The present study optimized ultrasound-assisted extraction conditions to maximize yields of glycyrrhizic acid from licorice.

Forsythia suspensa (F. suspensa) is a traditional medicine for treatment of inflammation. In this study, we evaluated the therapeutic effects an ethanol extract from F. fruits on atopic dermatitis both in vivo and vitro. We investigated inhibitory development dermatitis-like skin lesions NC/Nga mouse model exposed to Dermatophagoides farinae crude extract. Topical application mice attenuated symptoms, including increased severity score, ear thickness, infiltration inflammatory cells lesions,...

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction and responses. Reynoutria japonica, known as Huzhang in traditional Chinese Medicine, can enhance blood circulation to eliminate wind pathogens terminate coughing. Despite pharmacological evidence supporting the efficacy of R. japonica suppressing edema-induced inflammation or connective tissue diseases, its pharmaceutical potential for treating AD-like remains unexplored. This study...

Atopic dermatitis is caused by various factors, including complex interactions between immune responses and imbalances in T helper cells. In order to resolve the side effects of steroid-based treatment rapidly improve atopy symptoms, development preventive substances for new treatments as food supplements essential. Pulsatilla koreana Nakai (PKN) traditionally used an effective herbal medicine pain relief, anti-inflammation, edema, dried PKN boiled drunk a tea prevent them; however, its...

Alpinia officinarum (AO) has been traditionally used in Asia as an herbal medicine to treat inflammatory and internal diseases. However, the therapeutic effect of AO on atopic dermatitis (AD) is unclear. Therefore, we examined whether water extract (AOWex) affects AD vivo vitro. Oral administration AOWex NC/Nga mice with Dermatophagoies farina (DfE)-induced AD-like symptoms significantly reduced severity clinical dermatitis, epidermal thickness, mast cell infiltration into skin ear tissue....

S. patholobus suberectus Dunn, a traditional Chinese herbal medicine, has various pharmacological activities, such as anti-inflammatory properties. However, to the best of our knowledge, its therapeutic effect on atopic dermatitis (AD) not been investigated. In this study, we explored Dunn water extract (SSWex) AD in vivo and vitro . Dermatophagoides farina (DfE)–treated NC/Nga mice, oral administration SSWex alleviated AD-like symptoms, ear thickness, score, epidermal immune cell...

Abstract Atopic dermatitis (AD) is an allergic, inflammatory skin disease caused by immune dysregulation. In this study, we investigated anti-atopic and anti-inflammatory activities of Sanguisorba hakusanensis ethanol extract (SHE) both in vivo using NC/Nga mice vitro human HaCaT keratinocytes. Oral administration SHE suppressed several atopic symptoms associated with house dust mites (induced Dermatophagoides farinae extract) decreased serum levels mediators such as immunoglobulin E,...

Veronica persica is a flowering plant belonging to the family Scrophulariaceae. Here, we aimed evaluate pharmacological activity of ethanol extract (EEVP) in an airway inflammation model. We examined responsiveness aerosolized methacholine, serum immunoglobulin (Ig)E levels, and total cell numbers lung bronchoalveolar lavage fluid (BALF). Histological analysis tissue was performed using hematoxylin-eosin, Masson trichrome, or periodic acid-Schiff staining. Fluorescence-activated sorting BALF...

Incorporation of an electron-withdrawing −SO2CF3 substituent to cyclometalating C^N-phenylpyridine (ppy) ligand resulted in expected blue-shifted phosphorescence the corresponding homoleptic Ir(ppySCF3)3 complex, showing emission λem = 464 nm at 300 K. One its heteroleptic derivatives, modified by a pyrazolyl borate LX ligand, Ir(ppySCF3)2(bor), exhibited further 460 Cyclic voltammograms (CVs) and density-functional theory (DFT) calculations supported efficacy capability SO2CF3 lowering HOMO...

Jinmu-tang (JMT) is a traditional herbal medicine consisting of five medicines: Poria cocos Wolf, Paeonia lactiflora Pallas, Zingiber officinale Roscoe, Atractylodes japonica Koidzumi, and Aconitum carmichaeli Debeaux. In this study, the JMT components were profiled using UHPLC-Q-Orbitrap-MS, 23 compounds identified characterized. addition, UPLC-TQ-MS/MS analysis was performed in positive negative ion modes an electrospray ionization source for simultaneous quantification compounds. The...

