A5009151086- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Sleep and related disorders
- Helicobacter pylori-related gastroenterology studies
- Bladder and Urothelial Cancer Treatments
- Esophageal Cancer Research and Treatment
- Sleep and Wakefulness Research
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Lung Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
Samsung Medical Center
2021-2025
Inha University
2025
National Cancer Center
2015-2024
Sungkyunkwan University
2022-2024
Severance Hospital
2023
National Institute of Environmental Research
2022
Kyungwoon University
2021
Management Research Institute
2020
Seoul National University
2017-2019
Asan Medical Center
2015-2019
Patients with early gastric cancers that are limited to mucosa or submucosa usually have an advanced loss of mucosal glandular tissue (glandular atrophy) and at high risk for subsequent (metachronous) development new cancer. The long-term effects treatment eradicate Helicobacter pylori on histologic improvement the prevention metachronous cancer remain unclear.
Helicobacter pylori infection and a family history of gastric cancer are the main risk factors for cancer. Whether treatment to eradicate H. can reduce in persons with first-degree relatives is unknown.In this single-center, double-blind, placebo-controlled trial, we screened 3100 patients We randomly assigned 1838 participants receive either eradication therapy (lansoprazole [30 mg], amoxicillin [1000 clarithromycin [500 each taken twice daily 7 days) or placebo. The primary outcome was...
Although gastric cancer screening is common among countries with a high prevalence of cancer, there little data to support the effectiveness this screening. This study was designed determine differences in stage at diagnosis according history and method (upper gastrointestinal series (UGIS) vs endoscopy). The population derived from National Cancer Screening Programme (NCSP), nationwide organised programme Korea. cohort consisted 19 168 patients who had been diagnosed 2007 were invited...
Proton beam radiotherapy (PBT) has recently been applied to treat hepatocellular carcinoma (HCC); however, there is no randomized controlled trial-based evidence on its safety and efficacy. We compared the outcomes of PBT radiofrequency ablation (RFA) in patients with recurrent/residual HCC (rHCC) a phase III non-inferiority trial.Patients rHCC (size <3 cm, number ≤2) were randomly assigned receive or RFA according Child-Pugh score tumor stage. After randomization, if treatment was...
<h3>Importance</h3> Ovarian cancer has the highest mortality rate among gynecologic malignant tumors. Data are lacking on survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in women with ovarian who underwent primary or interval cytoreductive surgery. <h3>Objective</h3> To assess clinical HIPEC after maximal surgery stage III IV advanced cancer. <h3>Design, Setting, and Participants</h3> In this single-blind randomized trial performed at 2 institutions South Korea from...
There is still an unmet need for comparative analyses of available treatment options neuromyelitis optica spectrum disorder (NMOSD).We aimed to compare the efficacies immunosuppressants most commonly prescribed patients with NMOSD using multifaceted endpoints.We conducted a retrospective analysis outcomes in 138 treated azathioprine, mycophenolate mofetil (MMF), or rituximab. The primary outcome measures were annualized relapse rate (ARR), severe rate, time first relapse, and relapse.A...
Cell-free DNA (cfDNA) is known to provide potential biomarkers for predicting clinical outcome, but its value in pancreatic ductal adenocarcinoma (PDAC) has not been fully evaluated. The aim of this study was evaluate the applicability quantitative analysis multiplex KRAS mutations cell-free from patients with PDAC.A total 106 PDAC were enrolled prospective study. concentration and fraction determined through detection plasma samples by use a droplet digital PCR kit (Bio-Rad).KRAS detected...
Objective To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma (RCC). Methods Patients who underwent a nephrectomy during 1992–2015 had primary specimen their kidney tumor were included. The nine immunohistochemically stained on microarrays RCC, semi-quantitative H-score, including intensity score, was used to grade sample. Cox proportional hazards model evaluate markers significant for overall...
To evaluate the associations between intravoxel incoherent motion (IVIM)-derived parameters and histopathological features subtypes of breast cancer.Pre-operative MRI from 275 patients with unilateral cancer was analyzed. The apparent diffusion coefficient (ADC) IVIM [tissue (Dt), perfusion fraction (fp) pseudodiffusion coefficient] were obtained normal tissue using diffusion-weighted imaging b-values 0, 30, 70, 100, 150, 200, 300, 400, 500 800 s mm(-2). We then compared tumours different...
