A5005976184- Retinoids in leukemia and cellular processes
- Click Chemistry and Applications
- Ginseng Biological Effects and Applications
- Cell death mechanisms and regulation
- Nanocomposite Films for Food Packaging
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Herpesvirus Infections and Treatments
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Photochromic and Fluorescence Chemistry
- Phytochemicals and Antioxidant Activities
- Nanoparticles: synthesis and applications
- Phytochemical compounds biological activities
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- S100 Proteins and Annexins
- Virus-based gene therapy research
- Poxvirus research and outbreaks
- Chemokine receptors and signaling
- Peroxisome Proliferator-Activated Receptors
- Meat and Animal Product Quality
- Pluripotent Stem Cells Research
- Immune Cell Function and Interaction
Konkuk University
2015-2025
Konkuk University Medical Center
2014-2024
Cell Biotech (South Korea)
2019
University of Pennsylvania
2007-2015
Purdue University West Lafayette
2005-2009
Chosun University
2004-2008
University of Alabama at Birmingham
1998-2003
The present study was to prepare chitosan nanoparticles (CNPs) from (CS) evaluate their in vitro antimicrobial activities against phytopathogens of tomato. We prepared and characterized CNPs for particle size, polydispersity index, structures. antifungal properties CS phytopathogenic fungi namely Colletotrichum gelosporidies, Phytophthora capsici, Sclerotinia sclerotiorum, Fusarium oxysporum, Gibberella fujikuori were investigated. showed the maximum growth inhibitory effects on mycelial F....
In the CNS, astrocytes are a major inducible source of interleukin-6 (IL-6). Although IL-6 has beneficial effects in CNS because its neurotrophic properties, overexpression is generally detrimental, adding to pathophysiology associated with disorders. Many factors have been shown induce expression by astrocytes, particularly cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta). However, role own regulation not determined. this study, we examined influence alone...
ABSTRACT A finding commonly observed in human immunodeficiency virus type 1 (HIV-1)-infected patients is invasion of the brain by activated T cells and infected macrophages, eventually leading to development neurological disorders HIV-1-associated dementia. The recruitment macrophages into likely result chemokine expression. Indeed, earlier studies revealed that levels different chemokines were increased cerebrospinal fluid HIV-1-infected whereas possible triggers cellular sources for...
ABSTRACT Previous work has determined that there are nucleosomes on the herpes simplex virus (HSV) genome during a lytic infection but they not arranged in an equally spaced array like cellular DNA. However, DNA, promoter regions of several viral genes have been shown to be associated with containing modified histone proteins generally found actively transcribed genes. Furthermore, it association histones HSV can detected at earliest times postinfection (1 h postinfection) and increases up 3...
Abstract Background Insects and animals can recognize surrounding environments by detecting thousands of chemical odorants. Olfaction is a complicated process that begins in the olfactory epithelium with specific binding volatile odorant molecules to dedicated receptors (ORs). OR proteins are encoded largest gene superfamily mammalian genome. Results We report here whole genome analysis receptor genes S. scrofa using conserved motifs known protein sequences from diverse species. identified...
Abstract Chemokines constitute a superfamily of proteins that function as chemoattractants and activators leukocytes. Astrocytes, the major glial cell type in CNS, are source chemokines within diseased brain. Specifically, we have shown primary human astrocytes astroglioma lines produce CXC IFN-γ-inducible protein-10 IL-8 CC monocyte chemoattractant protein-1 RANTES response to stimuli such TNF-α, IL-1β, IFN-γ. In this study, investigated chemokine receptor expression on cells. Enhancement 4...
Adhesion molecules such as VCAM-1 and ICAM-1 are increased in the central nervous system (CNS) during inflammatory responses contribute to extravasation of leukocytes across blood-brain barrier (BBB) into CNS parenchyma. Astrocytes structural integrity BBB can be induced express response cytokines TNF-alpha, IL-1beta, IFN-gamma. In this study, we investigated influence IL-6 on astroglial adhesion molecule expression. IL-6, soluble form IL-6R (sIL-6R), or both plus sIL-6R, had no effect gene...
Cervical cancer is a life-threatening disease and the fourth most common among women worldwide. Apple pomace multifunctional phenolic compound possessing effective biological activity against cervical cells. This study aimed to investigate anticancer effects of quercetin-3-glucoside (Q3G) extracted from apple in HeLa cell lines analyze its molecular mechanisms. High-performance liquid chromatography revealed that Q3G, coumaric acid, phloridzin, quercetin, phloretin are major polyphenolic...
Cinnamon is a natural spice with wide range of pharmacological functions, including anti-microbial, antioxidant, and anti-tumor activities. The aim this study to investigate the effects cinnamaldehyde-rich cinnamon extract (CRCE) on colorectal cancer cell lines HCT 116 HT-29. gas chromatography mass spectrometry analysis lipophilic revealed dominance trans-cinnamaldehyde. Cells treated CRCE (10-60 µg/mL) showed significantly decreased viability in time- dose-dependent manner. We also...
Plant growth-promoting rhizobacteria (PGPR) are naturally occurring soil biota which benefit plants by improving plant productivity and immunity. The aim of the present work was to evaluate effect inoculation PGPR strain, Bacillus subtilis CBR05 on quality tomato fruits produced under greenhouse conditions. Results were compared with mock-inoculated control market sample. We found a significant increase in total phenol flavonoid contents strain B. inoculated those Moreover, stimulated...
Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The 'classical' of APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins. Accordingly, AP1–3 are for both vesicle formation sorting. All consist four subunits that indispensable their functions. In fact, based on studies using cells, model organism knockdown/knock-out, human variants, each subunit plays roles contributes the specificity AP. These also revealed sorting trafficking...
Farnesyl protein transferase (FPT) catalyzes the post-translational farnesylation of cysteine residue located in carboxyl-terminal tetrapeptide Ras oncoprotein. Prenylation this is essential for membrane association and cell transforming activities Ras. Inhibitors FPT have been demonstrated to inhibit Ras-dependent transformation thus represent a potential therapeutic strategy treatment human cancers (1). In present study, inhibitory principles prenyltransferases were isolated identified...