In this study, a method to both qualitatively and quantitively analyze the components of Oryeong-san (ORS), which is composed five herbal medicines (Alisma orientale Juzepzuk, Polyporus umbellatus Fries, Atractylodes japonica Koidzumi, Poria cocos Wolf, Cinnamomum cassia Presl) prescribed in traditional Oriental medicine practices, was established for first time. First, ORS were profiled using ultra-high-performance liquid chromatography/quadrupole Orbitrap mass spectrometry, 19 compounds...

Atopic dermatitis (AD) leads to skin barrier abnormalities and immune dysfunction. As the topical steroids commonly used treat AD have side effects from long-term use, research into safer treatments for is greatly needed. The medicinal herb Gardenia jasminoides improves symptoms via activation T helper 2-mediated response regulation. Crocin, a bioactive component within extract, dispensible its restorative effects. such, this work explored of extract without crocin (GjexCr) on in DfE-induced...

Do In Seung Gi-Tang (DISGT) is an herbal mixture of traditional Korean medicine that composed Rheum undulatum Linne, Prunus Persica (L.) Batsch, Conyza canadensis L., Cinnamomum Cassia Presl, and Glycytthiza uralensis Fischer (8: 6: 4: 4 ratio). We investigated the effect DISGT on vascular inflammation lipid accumulation in apolipoprotein E-deficient (ApoE(-/-)) mice.ApoE(-/-) mice were fed a high-fat diet (HFD) treated with (300 mg/kg/day) or statin (10 for 16 weeks. Serum levels analyzed....

Owing to the side effects of current drugs for treating atopic dermatitis (AD), a chronic disease in skin, traditional herbal medicine is receiving much attention as an alternative treatment. Asarum sieboldii has traditionally been used treat colds, fevers, headaches, coughs, neuralgia, bronchitis, asthma, and allergies. In this study, 6 compounds (echinacoside, vanillic acid, kakuol, methyl eugenol, sesamin, asarinin) A. were analyzed simultaneously using high-performance liquid...

Objectives : Iridoid glycoside, swertiamarin is a well known bioactive component found in Swertia japonica Makino (SJ). In this study, we tried to optimize suitable method which would extract effectively. Methods Extraction of SJ was carried out by various conditions time (5 - 60 min), temperature (<TEX>$30-70^{\circ}C$</TEX>), solvent (from non-polar polar), and ratio solvnet / sample (10 1 40 1) using ultrasonic extractor. Swertiamarin extracts quantified high performance liquid...

In this study, we analyzed the components of Banhasasim-tang (BHSST), a traditional prescription used to treat gastrointestinal disorders. Qualitative analysis was performed using ultra-high-performance liquid chromatography/quadrupole Orbitrap mass spectrometry (UHPLC-Q-Orbitrap-MS), and total 42 compounds were accurately unambiguously identified by comparison with corresponding reference standards (MS) results. A simultaneous quantitative method for 22 established UHPLC coupled...

Sayeok-tang (SYT) is a traditional herbal formula comprising three medicinal herbs: Glycyrrhiza uralensis, Zingiber officinale, and Aconitum carmichaeli. Several studies have employed liquid chromatography-mass spectrometry (LC-MS) to qualitatively analyze the components metabolites of SYT in vitro vivo; however, on quantitative analysis SYT, which important for quality control, are absent or limited only few components. In this study, ultrahigh-performance chromatography coupled with...

The Ponciri fructus immaturus (Poncirus trifoliata Rafinesque) has been used in oriental medicine for uterinecontraction, stomachache, abdominal distension and cardiovascular diseases. Two main compounds, poncirin naringinwere successfully analyzed by high performance liquid chromatography (HPLC) carried out method validation accordingto ICH guideline. A successful resolution retention times were obtained with a C18 reversed phase column, at an 1 ㎖min?1 flow rate, gradient elution of mixture...