A5033889770- Food Quality and Safety Studies
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Ecology and Conservation Studies
- Agriculture, Soil, Plant Science
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Eosinophilic Esophagitis
- Pharmacological Effects of Natural Compounds
- Plant chemical constituents analysis
- Flavonoids in Medical Research
- Drug-Induced Hepatotoxicity and Protection
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Traditional Chinese Medicine Analysis
- Inflammatory mediators and NSAID effects
- Bioactive Natural Diterpenoids Research
- Phytochemical Studies and Bioactivities
- Genomics, phytochemicals, and oxidative stress
- Healthcare and Venom Research
- Food composition and properties
- Asthma and respiratory diseases
- Ziziphus Jujuba Studies and Applications
- Exercise and Physiological Responses
- Wheat and Barley Genetics and Pathology
Seoul National University
2024
Jeonbuk National University
2013-2023
Chonbuk National University Hospital
2020
National Institute of Agricultural Science and Technology
2014
Korea Institute of Oriental Medicine
2008-2009
Globally, gastric ulcer is a vital health hazard for human. Rabdosia inflexa (RI) has been used in traditional medicine inflammatory diseases. The present study aimed to investigate the protective effect and related molecular mechanism of RI using lipopolysaccharide (LPS)-induced inflammation RAW 246.7 cells HCl/EtOH-induced mice. We applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde...
Angelicae Decursivae Radix ('Jeonho' in Korean) is prescribed as the root of Angelica decursiva (=Peucedanum decursivum) and Peucedanum praeruptorum Korean pharmacopoeia. However, Anthricus sylvestris has been usually distributed on market because it identical to plant name 'Jeonho'. Furthermore, due morphological similarity aerial parts herbal medicines, correct identification these roots difficult. Therefore, develop a reliable method for discriminating among A. (=P. decursivum), P....
Sodium arsenite (NaAsO2) has been recognized as a worldwide health concern. Hydrangea macrophylla (HM) is used traditional Chinese medicine possessing antioxidant activities. The study was performed to investigate the therapeutic role and underlying molecular mechanism of HM on NaAsO2-induced toxicity in human liver cancer (HepG2) cells mice. hepatoprotective HepG2 assessed by using 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), lactate...
Atopic dermatitis (AD) is chronic allergic contact with immune dysregulation. Veronica persica has pharmacological activity that prevents asthmatic inflammation by ameliorating inflammatory cell activation. However, the potential effects of ethanol extract V. (EEVP) on AD remain elusive. This study evaluated and underlying molecular pathway EEVP in two models: dinitrochlorobenzene (DNCB)-induced mice interferon (IFN)-γ/tumor necrosis factor (TNF)-α-stimulated human HaCaT keratinocytes....
Glehnia littoralis (Umbelliferae) is a traditional medicine used in Korea, China, and Japan to treat the immune-related diseases. However, its anti-inflammatory activities mechanisms remain be defined. We investigated effects of 70% ethanolic extract from G. (GLE) on skin inflammation mice. Production proinflammatory cytokines (IL-1β TNF-α), activation myeloperoxidase (MPO), histological indicators were examined acute chronic using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse...
This study was performed to investigate the effects of berberine (BB) in a rat model gastroesophageal reflux disease (GERD), induced by pylorus and forestomach ligation. We evaluated cytotoxicity proinflammatory biomarkers (nitric oxide, interleukin (IL)-1β prostaglandin E2) RAW 264.7 cells vitro anti-inflammatory vivo. A total 54 Sprague Dawley rats were divided into six groups: intact control rats; esophagitis (RE) RE treated with 20 mg/kg omeprazole BB at doses 20, 40 60 mg/kg,...
Rhei Rhizoma has been widely used as a traditional herbal medicine to treat various inflammatory diseases. The present study was conducted evaluate its anti-inflammatory activity against experimental reflux-induced esophagitis (RE) in SD rats.Rhei administered at 125 or 250 mg/kg body weight per day for 7 days prior the induction of reflux esophagitis, and effect compared with RE control normal administration markedly ameliorated mucosal damage on histological evaluation. elevated reactive...
Anethum graveolens L. (dill seeds) are important medicinal and functional foods in Europe central south Asia, often used as a seasoning daily diets. seeds (AGS) to treat indigestion have shown physiological activities such those against hypoglycemia gastroesophageal disease. This study explored the protective effects of AGS extract on mucosal damages inflammation reflux esophagitis rats. inhibited cellular including NO production expression inflammatory proteins (iNOS COX2 etc.), cytokines...
Abstract Atopic dermatitis (AD) is an allergic, inflammatory skin disease caused by immune dysregulation. In this study, we investigated anti-atopic and anti-inflammatory activities of Sanguisorba hakusanensis ethanol extract (SHE) both in vivo using NC/Nga mice vitro human HaCaT keratinocytes. Oral administration SHE suppressed several atopic symptoms associated with house dust mites (induced Dermatophagoides farinae extract) decreased serum levels mediators such as immunoglobulin E,...
Veronica persica is a flowering plant belonging to the family Scrophulariaceae. Here, we aimed evaluate pharmacological activity of ethanol extract (EEVP) in an airway inflammation model. We examined responsiveness aerosolized methacholine, serum immunoglobulin (Ig)E levels, and total cell numbers lung bronchoalveolar lavage fluid (BALF). Histological analysis tissue was performed using hematoxylin-eosin, Masson trichrome, or periodic acid-Schiff staining. Fluorescence-activated sorting BALF...
Reflux esophagitis (RE) is a gastrointestinal disease caused by the reflux of gastric acid and stomach contents, it leads to esophageal damage. Therefore, necessary study improvement damage on RE-induced model. The present was accomplished demonstrate protective effects dichloromethane fraction Geranium koreanum (DGK) plant in an acute RE rat First, we examined potential anti-inflammatory various fractions measured cell cytotoxicity, morphological changes nitric oxide (NO) production...
The effect on the antioxidant activity and Nitric Oxide production inhibitory of Taraxacum has not been known. Therefore, phenolics flavonoid contents were investigated from ethanol extracts five differ-ent species. results showed that, among Taraxacum, T. hallaisanensis contains highest total phe-nolic contents. When was measured by DPPH, ABTS reducing power activity, free radical scavenging also However, mea-surement CCK-8 assay in Raw264.7 cells indicated that species have no cell...
Geranium koreanum (GK) is an indigenous Chinese herbal medicine widely used for the treatment of various inflammation and liver disorders. However, exact mechanism action GK remains unknown. This study aimed to investigate protective effect related molecular on NaAsO 2 -induced cytotoxicity in HepG2 cells damage mice. The cytoprotective role was assessed using MTT assay. Oxidative stress lactate dehydrogenase levels were measured with ROS LDH Histopathology serum enzymes estimated. evaluated...