A5087105832- Skin Protection and Aging
- Advanced Glycation End Products research
- Asthma and respiratory diseases
- Phytochemistry and Bioactive Compounds
- Bee Products Chemical Analysis
- Genomics, phytochemicals, and oxidative stress
- Heme Oxygenase-1 and Carbon Monoxide
- Natural product bioactivities and synthesis
- Dermatology and Skin Diseases
- Alcohol Consumption and Health Effects
- Pediatric health and respiratory diseases
- Histone Deacetylase Inhibitors Research
- melanin and skin pigmentation
- Plant-based Medicinal Research
- Marine Sponges and Natural Products
- Curcumin's Biomedical Applications
- Phytochemical Studies and Bioactivities
- RNA Interference and Gene Delivery
- Respiratory and Cough-Related Research
- Fungal Biology and Applications
- Synthesis of Organic Compounds
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Adenosine and Purinergic Signaling
Korea Institute of Oriental Medicine
2015-2024
Korea University of Science and Technology
2018-2024
University of Science and Technology
2017-2019
Wonkwang University
2006-2008
Kangwon National University
2001-2007
Samsung Medical Center
2007
Sungkyunkwan University
2007
Sphingosine 1-phosphate (S1P) can prevent endothelial cell apoptosis. We investigated the molecular mechanisms and signaling pathways by which S1P protects cells from serum deprivation-induced show here that human umbilical vein (HUVECs) undergo apoptosis associated with increased DEVDase activity, caspase-3 activation, cytochromec release, DNA fragmentation after 24 h of deprivation. These apoptotic markers were suppressed addition S1P, NO donorS-nitroso-N-acetylpenicillamine (100 μm), or...
Carbon monoxide (CO), a reaction product of the cytoprotective heme oxygenase (HO)-1, is antiapoptotic in variety models cellular injury, but precise mechanisms remain to be established. In human umbilical vein endothelial cells, exogenous CO activated Nrf2 through phosphorylation protein kinase R-like endoplasmic reticulum (PERK), resulting HO-1 expression. CO-induced activation PERK was followed by eukaryotic translation initiation factor 2alpha and expression activating transcription 4....
Melanoma is the leading cause of death from skin disease, due in large part to its propensity metastasize. We examined effects timosaponin AIII, a compound isolated Anemarrhena asphodeloides Bunge, on melanoma cancer cell migration and molecular mechanisms underlying these using B16-F10 WM-115 cells lines. Overexpression COX-2, metabolite prostaglandin E2 (PGE2), PGE2 receptors (EP2 EP4) promoted vitro. Exposure AIII resulted concentration-dependent inhibition migration, which was associated...
Anemarrhena asphodeloides has been widely used in traditional medicine for thousands of years; it reported to improve learning and memory, reduce inflammation. However, the role A. enhancing immune response remained unclear.This study aimed evaluate effect extract (AA-Ex) on macrophages identify active compounds causing these effects.To determine AA-Ex its compounds, cell proliferation cycle RAW 264.7 cells were analyzed by MTS assay flow cytometry. The gene expression p53, p27, cyclin D2,...
Phycocyanin (Pc) is one of the active pigment constituents Spirulina microalgae. It has been used for its potent antioxidant and anti-inflammatory properties. However, protective effects Pc against ultraviolet-B (UVB)-induced primary skin cells damage are still undefined. In present study, we investigated whether prevented UVB-induced apoptotic cell death in human dermal fibroblasts (HDF) epidermal keratinocytes (HEK). induced transcription heme oxygenase-1 (HO-1). Furthermore, treatments...
The present study evaluated the mechanism of apoptosis caused by post-translational modification, hyperacetylation in triple-negative breast cancer (TNBC) cells. We previously showed that trichostatin A (TSA) induced secretion acetylated apurinic apyrimidinic endonuclease 1/redox factor-1 (Ac-APE1/Ref-1). This is first report showing Ac-APE1/Ref-1 initiates TNBC cells binding to receptor for advanced glycation end products (RAGE). functional significance secreted was studied induction...
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction and responses. Reynoutria japonica, known as Huzhang in traditional Chinese Medicine, can enhance blood circulation to eliminate wind pathogens terminate coughing. Despite pharmacological evidence supporting the efficacy of R. japonica suppressing edema-induced inflammation or connective tissue diseases, its pharmaceutical potential for treating AD-like remains unexplored. This study...
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. AD pathogenesis associated with increased oxidative stress, impairment barrier, and activation immune response. Rosmarinic acid (RA), a caffeic ester, known for its anti-inflammatory antioxidant properties. However, effects RA on Dermatophagoides farinae extract (DfE)-induced AD-like inflammation, as well ability to regulate stress through Nrf2/HO-1 pathway in TNF-α/IFN-γ-treated keratinocytes, remain...
The leaves of Petasites japonicus are used for their anti-allergic properties in traditional Korean, Japanese, and Chinese medicine. This study aimed to identify bioactive compounds isolated from P. leaves. All were assessed ability transcriptional activation, induction phase 2 enzymes heat shock proteins (HSPs), as well protection against the UVB-induced apoptotic cell death. Bioactive evaluated protective effect using human dermal fibroblasts (HDF) epidermal keratinocyte cells (HEKC)...
UVB radiation changes several photoaging pathway in the body, thereby prompting skin injury. Besides, chronic leads to photoaging, sustained immunosuppression, and photocarcinogenesis. We investigated protective effect of Timosaponin AIII (TA-III), a naturally occurring steroidal saponin separated from Anemarrhena asphodeloides, against UVB-induced invasive properties human epidermal keratinocytes (HEKs) dermal fibroblasts (HDF). No cytotoxicity was observed up 50 nM concentration TA-III....
The molecular mechanism underlying the anticancer effects of Anemarrhena asphodeloides (A. asphodeloides) on colon cancer is unknown. This first study evaluating effect A. extract (AA-Ex) in serum-starved colorectal cells. Changes cell proliferation and morphology MC38 HCT116 cells were investigated using MTS assay. Cell cycle apoptosis flow cytometry, regulator expression was determined qRT-PCR. Apoptosis protein levels mitogen-activated kinase (MAPK) phosphorylation assessed western...
Abstract Background Timosaponin A‐III (TA‐III) is known to exist in the medicinal herb of Anemarrhena asphodeloides as one major chemical components. Aims The photoprotective properties TA‐III on UVB‐exposed HaCaT cells were evaluated antiwrinkle effects and skin safety terms clinical trial. Methods level matrix metalloproteinase (MMP)‐1, tissue inhibitor metalloproteinases (TIMPs), pro‐inflammatory cytokines measured following UVB irradiation. To evaluate an agent containing 0.25% for use...