherapy followed them 1.4 5 years. Forty-six an HLA-matched donor received marrow, 45 without their own taken during remission purged leukemic cells use monoclonal...
Toll-like receptor 9 (TLR9) senses microbial DNA and triggers type I IFN responses in plasmacytoid dendritic cells (pDCs). Previous studies suggest the presence of myeloid differentiation primary response gene 88 (MyD88)-dependent sensors other than TLR9 pDCs. Using MS, we investigated C-phosphate-G (CpG)-binding proteins from human pDCs, pDC-cell lines, interferon regulatory factor 7 (IRF7)-expressing B-cell lines. CpG-A selectively bound aspartate-glutamate-any amino...
Abstract 5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks tumor mass, recurrence after chemotherapy is barrier to effective clinical outcomes CRC patients. Here, we demonstrate that p53 promotes WNT3 transcription, leading activation of WNT/β-catenin pathway in Apc Min/+ /Lgr5 EGFP mice, patient-derived organoids (PDTOs) and cells (PDCs). Through this regulation, induces enrichment stem (CSCs) residual tumors, contributing...
The aims of this prospective study were to document the incidence colon immediate postpolypectomy bleeding (IPPB) according grade, and identify potential risk factors IPPB in patients who have received complete colonoscopy polypectomy because a colorectal polyp.This was prospective, cross-sectional 5,152 treated at 11 tertiary medical centers between July 2003 2004. Patient-related, polyp-related, procedure-related variables evaluated as for IPPB. defined occurring during procedure graded...
Functional magnetic resonance imaging (fMRI) in anesthetized rodents has been commonly performed with α-chloralose, which can be used only for terminal experiments. To develop a survival fMRI protocol, an isoflurane (ISO) -anesthetized rat model was systematically evaluated by simultaneous measurements of field potential (FP) and cerebral blood flow (CBF) the somatosensory cortex. A conventional forepaw stimulation paradigm 0.3 ms pulse width, 1.2 mA current, 3 Hz frequency induced 54% less...
Metformin use has been associated with decreased cancer risk and mortality. However, the effects of metformin on clinical outcomes colorectal (CRC) are not defined. This study aimed to evaluate association between mortality CRC in diabetic patients. We identified 595 patients who were diagnosed both diabetes mellitus. Patients compared by two groups; 258 taking 337 metformin. Patient's demographics, characteristics, overall CRC-specific analyzed. After a median follow-up 41 months, there 71...
Quantifying both arterial cerebral blood volume ( CBV a ) changes and total t during neural activation can provide critical information about vascular control mechanisms, help to identify the origins of neurovascular responses in conventional oxygenation level dependent (BOLD) magnetic resonance imaging (MRI). Cerebral flow CBF), , were quantified by MRI at 9.4T isoflurane-anesthetized rats 15-s duration forepaw stimulation. simultaneously determined modulation tissue vessel signals using...
Adenomatous polyposis coli ( APC ) loss-of-function mutations and K-Ras gain-of-function are common abnormalities that occur during the initiation intermediate adenoma stages of colorectal tumorigenesis, respectively. However, little is known about role these play in cancer stem cells (CSCs) associated with (CRC) tumorigenesis. We analyzed tissue from CRC patients (n = 49) to determine whether contributed CSC activation DLD-1-K-Ras-WT DLD-1-K-Ras-MT were cultured evaluated for their ability...
It is difficult to diagnose intestinal Behçet's disease (BD) due various extraintestinal manifestations emerging at different time points in the course and a lack of reliable diagnostic criteria. We conducted this study develop validate novel criteria for BD.Experts from three universities generated preliminary BD, consensus was reached using modified Delphi method with 13 gastroenterologists participating. To criteria, we recruited 12,850 consecutive patients who underwent colonoscopic...
<h3>Background and Aims</h3> To identify the associations of genetic epigenetic variations in <i>IL-23R</i> <i>IL-17A</i> with inflammatory bowel diseases (IBD). <h3>Methods</h3> The promoter exon regions were analysed 727 subjects (201 Crohn9s disease, 268 ulcerative colitis 258 healthy controls) using DNA sequencing denaturing high performance liquid chromatography. Transcription factor binding affinity, mRNA expression methylation evaluated peripheral blood mononuclear cells (PBMC) Jurkat...
Abstract WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-catenin mutations. Both processes promote nuclear accumulation, which up-regulates epithelial-to-mesenchymal transition (EMT). We investigated localization, transcriptome, and phenotypic differences of HCT116 cells containing a wild-type (HCT116-WT) mutant allele (HCT116-MT), parental with both WT alleles (HCT116-P). then analyzed expression associated phenotypes CRC tissues. Wild-type showed...
Abstract Interleukin 33 (IL-33) that signals through the ST2 receptor has emerged as a critical modulator in several inflammatory disorders, including bowel disease (IBD). However, precise mechanisms by which IL-33 modulates IBD are controversial. The aim of this study was thus to clarify role IBD. plasma levels were significantly decreased, but soluble increased patients with compared healthy individuals. Moreover, restored goblet cell numbers and induced macrophage switching from M1 M2...
Metformin has been known to suppress cancer stem cells (CSCs) in some cancers. However, the differential effects of metformin on CSCs and their mechanisms have not reported. Herein, induced pAMPK activation pS6 suppression metformin-sensitive (HT29) cells, but metformin-resistant (SW620) cells. The oxygen consumption rate was higher HT29 than SW620 showed a prominent decrease after treatment In glutamine-depleted medium, low-glucose became sensitive CSC-suppressing effect metformin. A...
The present study aimed to investigate whether the Janus‑activated kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is a critical mechanism underlying cancer‑associated fibroblast (CAF)‑induced chemoresistance gastric cancer (GC). In addition, tried suggest natural product compromise effects CAF on GC. results cell proliferation assay revealed that conditioned medium (CM) collected from CAFs further increased resistance 5‑fluorouracil (5‑FU) in GC...
Myeloid-derived suppressor cells (MDSCs) and M2 macrophages in the tumor microenvironment contribute to progression by inducing immune tolerance antigens cancer cells. Metformin, one of most common diabetes drugs, has shown anti-inflammatory anti-tumor effects. However, effects metformin on inflammatory its underlying mechanisms remain unclarified. In this study, we investigated effect MDSCs using monocyte THP-1 a dextran sodium sulfate (DSS)-treated ApcMin/+ mouse model colon cancer....
Colorectal cancer progresses through a well-defined adenoma–carcinoma sequence (ACS), which is pivotal for early detection and intervention. While ACS-based surveillance has been instrumental, its reliance on tissue sampling limits accurate staging. Liquid biopsies, including circulating tumor DNA (ctDNA) extracellular RNA, have emerged as non-invasive alternatives, yet they primarily detect genetic alterations or passive RNA release rather than active biological processes. Thus, there need...