A5100424891- Gastric Cancer Management and Outcomes
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Hepatitis B Virus Studies
- Ocular Diseases and Behçet’s Syndrome
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Mycobacterium research and diagnosis
- Diverticular Disease and Complications
- Nutrition and Health in Aging
- COVID-19 Clinical Research Studies
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Liver Disease and Transplantation
- Asthma and respiratory diseases
Seoul National University
2013-2025
Hanyang University
2025
Seoul National University Hospital
2010-2025
Pusan National University Yangsan Hospital
2016-2025
New Generation University College
2012-2024
Unifor
2024
Kyung Hee University Medical Center
2024
Virginia Commonwealth University
2024
University Health System
2024
Kyung Hee University
2024
Background and Aims: Inflammatory bowel disease (IBD) may be associated with anxiety depression. The aim of this study was to evaluate the incidence depression in patients IBD compared general population. Methods: A nationwide population-based cohort conducted using claims data from National Healthcare Insurance service Korea. We between 15,569 46,707 non-IBD controls, age sex matched at a ratio 1:3. Results: During mean follow-up six years, experienced significantly more (12.2% vs. 8.7%; p...
Metformin has been known to suppress cancer stem cells (CSCs) in some cancers. However, the differential effects of metformin on CSCs and their mechanisms have not reported. Herein, induced pAMPK activation pS6 suppression metformin-sensitive (HT29) cells, but metformin-resistant (SW620) cells. The oxygen consumption rate was higher HT29 than SW620 showed a prominent decrease after treatment In glutamine-depleted medium, low-glucose became sensitive CSC-suppressing effect metformin. A...
Background and Aims: It is not known whether inflammatory bowel disease (IBD) enhances the risk of Parkinson's (PD) or PD diagnosis result increased health care use. We determined developing among patients with IBD in terms medication Methods: A nationwide population-based study was conducted using claims data from Korean National Health Insurance service. From 2010 to 2013, Crohn's (CD) ulcerative colitis (UC) were identified through both International Classification Disease, Tenth Revision...
Throughout an individual's lifetime, genomic alterations accumulate in somatic cells
Although gastrointestinal endoscopy (GIE) is a major contributor to the carbon footprint of national healthcare, amount medical waste generated by GIE procedures not reported in South Korea. This study aimed measure from
Abstract We characterized 8 human hepatocellular‐carcinoma cell lines established from the primary tumors of Korean patients. All showed substrate adherence and one line anaplastic tumor also grew as floating aggregates. Most cultured cells maintained many morphological characteristics original which they were derived. Doubling times varied 34 to 72 hr. relatively high viability not contaminated with Mycoplasma or bacteria. aneuploidy proven be unique by DNA fingerprinting analysis....
High-quality bowel preparation is necessary for colonoscopy. A few studies have been conducted to investigate improvement in quality through patient education. However, the effect of education on has not well studied. randomized and prospective study was conducted. All patients received regular instruction during a pre-colonoscopy visit. Those scheduled colonoscopy were randomly assigned view an educational video (video group) day before colonoscopy, or non-video (control) group. Qualities...
Objective Previous studies have shown that leukocyte cell-derived chemotaxin 2 (LECT2), a recently discovered hepatokine, is associated with the inflammatory response and insulin resistance. We examined circulating plasma LECT2 levels in subjects non-alcoholic fatty liver disease (NAFLD) or metabolic syndrome. Methods analyzed from of age- sex-matched 320 adults without NAFLD who completed health check-up at Health Promotion Center Korea University Guro Hospital. Results Individuals showed...
Lewy bodies (LBs) are pathological hallmarks of Parkinson disease (PD) but also occur in Alzheimer (AD) and dementia LBs. Alpha-synuclein, the major component LBs, is observed brain Down syndrome (DS) patients with AD. Dyrk1A, a dual specificity tyrosine-regulated kinase (Dyrk) family member, mammalian ortholog Drosophila minibrain (Mnb) gene, essential for normal postembryonic neurogenesis. The Dyrk1A gene resides human chromosome 21q22.2 region, which associated DS anomalies, including...
To evaluate the inflammasome activation and effect of peroxisome proliferator-activated receptors (PPAR)-δ agonist treatment in nonalcoholic fatty liver disease (NAFLD) models.Male C57BL/6J mice were classified according to control or high fat diet (HFD) with without PPAR-δ (GW) over period 12 wk [control, HFD, HFD + lipopolysaccharide (LPS), LPS GW group]. HepG2 cells exposed palmitic acid (PA) and/or absence presence GW.HFD caused glucose intolerance hepatic steatosis. In fed an LPS,...
Hyun Jung Lee, Sun-Hee Oh, Hui Won Jang, Ji-Hee Kwon, Kyoung Jin Chung Hee Kim, Soo Park, Sung Pil Hong, Jae Cheon, Tae Il and Ho Kim. Gut Liver 2016;10:412-9. https://doi.org/10.5009/gnl15229
Individualizing adjuvant chemotherapy is important in patients with advanced colorectal cancers (CRCs), and the ability to identify molecular subtypes predictive of good prognosis for stage III CRCs after could be highly beneficial. We performed microarray-based gene expression analysis on 101 fresh-frozen primary samples from treated FOLFOX 35 matched non-neoplastic mucosal tissues. CRC were classified into four using nonnegative matrix factorization, comparison, we also grouped proposed...
Nonalcoholic fatty liver disease (NAFLD) is the most common worldwide. Ultrasound, used tool for diagnosing NAFLD, operator-dependent and shows suboptimal performance in patients with mild steatosis. However, few studies have been conducted on whether alternative noninvasive methods are useful hepatic Also, little known about tests grading severity of steatosis or degree intrahepatic inflammation. Therefore, we aimed to evaluate HSI, FLI HU values CT could be discriminate inflammation...
Abstract Despite the improved outcomes in patients with hematological malignancies, infections caused by multidrug-resistant organisms (MDROs) pose a new threat to these patients. We retrospectively reviewed cancer and bacterial bloodstream (BSIs) at tertiary hospital between 2003 2022 assess impact of MDROs on outcomes. Among 328 BSIs, 81 (24.7%) were MDROs. MDRO rates increased from 10.3% (2003–2007) 39.7% (2018–2022) ( P < 0.001). The 30-day mortality rate was 25.0%, which...
The incidence of treatment failure or recurrence Clostridium difficile-associated diarrhea (CDAD) following metronidazole has increased recently. We studied the failure, rate, and risk factors predictive after for CDAD.We retrospectively identified consecutive patients who were admitted treated CDAD at a single tertiary institution in Korea over recent 10-year period (i.e., 1998-2008).Metronidazole was administered as initial to 111 117 (94.9%) with CDAD. Fourteen (12.6%) had no clinical...
Background. Anastomotic leak is a dreadful complication with high mortality rate. The authors aimed to evaluate the efficacy of endoscopic closure anastomotic dehiscence after gastrectomy in patients gastric cancer. Methods. retrospectively reviewed 33 leakage who had underdone treatment among 5249 cancer underwent radical total or subtotal gastrectomy. Methods included clipping without detachable snare, fibrosealant, Histoacryl® stent insertion. Results were categorized as complete, partial...