A5047165960- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Anorectal Disease Treatments and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Diverticular Disease and Complications
- Gut microbiota and health
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Enhanced Recovery After Surgery
- Appendicitis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Intraperitoneal and Appendiceal Malignancies
- Nutrition and Health in Aging
- Stoma care and complications
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Ovarian cancer diagnosis and treatment
- Cancer survivorship and care
- Gastrointestinal Tumor Research and Treatment
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
National University College
2012-2024
New Generation University College
2009-2024
Boramae Medical Center
2022-2024
Seoul National University Bundang Hospital
2007-2024
Seoul Metropolitan Government
2022
Pusan National University
2019-2020
National Cancer Center
2003-2012
Cancer Research Institute of the Slovak Academy of Sciences
2012
<h3>Importance</h3> Ovarian cancer has the highest mortality rate among gynecologic malignant tumors. Data are lacking on survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in women with ovarian who underwent primary or interval cytoreductive surgery. <h3>Objective</h3> To assess clinical HIPEC after maximal surgery stage III IV advanced cancer. <h3>Design, Setting, and Participants</h3> In this single-blind randomized trial performed at 2 institutions South Korea from...
The probiotic gut microbiome and its metabolites are pivotal in regulating host metabolism, inflammation, immunity. Host genetics, colonization at birth, the lifestyle, exposure to diseases drugs determine microbial composition. Dysbiosis disruption of homeostasis beneficial have been reported be involved tumorigenesis progression colorectal cancer (CRC). However, influence bacteria-secreted on CRC growth is yet fully elucidated. In this study, we compared composition patients healthy...
We performed a retrospective review of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) examination to determine the prevalence thyroid FDG-PET incidentaloma in patient group evaluated for metastasis cancer and healthy subjects who underwent voluntary screening. also risk malignancy focal its association with standard uptake values (SUVs) (maximum greater than 0.75 threshold). A total 1330 evaluation (n = 999) screening 331). Twenty-nine (2.2%) showed 21) or diffuse 8)...
Purpose Although combined-modality therapy (CMT) is the preferred treatment for T3 and/or lymph node (LN)-positive rectal cancer, German cancer study published in 2004 demonstrated that 18% of patients deemed suitable preoperative CMT by endorectal ultrasound (ERUS) may be overstaged. Because data also suggest LN-negative after total mesorectal excision not require radiotherapy, it reasonable to consider omitting radiotherapy cT3N0 subset. We therefore determined accuracy pre-CMT ERUS or...
We conducted a population-based retrospective cohort study to investigate the influence of hospital volume, delay surgery, and both together on long-term survival postoperative cancer patients.Using information from Korea Central Cancer Registry 2001 through 2005 National Health Insurance claim database, we determined for 147 682 patients who underwent definitive surgery any six cancers.Regardless site, surgical in low- medium-volume hospitals showed significantly worse [adjusted hazard...
To determine whether an Internet-based tailored education program is effective for disease-free cancer survivors with cancer-related fatigue (CRF).We randomly assigned patients who had completed primary treatment within the past 24 months in any of four Korean hospitals and reported moderate to severe at least 1 week participate a 12-week, Internet-based, individually CRF or receive routine care. We based on guidelines National Comprehensive Cancer Network (NCCN) incorporated transtheoretic...
Recent sequencing studies revealed that a subset of colorectal cancer harbors significantly higher number somatic mutations. These hypermutated tumors show distinct clinicopathologic features. However, the prognostic impact is not clearly established.We analyzed tumor mutation burden (TMB) from targeted next-generation data 40 major genes in 516 patients with cancer. TMB was defined as total nonsynonymous mutations per tumor. Cutoff value for TMB-high chosen by which best discriminated...
RNA editing can increase sequence variation without altering the DNA sequence. By comparing whole-genome and transcriptome data of a rectal cancer, we found novel tumor-associated in ras homologue family member Q (RHOQ) transcripts. The adenosine-to-inosine (A-to-I) results substitution asparagine with serine at residue 136. We observed higher level RHOQ tumor compared normal tissue colorectal cancer (CRC). degree was associated RhoQ protein activity CRC cell lines. N136S amino acid...
A significant proportion of colorectal cancer (CRC) patients suffer from early recurrence and progression after surgical treatment. Although the gut microbiota is considered as a key player in initiation CRC, most prospective studies have been focused on particular pathobionts such Fusobacterium nucleatum. Here, we aimed to identify novel prognostic bacteria for CRC by examining preoperative through 16S ribosomal RNA gene sequencing.We collected stool samples 333 with primary within 2 weeks...
Throughout an individual's lifetime, genomic alterations accumulate in somatic cells
Purpose: Preoperative chemoradiotherapy is widely used to improve local control and sphincter preservation in patients with locally advanced rectal cancer. In the present study, we investigated whether microarray gene expression analysis could predict complete response preoperative Methods: Tumor tissues were obtained from 46 cancer (31 for training 15 validation testing). All underwent involving 50.4 gray radiotherapy, followed by surgical excision 6 weeks later. Response was evaluated...
Abstract Purpose: Metabotropic glutamate receptors (mGluR) play a variety of roles in both neuronal and nonneuronal cells. Recently, we reported that mGluR4 mediates 5-fluorouracil resistance human colon cancer cell line. In this study, evaluated the nonneural expression clarified existence normal epithelium colorectal carcinomas. We also investigated association levels with various clinicopathologic parameters. Experimental Design: was 21 312 malignant tissues from organs using...
In Brief Objective: To evaluate the effect of time interval between chemoradiotherapy (CRT) and surgery on CRT response surgical outcomes. Summary Background Data: Although preoperative is a standard component multimodal treatment for locally advanced rectal cancers, optimal after has yet to be established. This study analyzed outcomes in 397 prospectively enrolled patients with cancer who underwent fractionated involving 50.4 Gy radiotherapy followed by resection 4 8 weeks later. Methods:...
To evaluate the relation of preoperative chemoradiotherapy to number lymph nodes retrieved in curative intent surgery for rectal cancer.Current guidelines recommend evaluation least 12 14 cancer. It is well known that retrieval affected by many factors.This was a retrospective study 615 patients who underwent primary Preoperative involving 50.4 Gy fractionated radiotherapy and concurrent chemotherapy performed with locally advanced cancer (clinically T3 or T4). We explored associations...
Recent advance in sequencing technology has enabled comprehensive profiling of genetic alterations cancer. We have established a targeted platform using next-generation (NGS) for clinical use, which can provide mutation and copy number variation data. NGS was performed with paired-end library enriched exons 183 cancer-related genes. Normal tumor tissue pairs 60 colorectal adenocarcinomas were used to test feasibility. Somatic alteration analyzed. A total 526 somatic non-synonymous sequence...