A5054220148- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Air Quality and Health Impacts
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- IL-33, ST2, and ILC Pathways
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Air Quality Monitoring and Forecasting
- Liver Disease Diagnosis and Treatment
- Tea Polyphenols and Effects
- Hormonal and reproductive studies
- Antimicrobial Peptides and Activities
- Natural product bioactivities and synthesis
- Antiplatelet Therapy and Cardiovascular Diseases
- Contact Dermatitis and Allergies
- Bioactive Compounds in Plants
Daejeon University
2016-2024
Korea Research Institute of Bioscience and Biotechnology
2022
Kyiv Institute of Traditional Medicine
2020
Sangji University
2019
Dunsan Korean Medicine Hospital
2017
Korea Institute of Oriental Medicine
2011-2014
Asan Medical Center
2012
Konkuk University
1994
Duksung Women's University
1994
Chronic obstructive pulmonary disease (COPD) is caused by exposure to toxic particles, such as coal fly ash (CFA), diesel-exhaust particle (DEP), and cigarette smoke (CS), leading chronic bronchitis, mucus production, a subsequent lung dysfunction. This study, using mouse model of COPD, aimed evaluate the effect herbal combinational medication Glycyrrhiza glabra (GG), Agastache rugosa (AR) containing glycyrrhizic acid (GA), tilianin (TN) active ingredients. GA, major component GG, possesses...
Insects represent the largest and most diverse group of organisms on earth are potential food drug resources. Recently, we have demonstrated that a Forsythia viridissima extract prevented free fatty acid-induced lipid accumulation in an vitro cellular nonalcoholic liver disease (NAFLD) model. In this study, aimed to evaluate hepatoprotective effects extracts insects Protaetia brevitarsis seulensis Kolbe, 1886 (PB), Oxya chinensis sinuosa Mishchenko, 1951 (OC), Gryllus bimaculatus De Geer,...
Lemon verbena (Lippia citriodora) has been used as a food spice, cosmetic, and in traditional medicine formulations to treat asthma diabetes South America Southern Europe. Hibiscus flower (Hibiscus sabdariffa L.) is Chinese the form of tea hypertension inflammation. In present study, we examined synergistic effects formula Metabolaid® (MetA), combination lemon hibiscus-flower extracts, on obesity its complications high-fat-diet (HFD)-induced obese mice. The results showed that MetA decreased...
We studied the activities of Siraitia grosvenorii extracts (SGE) on airway inflammation in a mouse model chronic obstructive pulmonary disease (COPD) stimulated by cigarette smoke extract (CSE) and lipopolysaccharide (LPS), as well LPS-treated human bronchial epithelial cell line (BEAS-2B). SGE improved viability LPS-incubated BEAS-2B cells inhibited expression production inflammatory cytokines. also attenuated mitogen-activated protein kinase (MAPK)-nuclear factor-kappa B (NF-κB) signaling...
The antiobesity effects of a P. aviculare ethanol extract (PAE) in high-fat diet- (HFD-) induced obese mice were investigated. fed an HFD or supplemented with PAE (400 mg/kg/day) for 6.5 weeks. increased body weights, adipose tissue weight, and adipocyte area as well serum total triglyceride, leptin, malondialdehyde concentrations decreased PAE-treated HFD-induced relative to the same measurements untreated mice. Furthermore, significantly suppressed elevated mRNA expression levels sterol...
Ethnopharmacological Relevance. Morus alba L. leaves (MAE) have been used in fork medicine for the treatment of beriberi, edema, diabetes, hypertension, and atherosclerosis. However, underlying mechanism MAE on cardiovascular protection remains to be elucidated. Therefore, we investigated whether affect platelet aggregation thrombosis. Materials Methods. The anti-platelet activity was studied using rat platelets. extent assayed collagen-induced aggregation. ATP serotonin release carried out....
Abstract Coal fly dust (CFD)-induced asthma model is used as an ambient particulate matter of serious pulmonary damage. We aimed to evaluate the effects a combination ginseng and Salvia plebeia R. Br extract (KGC-03-PS; KG3P) its individual components (hispidulin, nepetin rosmarinic acid) in CFD-induced mouse airway inflammation (asthma). also evaluated signal transduction by KG3P alveolar macrophage cell line, MH-S cells. In vitro, inhibited nitric oxide production expression...
Cicadae Periostracum (CP), derived from the slough of Cryptotympana pustulata, has been used as traditional medicine in Korea and China because its diaphoretic, antipyretic, anti-inflammatory, antioxidant, antianaphylactic activities. The major bioactive compounds include oleic acid (OA), palmitic acid, linoleic acid. However, precise therapeutic mechanisms underlying action asthma remain unclear. objective this study was to determine antiasthmatic effects CP an ovalbumin (OVA)-induced...