Abstract Background Skin antiseptic agents are used to prevent surgical-site infection (SSI); few trials have reported the superiority of any specific agent in clean-contaminated abdominal surgery. This RCT was designed compare effectiveness chlorhexidine gluconate and povidone–iodine. Methods Consecutive patients who underwent upper gastrointestinal or hepatobiliary–pancreatic open surgery between 2011 2014 were assigned randomly either The primary endpoint occurrence SSI within 30 days...
Predicting lymph node metastasis (LNM) risk is crucial in determining further treatment strategies following endoscopic resection of T1 colorectal cancer (CRC). This study aimed to establish a new prediction model for the LNM CRC patients.The development set included 833 patients with who had undergone (n=154) or surgical (n=679) at National Cancer Center. The validation 722 (n=249) (n=473) Daehang Hospital. A logistic regression was used construct model. To assess performance model,...
In this multicenter, open-label, single-arm, Phase II study with Simon two-stage optimum design (NCT04361370), we investigate the efficacy and safety of triplet maintenance (olaparib, pembrolizumab, bevacizumab) in patients platinum-sensitive recurrent ovarian cancer who are wild-type for BRCA 1/2. A total 44 were enrolled, median follow-up duration was 22.9 months (interquartile range: 17.4-24.7). The primary outcome 6-months progression-free survival (PFS), which 88.6% (95% confidence...
Background and AimsNivolumab is the first immune checkpoint inhibitor for hepatocellular carcinoma (HCC). External beam radiation therapy (EBRT) locally effective may enhance effectiveness of immunotherapy. This study investigated efficacy safety concurrent nivolumab EBRT in HCC with macrovascular invasion.MethodsIn this phase 2 multicenter trial, patients invasion were concurrently treated intravenous (3 mg/kg every weeks) EBRT, followed by maintenance until progression or unacceptable...
Purpose Upon extending Hoffman and Novak's flow model, this paper aims to delineate the blogging motivations with an emphasis of mediation predict behaviors. Three objectives are to: identify determinant dimensions motivations, behaviors flow; investigate hypothesized relationships between control moderating effect individual differences (i.e. blogger blog reader) disperse their Design/methodology/approach Using self‐administered questionnaire, data ( n =432) collected from students at a...
Anemarrhena asphodeloides has been widely used in traditional medicine for thousands of years; it reported to improve learning and memory, reduce inflammation. However, the role A. enhancing immune response remained unclear.This study aimed evaluate effect extract (AA-Ex) on macrophages identify active compounds causing these effects.To determine AA-Ex its compounds, cell proliferation cycle RAW 264.7 cells were analyzed by MTS assay flow cytometry. The gene expression p53, p27, cyclin D2,...
Among the various psychiatric disorders, depression is a common comorbid condition in cancer patients. Due to distinct and diverse nature of cancer, prevalence may be assumed affected by differences primary sites. In this study, we explored rates among ten most prevalent cancers South Korea using national patient sample.This was 1-year cross-sectional study sample provided Korean National Health Insurance 2011. We selected all patients who had received ICD-10 codes 10 major depressive...
Background: Previous studies on the effect of Helicobacter pylori eradication functional dyspepsia (FD) are conflicting. We performed a comprehensive meta-analysis this issue according to region and prevalence H. pylori. Methods: Randomized controlled trials (RCTs) evaluating up December 2018 were searched through PubMed, EMBASE, Cochrane Library. Subgroup analyses by outcome measure, region, performed. All data analyzed with Review Manager 5.3. Results: Eighteen RCTs included in our...
Purpose To investigate the predictive factors for lateral pelvic lymph node (LPLN) metastasis in patients with locally advanced rectal cancer treated preoperative chemoradiotherapy (CRT). Materials and methods Fifty-seven LPLNs larger than 5 mm underwent LPLN dissection (LPLD) after CRT. The MRI findings, including apparent diffusion coefficient value size reduction rate before/after CRT; clinical factors; pathologic results were evaluated to identify associated metastasis. Results was...
Background Interstitial lung abnormalities (ILAs) are associated with the risk of cancer and its mortality. However, impact ILA on treatment-related complications survival in patients who underwent curative surgery is still unknown. Research question This study aimed to evaluate significance presence computed tomography-diagnosed histopathologically matched interstitial postoperative pulmonary (PPCs) long-term surgical treatment for cancer. Study design methods A case–control was designed...