Atopic dermatitis (AD) is chronic allergic contact with immune dysregulation. Veronica persica has pharmacological activity that prevents asthmatic inflammation by ameliorating inflammatory cell activation. However, the potential effects of ethanol extract V. (EEVP) on AD remain elusive. This study evaluated and underlying molecular pathway EEVP in two models: dinitrochlorobenzene (DNCB)-induced mice interferon (IFN)-γ/tumor necrosis factor (TNF)-α-stimulated human HaCaT keratinocytes....
Atopic dermatitis is a persistent inflammatory skin disorder. Siraitia grosvenorii fruits (monk fruit or nahangwa in Korean, NHG) are used as natural sweetener and traditional medicine for the treatment of asthma bronchitis. We evaluated activity S. residual extract (NHGR) on allergic inflammation atopic Dermatophagoides farinae mite antigen (DfE)-treated NC/Nga murine model vitro. Oral administration NHGR significantly reduced epidermal hyperplasia cell infiltration lesions DfE-induced...
Benign prostatic hyperplasia (BPH) is the most common symptomatic abnormality of human prostate characterized by uncontrolled proliferation gland. In this study, we investigated effect bamboo, Phyllostachys pubescens, leaves extract (PPE) on 5α-reductase type 2 (SRD5A2) gene promoter activity in cell lines and protective PPE a testosterone-induced BPH rat model. repressed SRD5A2 its mRNA expression. The rats treated with for 4 weeks showed significantly attenuated weight compared to vehicle...
Exposure to particulate matter (PM) causes considerable breathing-related health risks. Siraitia grosvenorii fruit is a traditional remedial plant used in Korea and China treat respiratory diseases. Our recently published study showed that S. extract (SGE) ameliorated airway inflammation lipopolysaccharide- cigarette-smoke-induced chronic obstructive pulmonary disease mice. Thus, we aimed assess the inhibitory effects of SGE on mice exposed fine dust mixture PM10 (PM diameter < 10 mm)...
Hyacinth bean, Dolichos lablab or Lablab purpureus, has been used for centuries in India and China as an edible pod animal forage, well to treat diarrhea other gastrointestinal disease traditional Korean medicine. Recently, we have demonstrated that D. extract (DLL-Ex) prevented free fatty acid-induced lipid accumulation vitro cellular nonalcoholic liver (NAFLD) model. In this study, we, thus, aimed at clarifying the hepatoprotective effects of DLL-Ex a high-fat diet-induced vivo NAFLD...
Particulate matter (PM) exposure may cause adverse health effects such as respiratory disorders. We evaluated the protective of various Opuntia ficus-indica (OFI) extracts on airway inflammation associated with to PM10D an aerodynamic diameter <10 μm (PM10) and diesel exhaust particles (DEP). BALB/c mice were exposed via intranasal tracheal injection three times over a period 12 days OFI (water, 30% ethanolic, or 50% ethanolic extracts) administered orally for days. All suppressed neutrophil...
Veronica persica is a flowering plant belonging to the family Scrophulariaceae. Here, we aimed evaluate pharmacological activity of ethanol extract (EEVP) in an airway inflammation model. We examined responsiveness aerosolized methacholine, serum immunoglobulin (Ig)E levels, and total cell numbers lung bronchoalveolar lavage fluid (BALF). Histological analysis tissue was performed using hematoxylin-eosin, Masson trichrome, or periodic acid-Schiff staining. Fluorescence-activated sorting BALF...
Ulmus macrocarpa Hance (Ulmaceae) has been used as a traditional oriental medicine for the treatment of edema, mastitis, gastric cancer and inflammation. The aim this study was to investigate effects extract (UME) on thrombus formation in vivo, platelet activation ex vivo fibrinolytic activity vitro. To identify antithrombotic UME we an arterial thrombosis model. delayed occlusion time by 13.4 13.9 min at doses 300 600 mg/kg, respectively. significantly inhibited aggregation induced collagen...
The consequences of increased industrialization the risk asthma and breathing difficulties due to particulate matter in air. We aim investigate therapeutic properties Hypericum ascyron L. extract (HAE) airway inflammation unravel its mechanism action. conducted nitric oxide cell viability assay, real‐time PCR western blot analyses along with vitro studies. vivo studies include a model coal fly ash diesel exhaust particle (CFD)‐induced mice. HAE reduced (CFA)‐induced secretion without...
The roots of Korean red ginseng (Panax C.A.Mey.; KGC) have been used as an herbal supplement to enhance vital energy and immune capacity. Salvia plebeia R.Br. has treat inflammatory diseases. aim this study was examine the anti-asthmatic effects a mixture (KGC3P), its component nepetin, their modes action in alleviating ovalbumin (OVA)-induced asthma mice. BALB/c mice were sensitized with OVA then subjected intratracheal, intraperitoneal, aerosol challenges. KGC3P nepetin administered orally...